(18 nodes) MyD88-dependent toll-like receptor signaling pathway, and Toll-like receptor 7 signaling pathway network (Pan paniscus)

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Your Input:
	TICAM2	TIR domain-containing adaptor molecule 2. (235 aa)
	TIRAP	TIR domain-containing protein. (226 aa)
	TLR5	Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
	TLR10	TIR domain-containing protein; Belongs to the Toll-like receptor family. (811 aa)
	LOC100986336	TIR domain-containing protein. (1033 aa)
	TLR1	Toll-like receptor. (786 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (460 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
	LY96	MD2 protein. (160 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
	UNC93B1	Unc-93 homolog B1, TLR signaling regulator. (561 aa)
	IRAK3	Interleukin 1 receptor associated kinase 3. (596 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
	IRAK2	Interleukin 1 receptor associated kinase 2. (625 aa)
	TLR8	Toll-like receptor 8; Belongs to the Toll-like receptor family. (1041 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (712 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IRAK1	IRAK2	ENSPPAP00000034763	ENSPPAP00000031279	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor associated kinase 2.	0.994
IRAK1	IRAK3	ENSPPAP00000034763	ENSPPAP00000026727	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor associated kinase 3.	0.962
IRAK1	IRAK4	ENSPPAP00000034763	ENSPPAP00000009286	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor associated kinase 4.	0.999
IRAK1	LOC100986336	ENSPPAP00000034763	ENSPPAP00000004282	Interleukin 1 receptor associated kinase 1.	TIR domain-containing protein.	0.853
IRAK1	LY96	ENSPPAP00000034763	ENSPPAP00000010406	Interleukin 1 receptor associated kinase 1.	MD2 protein.	0.823
IRAK1	MYD88	ENSPPAP00000034763	ENSPPAP00000029064	Interleukin 1 receptor associated kinase 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.999
IRAK1	TICAM2	ENSPPAP00000034763	ENSPPAP00000000740	Interleukin 1 receptor associated kinase 1.	TIR domain-containing adaptor molecule 2.	0.677
IRAK1	TIRAP	ENSPPAP00000034763	ENSPPAP00000001223	Interleukin 1 receptor associated kinase 1.	TIR domain-containing protein.	0.992
IRAK1	TLR1	ENSPPAP00000034763	ENSPPAP00000004374	Interleukin 1 receptor associated kinase 1.	Toll-like receptor.	0.688
IRAK1	TLR10	ENSPPAP00000034763	ENSPPAP00000003305	Interleukin 1 receptor associated kinase 1.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.460
IRAK1	TLR2	ENSPPAP00000034763	ENSPPAP00000007123	Interleukin 1 receptor associated kinase 1.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.807
IRAK1	TLR3	ENSPPAP00000034763	ENSPPAP00000016321	Interleukin 1 receptor associated kinase 1.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.823
IRAK1	TLR4	ENSPPAP00000034763	ENSPPAP00000016171	Interleukin 1 receptor associated kinase 1.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.835
IRAK1	TLR5	ENSPPAP00000034763	ENSPPAP00000001949	Interleukin 1 receptor associated kinase 1.	Toll-like receptor 5; Belongs to the Toll-like receptor family.	0.766
IRAK1	TLR7	ENSPPAP00000034763	ENSPPAP00000009572	Interleukin 1 receptor associated kinase 1.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.857
IRAK1	TLR8	ENSPPAP00000034763	ENSPPAP00000033784	Interleukin 1 receptor associated kinase 1.	Toll-like receptor 8; Belongs to the Toll-like receptor family.	0.751
IRAK2	IRAK1	ENSPPAP00000031279	ENSPPAP00000034763	Interleukin 1 receptor associated kinase 2.	Interleukin 1 receptor associated kinase 1.	0.994
IRAK2	IRAK3	ENSPPAP00000031279	ENSPPAP00000026727	Interleukin 1 receptor associated kinase 2.	Interleukin 1 receptor associated kinase 3.	0.902
IRAK2	IRAK4	ENSPPAP00000031279	ENSPPAP00000009286	Interleukin 1 receptor associated kinase 2.	Interleukin 1 receptor associated kinase 4.	0.999
IRAK2	LOC100986336	ENSPPAP00000031279	ENSPPAP00000004282	Interleukin 1 receptor associated kinase 2.	TIR domain-containing protein.	0.672