STRINGSTRING
TRAF2 TRAF2 TICAM2 TICAM2 BIRC2 BIRC2 TIRAP TIRAP TLR5 TLR5 NFKBIB NFKBIB TICAM1 TICAM1 TLR10 TLR10 TBK1 TBK1 TNFRSF1A TNFRSF1A LOC100986336 LOC100986336 TLR1 TLR1 IKBKG IKBKG TNIP1 TNIP1 TLR2 TLR2 REL REL RIPK1 RIPK1 TAB1 TAB1 MAP3K7 MAP3K7 IRAK4 IRAK4 CYLD CYLD TLR7 TLR7 RNF31 RNF31 TRAF3 TRAF3 LY96 LY96 NOD1 NOD1 NFKBIE NFKBIE BIRC3 BIRC3 IRF7 IRF7 TAB2 TAB2 TAB3 TAB3 NFKB2 NFKB2 TRAF5 TRAF5 RELB RELB TLR4 TLR4 TLR3 TLR3 UNC93B1 UNC93B1 NFKB1 NFKB1 RELA RELA RBCK1 RBCK1 IKBKB IKBKB TNFAIP3 TNFAIP3 TNIP2 TNIP2 TRADD TRADD IRF3 IRF3 IRAK3 IRAK3 MAP3K8 MAP3K8 SHARPIN SHARPIN MYD88 MYD88 CHUK CHUK ZBP1 ZBP1 BCL3 BCL3 IRAK2 IRAK2 IKBKE IKBKE TLR8 TLR8 TANK TANK IRAK1 IRAK1 ENSPPAP00000035541 ENSPPAP00000035541 MAP3K14 MAP3K14 TRAF1 TRAF1 NFKBIA NFKBIA TRAF6 TRAF6 NOD2 NOD2 RIPK2 RIPK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
TICAM2TIR domain-containing adaptor molecule 2. (235 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
TIRAPTIR domain-containing protein. (226 aa)
TLR5Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
NFKBIBANK_REP_REGION domain-containing protein. (270 aa)
TICAM1RHIM domain-containing protein. (541 aa)
TLR10TIR domain-containing protein; Belongs to the Toll-like receptor family. (811 aa)
TBK1TANK binding kinase 1. (729 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
LOC100986336TIR domain-containing protein. (1033 aa)
TLR1Toll-like receptor. (786 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
TNIP1TNFAIP3 interacting protein 1. (645 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
RELREL proto-oncogene, NF-kB subunit. (619 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (805 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
RNF31Uncharacterized protein. (1072 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
LY96MD2 protein. (160 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
NFKBIENFKB inhibitor epsilon. (486 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
IRF7Interferon regulatory factor 7. (516 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
RELBRELB proto-oncogene, NF-kB subunit. (537 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (561 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
TNFAIP3TNF alpha induced protein 3. (784 aa)
TNIP2CCHC NOA-type domain-containing protein. (322 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
IRF3Interferon regulatory factor 3. (452 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
SHARPINSHANK associated RH domain interactor. (387 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (719 aa)
ZBP1Z-DNA binding protein 1. (429 aa)
BCL3BCL3 transcription coactivator. (383 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (625 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1041 aa)
TANKTRAF family member associated NFKB activator. (425 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
ENSPPAP00000035541CCHC NOA-type domain-containing protein. (372 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
TRAF1TNF receptor-associated factor. (416 aa)
NFKBIAANK_REP_REGION domain-containing protein. (456 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.