STRINGSTRING
MAP3K20 MAP3K20 TRAF2 TRAF2 TIFA TIFA TICAM2 TICAM2 BIRC2 BIRC2 TIRAP TIRAP TLR5 TLR5 NFKBIB NFKBIB TICAM1 TICAM1 TLR10 TLR10 TBK1 TBK1 RIPK3 RIPK3 TNFRSF1A TNFRSF1A LOC100986336 LOC100986336 TLR1 TLR1 CARD14 CARD14 IKBKG IKBKG ALPK1 ALPK1 ENSPPAP00000004994 ENSPPAP00000004994 TNIP1 TNIP1 TLR2 TLR2 PELI3 PELI3 REL REL RIPK1 RIPK1 TAB1 TAB1 MAP3K7 MAP3K7 IRAK4 IRAK4 CYLD CYLD TLR7 TLR7 RNF31 RNF31 TRAF3 TRAF3 LY96 LY96 NOD1 NOD1 PRKCQ PRKCQ NFKBIE NFKBIE BIRC3 BIRC3 TRPV4 TRPV4 IRF7 IRF7 TAB2 TAB2 TAB3 TAB3 NFKB2 NFKB2 TRAF5 TRAF5 RELB RELB TLR4 TLR4 TLR3 TLR3 UNC93B1 UNC93B1 NFKB1 NFKB1 RELA RELA PRKCE PRKCE RBCK1 RBCK1 PRKCH PRKCH PRKCD PRKCD IKBKB IKBKB TNFAIP3 TNFAIP3 PRKCB PRKCB CARD11 CARD11 CARD10 CARD10 TNIP2 TNIP2 TRADD TRADD IRF3 IRF3 IRAK3 IRAK3 MAP3K8 MAP3K8 SHARPIN SHARPIN MALT1 MALT1 MYD88 MYD88 CHUK CHUK ZBP1 ZBP1 BCL3 BCL3 CARD9 CARD9 ZNF567 ZNF567 IRAK2 IRAK2 IKBKE IKBKE BCL10 BCL10 TLR8 TLR8 TANK TANK IRAK1 IRAK1 PELI2 PELI2 ENSPPAP00000035541 ENSPPAP00000035541 MAP3K14 MAP3K14 TRAF1 TRAF1 NFKBIA NFKBIA MLKL MLKL TRAF6 TRAF6 NOD2 NOD2 RIPK2 RIPK2 PELI1 PELI1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (803 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
TIFAUncharacterized protein. (89 aa)
TICAM2TIR domain-containing adaptor molecule 2. (235 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
TIRAPTIR domain-containing protein. (226 aa)
TLR5Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
NFKBIBANK_REP_REGION domain-containing protein. (270 aa)
TICAM1RHIM domain-containing protein. (541 aa)
TLR10TIR domain-containing protein; Belongs to the Toll-like receptor family. (811 aa)
TBK1TANK binding kinase 1. (729 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
LOC100986336TIR domain-containing protein. (1033 aa)
TLR1Toll-like receptor. (786 aa)
CARD14Caspase recruitment domain family member 14. (1001 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
ALPK1Alpha kinase 1. (1246 aa)
ENSPPAP00000004994TNF receptor-associated factor. (475 aa)
TNIP1TNFAIP3 interacting protein 1. (645 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
RELREL proto-oncogene, NF-kB subunit. (619 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (805 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
RNF31Uncharacterized protein. (1072 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
LY96MD2 protein. (160 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (758 aa)
NFKBIENFKB inhibitor epsilon. (486 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
IRF7Interferon regulatory factor 7. (516 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
RELBRELB proto-oncogene, NF-kB subunit. (537 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (561 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
TNFAIP3TNF alpha induced protein 3. (784 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
CARD10Caspase recruitment domain family member 10. (934 aa)
TNIP2CCHC NOA-type domain-containing protein. (322 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
IRF3Interferon regulatory factor 3. (452 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
SHARPINSHANK associated RH domain interactor. (387 aa)
MALT1MALT1 paracaspase. (786 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (719 aa)
ZBP1Z-DNA binding protein 1. (429 aa)
BCL3BCL3 transcription coactivator. (383 aa)
CARD9Caspase recruitment domain family member 9. (536 aa)
ZNF567Zinc finger protein 567. (631 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (625 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
BCL10CARD domain-containing protein. (316 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1041 aa)
TANKTRAF family member associated NFKB activator. (425 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
PELI2Pellino E3 ubiquitin protein ligase family member 2. (394 aa)
ENSPPAP00000035541CCHC NOA-type domain-containing protein. (372 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
TRAF1TNF receptor-associated factor. (416 aa)
NFKBIAANK_REP_REGION domain-containing protein. (456 aa)
MLKLMixed lineage kinase domain like pseudokinase. (471 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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