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HACD4 HACD4 ENSPPAP00000000919 ENSPPAP00000000919 HACD3 HACD3 CYP4F2 CYP4F2 CYP4F12 CYP4F12 ACOX2 ACOX2 ABCD2 ABCD2 TECR TECR HACD1 HACD1 PEX2 PEX2 ACSBG1 ACSBG1 ELOVL6 ELOVL6 ACSL1 ACSL1 ELOVL5 ELOVL5 ACOX1 ACOX1 ELOVL2 ELOVL2 ACOT4 ACOT4 TECRL TECRL ABCD1 ABCD1 HACD2 HACD2 ABCD3 ABCD3 ACSL6 ACSL6 ACAA1-2 ACAA1-2 ELOVL3 ELOVL3 PEX5 PEX5 SLC27A5 SLC27A5 SLC27A6 SLC27A6 ELOVL4 ELOVL4 ABCD4 ABCD4 SLC27A4 SLC27A4 HSD17B4 HSD17B4 ELOVL1 ELOVL1 ELOVL7 ELOVL7 SLC27A2 SLC27A2 ACAA1 ACAA1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
HACD4Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (232 aa)
ENSPPAP00000000919Uncharacterized protein. (403 aa)
HACD3Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (400 aa)
CYP4F2Cytochrome P450 family 4 subfamily F member 2; Belongs to the cytochrome P450 family. (520 aa)
CYP4F12Cytochrome P450 family 4 subfamily F member 12; Belongs to the cytochrome P450 family. (524 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa)
ABCD2ATP binding cassette subfamily D member 2. (740 aa)
TECRTrans-2,3-enoyl-CoA reductase. (312 aa)
HACD1Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (274 aa)
PEX2Peroxisomal biogenesis factor 2. (305 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (724 aa)
ELOVL6Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (698 aa)
ELOVL5Elongation of very long chain fatty acids protein. (326 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
ELOVL2Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (295 aa)
ACOT4Acyl-CoA thioesterase 4. (420 aa)
TECRLTrans-2,3-enoyl-CoA reductase like. (363 aa)
ABCD1ATP binding cassette subfamily D member 1. (745 aa)
HACD2Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (157 aa)
ABCD3ATP binding cassette subfamily D member 3. (659 aa)
ACSL6AMP-binding domain-containing protein. (714 aa)
ACAA1-2Uncharacterized protein. (111 aa)
ELOVL3Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (270 aa)
PEX5Peroxisomal biogenesis factor 5. (639 aa)
SLC27A5Solute carrier family 27 member 5. (690 aa)
SLC27A6Solute carrier family 27 member 6. (619 aa)
ELOVL4Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (314 aa)
ABCD4ATP binding cassette subfamily D member 4. (606 aa)
SLC27A4Solute carrier family 27 member 4. (647 aa)
HSD17B4Hydroxysteroid 17-beta dehydrogenase 4. (761 aa)
ELOVL1Elongation of very long chain fatty acids protein. (291 aa)
ELOVL7Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0 [...] (281 aa)
SLC27A2Solute carrier family 27 member 2. (620 aa)
ACAA1Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (299 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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