(15 nodes) Autophagy network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100980803	Uncharacterized protein. (117 aa)
	ATG4A	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (398 aa)
	GABARAP	GABA type A receptor-associated protein. (117 aa)
	ATG4D	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (474 aa)
	ATG10	Autophagy related 10. (220 aa)
	ENSPPAP00000023423	Autophagy_N domain-containing protein. (120 aa)
	GABARAPL1	Uncharacterized protein. (117 aa)
	ATG4B	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (393 aa)
	MAP1LC3A	Microtubule associated protein 1 light chain 3 alpha. (125 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (181 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (704 aa)
	ENSPPAP00000035206	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (156 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ATG3	Uncharacterized protein. (158 aa)
	ATG4C	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG10	ATG12	ENSPPAP00000020155	ENSPPAP00000028112	Autophagy related 10.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.997
ATG10	ATG3	ENSPPAP00000020155	ENSPPAP00000037275	Autophagy related 10.	Uncharacterized protein.	0.830
ATG10	ATG4A	ENSPPAP00000020155	ENSPPAP00000004458	Autophagy related 10.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.707
ATG10	ATG4B	ENSPPAP00000020155	ENSPPAP00000025348	Autophagy related 10.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.685
ATG10	ATG4C	ENSPPAP00000020155	ENSPPAP00000041051	Autophagy related 10.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.698
ATG10	ATG4D	ENSPPAP00000020155	ENSPPAP00000017432	Autophagy related 10.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.678
ATG10	ATG5	ENSPPAP00000020155	ENSPPAP00000035390	Autophagy related 10.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.942
ATG10	ATG7	ENSPPAP00000020155	ENSPPAP00000035158	Autophagy related 10.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.987
ATG10	ENSPPAP00000023423	ENSPPAP00000020155	ENSPPAP00000023423	Autophagy related 10.	Autophagy_N domain-containing protein.	0.560
ATG10	ENSPPAP00000035206	ENSPPAP00000020155	ENSPPAP00000035206	Autophagy related 10.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.975
ATG10	GABARAP	ENSPPAP00000020155	ENSPPAP00000013712	Autophagy related 10.	GABA type A receptor-associated protein.	0.609
ATG10	GABARAPL1	ENSPPAP00000020155	ENSPPAP00000024645	Autophagy related 10.	Uncharacterized protein.	0.751
ATG10	MAP1LC3A	ENSPPAP00000020155	ENSPPAP00000028088	Autophagy related 10.	Microtubule associated protein 1 light chain 3 alpha.	0.781
ATG12	ATG10	ENSPPAP00000028112	ENSPPAP00000020155	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy related 10.	0.997
ATG12	ATG3	ENSPPAP00000028112	ENSPPAP00000037275	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Uncharacterized protein.	0.989
ATG12	ATG4A	ENSPPAP00000028112	ENSPPAP00000004458	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.687
ATG12	ATG4B	ENSPPAP00000028112	ENSPPAP00000025348	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.752
ATG12	ATG4C	ENSPPAP00000028112	ENSPPAP00000041051	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.678
ATG12	ATG4D	ENSPPAP00000028112	ENSPPAP00000017432	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.688
ATG12	ATG5	ENSPPAP00000028112	ENSPPAP00000035390	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999