(12 nodes) Positive regulation of transcription of Notch receptor target, and Delta serrate ligand network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAML3	Mastermind like transcriptional coactivator 3. (935 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (911 aa)
	NOTCH3	Notch receptor 3. (1981 aa)
	NOTCH2	Notch receptor 2. (2254 aa)
	NOTCH4	Notch receptor 4. (2001 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1099 aa)
	MAML2	Mastermind like transcriptional coactivator 2. (1153 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (624 aa)
	RBPJL	Recombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
	NOTCH1	Notch receptor 1. (2573 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (499 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	JAG1	ENSPPAP00000028099	ENSPPAP00000022619	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.695
DLL1	JAG2	ENSPPAP00000028099	ENSPPAP00000015142	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.416
DLL1	MAML1	ENSPPAP00000028099	ENSPPAP00000001220	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 1.	0.612
DLL1	MAML2	ENSPPAP00000028099	ENSPPAP00000021411	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 2.	0.611
DLL1	NOTCH1	ENSPPAP00000028099	ENSPPAP00000033437	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.998
DLL1	NOTCH2	ENSPPAP00000028099	ENSPPAP00000013961	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.995
DLL1	NOTCH3	ENSPPAP00000028099	ENSPPAP00000003870	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.998
DLL1	NOTCH4	ENSPPAP00000028099	ENSPPAP00000014471	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 4.	0.987
DLL1	RBPJ	ENSPPAP00000028099	ENSPPAP00000038680	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.850
DLL1	RBPJL	ENSPPAP00000028099	ENSPPAP00000028515	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region like.	0.467
JAG1	DLL1	ENSPPAP00000022619	ENSPPAP00000028099	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.695
JAG1	JAG2	ENSPPAP00000022619	ENSPPAP00000015142	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.952
JAG1	MAML1	ENSPPAP00000022619	ENSPPAP00000001220	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 1.	0.766
JAG1	MAML2	ENSPPAP00000022619	ENSPPAP00000021411	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 2.	0.702
JAG1	MAML3	ENSPPAP00000022619	ENSPPAP00000000583	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 3.	0.565
JAG1	NOTCH1	ENSPPAP00000022619	ENSPPAP00000033437	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.999
JAG1	NOTCH2	ENSPPAP00000022619	ENSPPAP00000013961	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.995
JAG1	NOTCH3	ENSPPAP00000022619	ENSPPAP00000003870	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.998
JAG1	NOTCH4	ENSPPAP00000022619	ENSPPAP00000014471	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 4.	0.991
JAG1	RBPJ	ENSPPAP00000022619	ENSPPAP00000038680	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.848