(22 nodes) Mixed, incl. Protein folding in endoplasmic reticulum, and ER degradation-enhancing alpha-mannosidase-like protein 1/2/3 network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDILT	Protein disulfide isomerase like, testis expressed. (584 aa)
	ANKRD45	ANK_REP_REGION domain-containing protein. (266 aa)
	PDIA2	Protein disulfide isomerase family A member 2. (525 aa)
	EDEM1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (592 aa)
	PDIA6	Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family. (505 aa)
	PDIA4	Protein disulfide-isomerase A4. (645 aa)
	TXNDC11	Thioredoxin domain containing 11. (956 aa)
	CANX	Calnexin. (592 aa)
	P4HB	Protein disulfide-isomerase. (513 aa)
	ERO1A	Endoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
	EDEM2	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (578 aa)
	ENSPPAP00000025633	Uncharacterized protein. (58 aa)
	EDEM3	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (932 aa)
	TXNDC5	Uncharacterized protein; Belongs to the protein disulfide isomerase family. (361 aa)
	ENSPPAP00000031464	Thioredoxin domain-containing protein. (484 aa)
	HSP90B1	Heat shock protein 90 beta family member 1. (814 aa)
	PRDX4	Peroxiredoxin 4. (271 aa)
	CALR3	Calreticulin 3. (352 aa)
	CLGN	Calmegin. (610 aa)
	DNAJC10	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (793 aa)
	ERP29	Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
	ERO1B	Endoplasmic reticulum oxidoreductase 1 beta. (441 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD45	CALR3	ENSPPAP00000009436	ENSPPAP00000033708	ANK_REP_REGION domain-containing protein.	Calreticulin 3.	0.767
ANKRD45	CANX	ENSPPAP00000009436	ENSPPAP00000021763	ANK_REP_REGION domain-containing protein.	Calnexin.	0.742
ANKRD45	CLGN	ENSPPAP00000009436	ENSPPAP00000035152	ANK_REP_REGION domain-containing protein.	Calmegin.	0.742
ANKRD45	DNAJC10	ENSPPAP00000009436	ENSPPAP00000035387	ANK_REP_REGION domain-containing protein.	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	0.922
ANKRD45	ENSPPAP00000025633	ENSPPAP00000009436	ENSPPAP00000025633	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.798
ANKRD45	ENSPPAP00000031464	ENSPPAP00000009436	ENSPPAP00000031464	ANK_REP_REGION domain-containing protein.	Thioredoxin domain-containing protein.	0.720
ANKRD45	ERO1A	ENSPPAP00000009436	ENSPPAP00000024994	ANK_REP_REGION domain-containing protein.	Endoplasmic reticulum oxidoreductase 1 alpha.	0.485
ANKRD45	ERO1B	ENSPPAP00000009436	ENSPPAP00000042000	ANK_REP_REGION domain-containing protein.	Endoplasmic reticulum oxidoreductase 1 beta.	0.485
ANKRD45	HSP90B1	ENSPPAP00000009436	ENSPPAP00000032136	ANK_REP_REGION domain-containing protein.	Heat shock protein 90 beta family member 1.	0.798
ANKRD45	P4HB	ENSPPAP00000009436	ENSPPAP00000024772	ANK_REP_REGION domain-containing protein.	Protein disulfide-isomerase.	0.720
ANKRD45	PDIA2	ENSPPAP00000009436	ENSPPAP00000010275	ANK_REP_REGION domain-containing protein.	Protein disulfide isomerase family A member 2.	0.720
ANKRD45	PDIA4	ENSPPAP00000009436	ENSPPAP00000016500	ANK_REP_REGION domain-containing protein.	Protein disulfide-isomerase A4.	0.720
ANKRD45	PDIA6	ENSPPAP00000009436	ENSPPAP00000011137	ANK_REP_REGION domain-containing protein.	Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family.	0.441
ANKRD45	PDILT	ENSPPAP00000009436	ENSPPAP00000003917	ANK_REP_REGION domain-containing protein.	Protein disulfide isomerase like, testis expressed.	0.441
ANKRD45	TXNDC11	ENSPPAP00000009436	ENSPPAP00000017669	ANK_REP_REGION domain-containing protein.	Thioredoxin domain containing 11.	0.720
ANKRD45	TXNDC5	ENSPPAP00000009436	ENSPPAP00000031402	ANK_REP_REGION domain-containing protein.	Uncharacterized protein; Belongs to the protein disulfide isomerase family.	0.441
CALR3	ANKRD45	ENSPPAP00000033708	ENSPPAP00000009436	Calreticulin 3.	ANK_REP_REGION domain-containing protein.	0.767
CALR3	CANX	ENSPPAP00000033708	ENSPPAP00000021763	Calreticulin 3.	Calnexin.	0.850
CALR3	CLGN	ENSPPAP00000033708	ENSPPAP00000035152	Calreticulin 3.	Calmegin.	0.819
CALR3	DNAJC10	ENSPPAP00000033708	ENSPPAP00000035387	Calreticulin 3.	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	0.732