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| | PRIM2 | Uncharacterized protein. (158 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3417 aa) |
| | HELQ | Helicase, POLQ like. (1101 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | CHTF8 | Chromosome transmission fidelity factor 8. (121 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (429 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | TDRD3 | Tudor domain containing 3. (744 aa) |
| | PMS1 | PMS1 homolog 1, mismatch repair system component. (932 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (417 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | PMS2 | PMS1 homolog 2, mismatch repair system component. (771 aa) |
| | ENSPPAP00000003540 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | RAD23A | RAD23 homolog A, nucleotide excision repair protein. (363 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (435 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | ENSPPAP00000004814 | RPA_C domain-containing protein. (241 aa) |
| | CHEK1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (476 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | HELB | DNA helicase B. (1087 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1186 aa) |
| | DBF4 | DBF4 zinc finger. (655 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (278 aa) |
| | FANCF | FA complementation group F. (374 aa) |
| | FANCI | FA complementation group I. (1328 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | RBPMS2 | RNA binding protein, mRNA processing factor 2. (180 aa) |
| | WDR76 | WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (625 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1473 aa) |
| | CDC7 | Cell division cycle 7. (574 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (895 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | POLK | DNA polymerase kappa. (897 aa) |
| | RAD51D | RAD51 paralog D. (348 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1143 aa) |
| | POLQ | DNA polymerase theta. (2731 aa) |
| | FANCD2 | FA complementation group D2. (1259 aa) |
| | VWA5B2 | Von Willebrand factor A domain containing 5B2. (1242 aa) |
| | ENSPPAP00000008893 | NTF2 domain-containing protein. (116 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (1047 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (876 aa) |
| | LRWD1 | Leucine rich repeats and WD repeat domain containing 1. (647 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (908 aa) |
| | USP1 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (840 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (774 aa) |
| | CDC45 | Cell division cycle 45. (598 aa) |
| | FANCM | FA complementation group M. (2048 aa) |
| | CLSPN | Claspin. (1338 aa) |
| | ENSPPAP00000012006 | Uncharacterized protein. (319 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (1078 aa) |
| | FSBP | Uncharacterized protein. (896 aa) |
| | CENPX | Centromere protein X. (131 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1312 aa) |
| | ENSPPAP00000013353 | Uncharacterized protein. (117 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) |
| | WDR48 | WD repeat domain 48. (684 aa) |
| | POLD1 | DNA polymerase. (1133 aa) |
| | ORC2 | Origin recognition complex subunit 2. (577 aa) |
| | CHEK2 | FHA domain-containing protein. (229 aa) |
| | ENSPPAP00000014328 | BRCT domain-containing protein. (581 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1832 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (116 aa) |
| | ENSPPAP00000014748 | NTF2 domain-containing protein. (110 aa) |
| | RMI2 | RecQ mediated genome instability 2. (126 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa) |
| | SLX4IP | SLX4 interacting protein. (412 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1849 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1251 aa) |
| | MLH1 | MutL homolog 1. (756 aa) |
| | RAD54L | RAD54 like. (747 aa) |
| | FANCL | FA complementation group L. (355 aa) |
| | FAAP24 | FA core complex associated protein 24. (215 aa) |
| | ENSPPAP00000016638 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (612 aa) |
| | PIEZO2 | Piezo-type mechanosensitive ion channel component. (2677 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (869 aa) |
| | ENSPPAP00000017016 | Uncharacterized protein. (142 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | ENSPPAP00000017787 | FANCA_interact domain-containing protein. (154 aa) |
| | TM4SF19 | Uncharacterized protein. (299 aa) |
| | BLM | BLM RecQ like helicase. (1417 aa) |
| | MEIOB | Uncharacterized protein. (344 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (259 aa) |
| | FANCB | FA complementation group B. (858 aa) |
| | POLI | DNA polymerase iota. (660 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | FANCA | FA complementation group A. (1420 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (301 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | UBE2T | Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (197 aa) |
| | MCM8 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (843 aa) |
| | MSH3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1113 aa) |
| | ENSPPAP00000021658 | Uncharacterized protein. (339 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | DBF4B | DBF4 zinc finger B. (615 aa) |
| | WRNIP1 | WRN helicase interacting protein 1. (572 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (998 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | ENSPPAP00000023005 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (285 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3130 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (692 aa) |
| | LRR1 | Leucine rich repeat protein 1. (414 aa) |
| | FANCE | Uncharacterized protein. (490 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | TIMELESS | Timeless circadian regulator. (1208 aa) |
| | RADX | RPA1 related single stranded DNA binding protein, X-linked. (855 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1103 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | RAD51C | RAD51 paralog C. (376 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (470 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (378 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | ENSPPAP00000026192 | Uncharacterized protein. (86 aa) |
| | ENSPPAP00000026505 | Sld5 domain-containing protein. (168 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (859 aa) |
| | ENSPPAP00000027404 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (246 aa) |
| | WRN | WRN RecQ like helicase. (1405 aa) |
| | ORC3 | Origin recognition complex subunit 3. (712 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1249 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1060 aa) |
| | FANCC | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (543 aa) |
| | ATRIP | ATR interacting protein. (790 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa) |
| | FAAP100 | FA core complex associated protein 100. (796 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (597 aa) |
| | FANCG | FA complementation group G. (622 aa) |
| | PRIMPOL | Uncharacterized protein. (431 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa) |
| | EXO1 | Exonuclease 1. (846 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (348 aa) |
| | ENSPPAP00000031315 | Uncharacterized protein. (560 aa) |
| | CETN2 | Centrin 2. (172 aa) |
| | RECQL4 | RecQ like helicase 4. (1208 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | GINS1 | GINS complex subunit 1. (196 aa) |
| | VWA5B1 | Von Willebrand factor A domain containing 5B1. (1215 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | GMNN | Geminin DNA replication inhibitor. (209 aa) |
| | ENSPPAP00000034946 | Uncharacterized protein. (276 aa) |
| | XPA | XPA, DNA damage recognition and repair factor. (273 aa) |
| | ENSPPAP00000035310 | Uncharacterized protein. (121 aa) |
| | RAD51B | RAD51 paralog B. (359 aa) |
| | RFC2 | Replication factor C subunit 2. (320 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | BIVM | BIVM-ERCC5 readthrough. (1640 aa) |
| | CTC1 | CST telomere replication complex component 1. (1217 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | RAD23B | RAD23 homolog B, nucleotide excision repair protein. (409 aa) |
| | MCMBP | Minichromosome maintenance complex binding protein. (641 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1304 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1017 aa) |
| | RFC1 | Replication factor C subunit 1. (1148 aa) |
| | POLD3 | Uncharacterized protein. (459 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (155 aa) |
| | FEN1-2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (308 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (954 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (146 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2614 aa) |
| | POLN | DNA polymerase nu. (900 aa) |
| | POLA1 | DNA polymerase. (1468 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (777 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (571 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (238 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (946 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1833 aa) |
| | MLH3 | MutL homolog 3. (1450 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa) |
| | LIG1 | DNA ligase. (919 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | TEN1 | Uncharacterized protein. (123 aa) |
| | FBH1 | F-box DNA helicase 1. (1096 aa) |
| | RFC5 | Replication factor C subunit 5. (354 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (681 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1058 aa) |
