(20 nodes) Pyrimidine metabolism network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Input:
	NT5M	Uncharacterized protein. (161 aa)
	DCTD	dCMP deaminase. (180 aa)
	NT5C3A	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (336 aa)
	CMPK1	Uncharacterized protein; Belongs to the adenylate kinase family. (212 aa)
	TK1	Thymidine kinase. (276 aa)
	NT5C1B	Uncharacterized protein. (603 aa)
	NT5C	Uncharacterized protein. (115 aa)
	UPP1	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (310 aa)
	DCTPP1	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (170 aa)
	DCK	dNK domain-containing protein. (317 aa)
	NT5C3B	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa)
	TK2	Thymidine kinase 2. (307 aa)
	UPP2	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (374 aa)
	CMPK2	Uncharacterized protein. (59 aa)
	TYMP	Uncharacterized protein. (145 aa)
	DGUOK	Deoxyguanosine kinase. (277 aa)
	DTYMK	Deoxythymidylate kinase. (212 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
	NT5C1A	5'-nucleotidase, cytosolic IA. (371 aa)
	NT5C2	5'-nucleotidase, cytosolic II. (577 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDA	CMPK2	ENSPPAP00000038685	ENSPPAP00000027773	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Uncharacterized protein.	0.891
CDA	DCK	ENSPPAP00000038685	ENSPPAP00000025963	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	dNK domain-containing protein.	0.986
CDA	DCTD	ENSPPAP00000038685	ENSPPAP00000005427	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	dCMP deaminase.	0.722
CDA	DGUOK	ENSPPAP00000038685	ENSPPAP00000030689	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Deoxyguanosine kinase.	0.655
CDA	DTYMK	ENSPPAP00000038685	ENSPPAP00000036027	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Deoxythymidylate kinase.	0.891
CDA	NT5C	ENSPPAP00000038685	ENSPPAP00000019084	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Uncharacterized protein.	0.914
CDA	NT5C1A	ENSPPAP00000038685	ENSPPAP00000038857	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	5'-nucleotidase, cytosolic IA.	0.911
CDA	NT5C1B	ENSPPAP00000038685	ENSPPAP00000015637	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Uncharacterized protein.	0.904
CDA	NT5C2	ENSPPAP00000038685	ENSPPAP00000042974	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	5'-nucleotidase, cytosolic II.	0.922
CDA	NT5C3A	ENSPPAP00000038685	ENSPPAP00000007398	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family.	0.914
CDA	NT5C3B	ENSPPAP00000038685	ENSPPAP00000026174	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family.	0.916
CDA	NT5M	ENSPPAP00000038685	ENSPPAP00000000170	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Uncharacterized protein.	0.904
CDA	TK1	ENSPPAP00000038685	ENSPPAP00000015455	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Thymidine kinase.	0.990
CDA	TK2	ENSPPAP00000038685	ENSPPAP00000026628	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Thymidine kinase 2.	0.965
CDA	TYMP	ENSPPAP00000038685	ENSPPAP00000028138	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Uncharacterized protein.	0.996
CDA	UPP1	ENSPPAP00000038685	ENSPPAP00000022343	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.	0.995
CDA	UPP2	ENSPPAP00000038685	ENSPPAP00000027322	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.	0.995
CMPK1	CMPK2	ENSPPAP00000008017	ENSPPAP00000027773	Uncharacterized protein; Belongs to the adenylate kinase family.	Uncharacterized protein.	0.969
CMPK1	DCK	ENSPPAP00000008017	ENSPPAP00000025963	Uncharacterized protein; Belongs to the adenylate kinase family.	dNK domain-containing protein.	0.950
CMPK1	DCTD	ENSPPAP00000008017	ENSPPAP00000005427	Uncharacterized protein; Belongs to the adenylate kinase family.	dCMP deaminase.	0.923