(40 nodes) Mixed, incl. Sialic acid binding, and Sialic acid metabolism network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106634416	Uncharacterized protein. (144 aa)
	ZNF574	Zinc finger protein 574. (986 aa)
	SIGLEC14	Sialic acid binding Ig like lectin 14. (401 aa)
	SIGLEC12	Sialic acid binding Ig like lectin 12 (gene/pseudogene). (597 aa)
	LOC103785253	Uncharacterized protein. (384 aa)
	SIGLEC15	Sialic acid binding Ig like lectin 15. (309 aa)
	TMEM40	Transmembrane protein 40. (233 aa)
	NANP	N-acetylneuraminic acid phosphatase. (248 aa)
	ST6GALNAC5	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; Belongs to the glycosyltransferase 29 family. (335 aa)
	NANS	N-acetylneuraminate synthase. (359 aa)
	CEACAM16	Carcinoembryonic antigen related cell adhesion molecule 16. (425 aa)
	SSMEM1	Serine rich single-pass membrane protein 1. (229 aa)
	C1orf56	Chromosome 1 open reading frame 56. (341 aa)
	CEACAM4	Carcinoembryonic antigen related cell adhesion molecule 4. (254 aa)
	ST6GALNAC2	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; Belongs to the glycosyltransferase 29 family. (374 aa)
	VSIG10L	V-set and immunoglobulin domain containing 10 like. (806 aa)
	PPRC1	PPARG related coactivator 1. (1637 aa)
	LILRA4	Leukocyte immunoglobulin like receptor A4. (499 aa)
	CDC42EP1	CDC42 effector protein 1. (383 aa)
	ST8SIA4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (359 aa)
	CEACAM19	IGv domain-containing protein. (388 aa)
	PLAC8	Placenta associated 8. (115 aa)
	SIGLEC16	Uncharacterized protein. (510 aa)
	CMAH	Cytidine monophosphate-N-acetylneuraminic acid hydroxylase; Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell- pathogen interactions. Catalyzes the conversion of CMP-N- acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells. (613 aa)
	OR1P1	Olfactory receptor. (344 aa)
	SIGLEC11	Uncharacterized protein. (703 aa)
	CEACAM3	Carcinoembryonic antigen related cell adhesion molecule 3. (252 aa)
	ENSPPAP00000031064	Uncharacterized protein. (169 aa)
	SIGLEC8	Sialic acid binding Ig like lectin 8. (499 aa)
	CCDC136	Coiled-coil domain containing 136. (1145 aa)
	CMAS	Cytidine monophosphate N-acetylneuraminic acid synthetase. (434 aa)
	ENSPPAP00000035079	Uncharacterized protein. (513 aa)
	CEACAM7	IGv domain-containing protein. (172 aa)
	SLC35A1	Solute carrier family 35 member A1. (337 aa)
	ST3GAL3	Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (444 aa)
	FCMR	Fc fragment of IgM receptor. (359 aa)
	MBD6	Methyl-CpG binding domain protein 6. (1003 aa)
	C5orf46	Chromosome 5 open reading frame 46. (87 aa)
	ENSPPAP00000040809	Uncharacterized protein. (297 aa)
	ADGRE5	Adhesion G protein-coupled receptor E5; Belongs to the G-protein coupled receptor 2 family. (743 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRE5	CEACAM4	ENSPPAP00000042716	ENSPPAP00000017287	Adhesion G protein-coupled receptor E5; Belongs to the G-protein coupled receptor 2 family.	Carcinoembryonic antigen related cell adhesion molecule 4.	0.797
ADGRE5	PLAC8	ENSPPAP00000042716	ENSPPAP00000022061	Adhesion G protein-coupled receptor E5; Belongs to the G-protein coupled receptor 2 family.	Placenta associated 8.	0.490
C5orf46	MBD6	ENSPPAP00000038328	ENSPPAP00000037580	Chromosome 5 open reading frame 46.	Methyl-CpG binding domain protein 6.	0.401
C5orf46	SIGLEC16	ENSPPAP00000038328	ENSPPAP00000023039	Chromosome 5 open reading frame 46.	Uncharacterized protein.	0.436
C5orf46	SSMEM1	ENSPPAP00000038328	ENSPPAP00000013195	Chromosome 5 open reading frame 46.	Serine rich single-pass membrane protein 1.	0.431
CCDC136	FCMR	ENSPPAP00000031588	ENSPPAP00000037512	Coiled-coil domain containing 136.	Fc fragment of IgM receptor.	0.467
CCDC136	LOC106634416	ENSPPAP00000031588	ENSPPAP00000000718	Coiled-coil domain containing 136.	Uncharacterized protein.	0.440
CCDC136	MBD6	ENSPPAP00000031588	ENSPPAP00000037580	Coiled-coil domain containing 136.	Methyl-CpG binding domain protein 6.	0.443
CCDC136	PPRC1	ENSPPAP00000031588	ENSPPAP00000018807	Coiled-coil domain containing 136.	PPARG related coactivator 1.	0.467
CCDC136	SIGLEC16	ENSPPAP00000031588	ENSPPAP00000023039	Coiled-coil domain containing 136.	Uncharacterized protein.	0.443
CCDC136	SSMEM1	ENSPPAP00000031588	ENSPPAP00000013195	Coiled-coil domain containing 136.	Serine rich single-pass membrane protein 1.	0.462
CEACAM16	CEACAM19	ENSPPAP00000010875	ENSPPAP00000021665	Carcinoembryonic antigen related cell adhesion molecule 16.	IGv domain-containing protein.	0.518
CEACAM16	LOC106634416	ENSPPAP00000010875	ENSPPAP00000000718	Carcinoembryonic antigen related cell adhesion molecule 16.	Uncharacterized protein.	0.463
CEACAM16	ZNF574	ENSPPAP00000010875	ENSPPAP00000001279	Carcinoembryonic antigen related cell adhesion molecule 16.	Zinc finger protein 574.	0.808
CEACAM19	CEACAM16	ENSPPAP00000021665	ENSPPAP00000010875	IGv domain-containing protein.	Carcinoembryonic antigen related cell adhesion molecule 16.	0.518
CEACAM19	CEACAM3	ENSPPAP00000021665	ENSPPAP00000030572	IGv domain-containing protein.	Carcinoembryonic antigen related cell adhesion molecule 3.	0.409
CEACAM19	CEACAM4	ENSPPAP00000021665	ENSPPAP00000017287	IGv domain-containing protein.	Carcinoembryonic antigen related cell adhesion molecule 4.	0.451
CEACAM19	LOC106634416	ENSPPAP00000021665	ENSPPAP00000000718	IGv domain-containing protein.	Uncharacterized protein.	0.674
CEACAM3	CEACAM19	ENSPPAP00000030572	ENSPPAP00000021665	Carcinoembryonic antigen related cell adhesion molecule 3.	IGv domain-containing protein.	0.409
CEACAM3	LOC106634416	ENSPPAP00000030572	ENSPPAP00000000718	Carcinoembryonic antigen related cell adhesion molecule 3.	Uncharacterized protein.	0.467