(11 nodes) Mostly uncharacterized, incl. PLU-1-like protein, and Embryonic nail plate morphogenesis network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MSX2	Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity). (267 aa)
	LOC100996226	Homeobox domain-containing protein. (312 aa)
	FOXI1	Forkhead box I1. (378 aa)
	PAX9	Paired box 9. (347 aa)
	ENSPPAP00000011186	Homeobox domain-containing protein. (218 aa)
	DLX6	Homeobox domain-containing protein. (165 aa)
	DLX5	Distal-less homeobox 5. (289 aa)
	OSR2	Odd-skipped related transciption factor 2. (433 aa)
	MSX1	Msh homeobox 1. (249 aa)
	PITX2	Homeobox protein. (354 aa)
	KDM5B	Lysine demethylase 5B. (1580 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLX5	DLX6	ENSPPAP00000015904	ENSPPAP00000014706	Distal-less homeobox 5.	Homeobox domain-containing protein.	0.926
DLX5	MSX2	ENSPPAP00000015904	ENSPPAP00000002969	Distal-less homeobox 5.	Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).	0.690
DLX6	DLX5	ENSPPAP00000014706	ENSPPAP00000015904	Homeobox domain-containing protein.	Distal-less homeobox 5.	0.926
ENSPPAP00000011186	MSX1	ENSPPAP00000011186	ENSPPAP00000019486	Homeobox domain-containing protein.	Msh homeobox 1.	0.533
ENSPPAP00000011186	PAX9	ENSPPAP00000011186	ENSPPAP00000011126	Homeobox domain-containing protein.	Paired box 9.	0.473
KDM5B	PAX9	ENSPPAP00000037489	ENSPPAP00000011126	Lysine demethylase 5B.	Paired box 9.	0.732
LOC100996226	MSX1	ENSPPAP00000004875	ENSPPAP00000019486	Homeobox domain-containing protein.	Msh homeobox 1.	0.935
LOC100996226	MSX2	ENSPPAP00000004875	ENSPPAP00000002969	Homeobox domain-containing protein.	Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).	0.901
MSX1	ENSPPAP00000011186	ENSPPAP00000019486	ENSPPAP00000011186	Msh homeobox 1.	Homeobox domain-containing protein.	0.533
MSX1	LOC100996226	ENSPPAP00000019486	ENSPPAP00000004875	Msh homeobox 1.	Homeobox domain-containing protein.	0.935
MSX1	MSX2	ENSPPAP00000019486	ENSPPAP00000002969	Msh homeobox 1.	Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).	0.939
MSX1	OSR2	ENSPPAP00000019486	ENSPPAP00000018793	Msh homeobox 1.	Odd-skipped related transciption factor 2.	0.696
MSX1	PAX9	ENSPPAP00000019486	ENSPPAP00000011126	Msh homeobox 1.	Paired box 9.	0.853
MSX1	PITX2	ENSPPAP00000019486	ENSPPAP00000036121	Msh homeobox 1.	Homeobox protein.	0.427
MSX2	DLX5	ENSPPAP00000002969	ENSPPAP00000015904	Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).	Distal-less homeobox 5.	0.690
MSX2	LOC100996226	ENSPPAP00000002969	ENSPPAP00000004875	Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).	Homeobox domain-containing protein.	0.901
MSX2	MSX1	ENSPPAP00000002969	ENSPPAP00000019486	Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).	Msh homeobox 1.	0.939
MSX2	PAX9	ENSPPAP00000002969	ENSPPAP00000011126	Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).	Paired box 9.	0.558
OSR2	MSX1	ENSPPAP00000018793	ENSPPAP00000019486	Odd-skipped related transciption factor 2.	Msh homeobox 1.	0.696
OSR2	PAX9	ENSPPAP00000018793	ENSPPAP00000011126	Odd-skipped related transciption factor 2.	Paired box 9.	0.605