(40 nodes) Mixed, incl. Protein folding in endoplasmic reticulum, and Calnexin/calreticulin cycle network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MANF	Mesencephalic astrocyte derived neurotrophic factor. (182 aa)
	CRELD2	Cysteine rich with EGF like domains 2. (364 aa)
	PDILT	Protein disulfide isomerase like, testis expressed. (584 aa)
	MYORG	Myogenesis regulating glycosidase (putative); Belongs to the glycosyl hydrolase 31 family. (714 aa)
	MOGS	Mannosyl-oligosaccharide glucosidase. (837 aa)
	ANKRD45	ANK_REP_REGION domain-containing protein. (266 aa)
	PDIA2	Protein disulfide isomerase family A member 2. (525 aa)
	EDEM1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (592 aa)
	PDIA6	Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family. (505 aa)
	SELENOM	Selenoprotein M. (124 aa)
	PDIA4	Protein disulfide-isomerase A4. (645 aa)
	C9orf24	Chromosome 9 open reading frame 24. (262 aa)
	TXNDC11	Thioredoxin domain containing 11. (956 aa)
	CANX	Calnexin. (592 aa)
	MYDGF	Myeloid derived growth factor. (173 aa)
	SELENOF	Selenoprotein F. (164 aa)
	P4HTM	Prolyl 4-hydroxylase, transmembrane. (529 aa)
	P4HB	Protein disulfide-isomerase. (513 aa)
	SDF2L1	Stromal cell derived factor 2 like 1. (221 aa)
	PRKCSH	Protein kinase C substrate 80K-H. (534 aa)
	ERO1A	Endoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
	EDEM2	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (578 aa)
	ENSPPAP00000025633	Uncharacterized protein. (58 aa)
	SECISBP2L	SECIS binding protein 2 like. (1101 aa)
	UGGT2	UDP-glucose glycoprotein glucosyltransferase 2. (1516 aa)
	EDEM3	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (932 aa)
	ENSPPAP00000030902	Uncharacterized protein. (149 aa)
	TXNDC5	Uncharacterized protein; Belongs to the protein disulfide isomerase family. (361 aa)
	ENSPPAP00000031464	Thioredoxin domain-containing protein. (484 aa)
	SDF2	Stromal cell derived factor 2. (211 aa)
	HSP90B1	Heat shock protein 90 beta family member 1. (814 aa)
	PRDX4	Peroxiredoxin 4. (271 aa)
	UGGT1	UDP-glucose glycoprotein glucosyltransferase 1. (1557 aa)
	CALR3	Calreticulin 3. (352 aa)
	CLGN	Calmegin. (610 aa)
	DNAJC10	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (793 aa)
	ERP29	Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
	DNAJB11	J domain-containing protein. (358 aa)
	GANAB	Glucosidase II alpha subunit; Belongs to the glycosyl hydrolase 31 family. (967 aa)
	ERO1B	Endoplasmic reticulum oxidoreductase 1 beta. (441 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD45	CALR3	ENSPPAP00000009436	ENSPPAP00000033708	ANK_REP_REGION domain-containing protein.	Calreticulin 3.	0.767
ANKRD45	CANX	ENSPPAP00000009436	ENSPPAP00000021763	ANK_REP_REGION domain-containing protein.	Calnexin.	0.742
ANKRD45	CLGN	ENSPPAP00000009436	ENSPPAP00000035152	ANK_REP_REGION domain-containing protein.	Calmegin.	0.742
ANKRD45	DNAJB11	ENSPPAP00000009436	ENSPPAP00000038800	ANK_REP_REGION domain-containing protein.	J domain-containing protein.	0.582
ANKRD45	DNAJC10	ENSPPAP00000009436	ENSPPAP00000035387	ANK_REP_REGION domain-containing protein.	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	0.922
ANKRD45	ENSPPAP00000025633	ENSPPAP00000009436	ENSPPAP00000025633	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.798
ANKRD45	ENSPPAP00000031464	ENSPPAP00000009436	ENSPPAP00000031464	ANK_REP_REGION domain-containing protein.	Thioredoxin domain-containing protein.	0.720
ANKRD45	ERO1A	ENSPPAP00000009436	ENSPPAP00000024994	ANK_REP_REGION domain-containing protein.	Endoplasmic reticulum oxidoreductase 1 alpha.	0.485
ANKRD45	ERO1B	ENSPPAP00000009436	ENSPPAP00000042000	ANK_REP_REGION domain-containing protein.	Endoplasmic reticulum oxidoreductase 1 beta.	0.485
ANKRD45	GANAB	ENSPPAP00000009436	ENSPPAP00000041298	ANK_REP_REGION domain-containing protein.	Glucosidase II alpha subunit; Belongs to the glycosyl hydrolase 31 family.	0.468
ANKRD45	HSP90B1	ENSPPAP00000009436	ENSPPAP00000032136	ANK_REP_REGION domain-containing protein.	Heat shock protein 90 beta family member 1.	0.798
ANKRD45	MANF	ENSPPAP00000009436	ENSPPAP00000003160	ANK_REP_REGION domain-containing protein.	Mesencephalic astrocyte derived neurotrophic factor.	0.652
ANKRD45	MOGS	ENSPPAP00000009436	ENSPPAP00000005075	ANK_REP_REGION domain-containing protein.	Mannosyl-oligosaccharide glucosidase.	0.467
ANKRD45	P4HB	ENSPPAP00000009436	ENSPPAP00000024772	ANK_REP_REGION domain-containing protein.	Protein disulfide-isomerase.	0.720
ANKRD45	PDIA2	ENSPPAP00000009436	ENSPPAP00000010275	ANK_REP_REGION domain-containing protein.	Protein disulfide isomerase family A member 2.	0.720
ANKRD45	PDIA4	ENSPPAP00000009436	ENSPPAP00000016500	ANK_REP_REGION domain-containing protein.	Protein disulfide-isomerase A4.	0.720
ANKRD45	PDIA6	ENSPPAP00000009436	ENSPPAP00000011137	ANK_REP_REGION domain-containing protein.	Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family.	0.441
ANKRD45	PDILT	ENSPPAP00000009436	ENSPPAP00000003917	ANK_REP_REGION domain-containing protein.	Protein disulfide isomerase like, testis expressed.	0.441
ANKRD45	SECISBP2L	ENSPPAP00000009436	ENSPPAP00000026744	ANK_REP_REGION domain-containing protein.	SECIS binding protein 2 like.	0.720
ANKRD45	TXNDC11	ENSPPAP00000009436	ENSPPAP00000017669	ANK_REP_REGION domain-containing protein.	Thioredoxin domain containing 11.	0.720