(22 nodes) Mixed, incl. Endodermal cell fate specification, and POU-specific domain network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOX17	SRY-box transcription factor 17. (428 aa)
	NANOG	Putative homeobox protein NANOG2; Probable transcriptional regulator; Belongs to the Nanog homeobox family. (305 aa)
	MIXL1	Homeobox domain-containing protein. (192 aa)
	KLF4	Kruppel like factor 4. (477 aa)
	ENSPPAP00000007988	POU-specific domain-containing protein. (163 aa)
	TBX3	T-box transcription factor 3. (723 aa)
	ENSPPAP00000011491	Homeobox domain-containing protein. (299 aa)
	TBXT	T-box transcription factor T. (435 aa)
	KLF5	Uncharacterized protein. (366 aa)
	FOXA2	Fork-head domain-containing protein. (337 aa)
	ENSPPAP00000021739	Uncharacterized protein. (158 aa)
	EOMES	Eomesodermin. (680 aa)
	ENSPPAP00000024018	Uncharacterized protein. (1204 aa)
	ESRRB	Estrogen related receptor beta. (508 aa)
	LOC100983307	POU domain protein. (263 aa)
	ENSPPAP00000026596	Homeobox domain-containing protein. (290 aa)
	SALL4	Spalt like transcription factor 4. (1053 aa)
	POU5F1	POU domain protein. (360 aa)
	FOXP1	Forkhead box P1. (676 aa)
	ENSPPAP00000032840	Homeobox domain-containing protein. (249 aa)
	SOX2	SRY-box transcription factor 2. (299 aa)
	POU5F1B	POU-specific domain-containing protein. (173 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPPAP00000007988	ENSPPAP00000011491	ENSPPAP00000007988	ENSPPAP00000011491	POU-specific domain-containing protein.	Homeobox domain-containing protein.	0.725
ENSPPAP00000007988	ENSPPAP00000026596	ENSPPAP00000007988	ENSPPAP00000026596	POU-specific domain-containing protein.	Homeobox domain-containing protein.	0.725
ENSPPAP00000007988	ENSPPAP00000032840	ENSPPAP00000007988	ENSPPAP00000032840	POU-specific domain-containing protein.	Homeobox domain-containing protein.	0.725
ENSPPAP00000007988	ESRRB	ENSPPAP00000007988	ENSPPAP00000024705	POU-specific domain-containing protein.	Estrogen related receptor beta.	0.510
ENSPPAP00000007988	FOXA2	ENSPPAP00000007988	ENSPPAP00000016488	POU-specific domain-containing protein.	Fork-head domain-containing protein.	0.446
ENSPPAP00000007988	FOXP1	ENSPPAP00000007988	ENSPPAP00000032729	POU-specific domain-containing protein.	Forkhead box P1.	0.531
ENSPPAP00000007988	KLF4	ENSPPAP00000007988	ENSPPAP00000003618	POU-specific domain-containing protein.	Kruppel like factor 4.	0.731
ENSPPAP00000007988	NANOG	ENSPPAP00000007988	ENSPPAP00000000916	POU-specific domain-containing protein.	Putative homeobox protein NANOG2; Probable transcriptional regulator; Belongs to the Nanog homeobox family.	0.865
ENSPPAP00000007988	SALL4	ENSPPAP00000007988	ENSPPAP00000030110	POU-specific domain-containing protein.	Spalt like transcription factor 4.	0.877
ENSPPAP00000007988	SOX17	ENSPPAP00000007988	ENSPPAP00000000382	POU-specific domain-containing protein.	SRY-box transcription factor 17.	0.531
ENSPPAP00000007988	SOX2	ENSPPAP00000007988	ENSPPAP00000036673	POU-specific domain-containing protein.	SRY-box transcription factor 2.	0.967
ENSPPAP00000007988	TBX3	ENSPPAP00000007988	ENSPPAP00000010916	POU-specific domain-containing protein.	T-box transcription factor 3.	0.460
ENSPPAP00000007988	TBXT	ENSPPAP00000007988	ENSPPAP00000014094	POU-specific domain-containing protein.	T-box transcription factor T.	0.543
ENSPPAP00000011491	ENSPPAP00000007988	ENSPPAP00000011491	ENSPPAP00000007988	Homeobox domain-containing protein.	POU-specific domain-containing protein.	0.725
ENSPPAP00000011491	ENSPPAP00000021739	ENSPPAP00000011491	ENSPPAP00000021739	Homeobox domain-containing protein.	Uncharacterized protein.	0.725
ENSPPAP00000011491	ENSPPAP00000024018	ENSPPAP00000011491	ENSPPAP00000024018	Homeobox domain-containing protein.	Uncharacterized protein.	0.647
ENSPPAP00000011491	EOMES	ENSPPAP00000011491	ENSPPAP00000022091	Homeobox domain-containing protein.	Eomesodermin.	0.456
ENSPPAP00000011491	ESRRB	ENSPPAP00000011491	ENSPPAP00000024705	Homeobox domain-containing protein.	Estrogen related receptor beta.	0.561
ENSPPAP00000011491	FOXP1	ENSPPAP00000011491	ENSPPAP00000032729	Homeobox domain-containing protein.	Forkhead box P1.	0.590
ENSPPAP00000011491	KLF4	ENSPPAP00000011491	ENSPPAP00000003618	Homeobox domain-containing protein.	Kruppel like factor 4.	0.794