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| | ENSPPAP00000000081 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (369 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3417 aa) |
| | SHLD1 | Shieldin complex subunit 1. (205 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | SMC5 | SMC_N domain-containing protein. (1101 aa) |
| | PTGES3 | Prostaglandin E synthase 3. (164 aa) |
| | GAR1 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (218 aa) |
| | ENSPPAP00000003540 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1088 aa) |
| | INO80D | INO80 complex subunit D. (1027 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (278 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (458 aa) |
| | ZSCAN4 | Zinc finger and SCAN domain-containing protein 4; Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity). (433 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2473 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (437 aa) |
| | ENSPPAP00000042766 | SAP domain-containing protein. (225 aa) |
| | TEN1 | Uncharacterized protein. (123 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1096 aa) |
| | ENSPPAP00000042654 | HTH myb-type domain-containing protein. (247 aa) |
| | DCLRE1A | DNA cross-link repair 1A. (1040 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1833 aa) |
| | INO80E | INO80 complex subunit E. (244 aa) |
| | SP100 | SP100 nuclear antigen. (857 aa) |
| | TERF2 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (472 aa) |
| | TERF2IP | TERF2 interacting protein. (394 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (247 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2614 aa) |
| | ENSPPAP00000040316 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (403 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (954 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (590 aa) |
| | INO80 | INO80 complex ATPase subunit. (1556 aa) |
| | RFC1 | Replication factor C subunit 1. (1148 aa) |
| | TFPT | TCF3 fusion partner. (253 aa) |
| | ENSPPAP00000038467 | FAM35_C domain-containing protein. (224 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | ZNF827 | Zinc finger protein 827. (1079 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (533 aa) |
| | LOC100992102 | CS domain-containing protein. (137 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (539 aa) |
| | CTC1 | CST telomere replication complex component 1. (1217 aa) |
| | MCRS1 | Microspherule protein 1. (475 aa) |
| | ENSPPAP00000035310 | Uncharacterized protein. (121 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (334 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | DKC1 | Dyskerin pseudouridine synthase 1. (514 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | TINF2 | TERF1 interacting nuclear factor 2. (453 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (596 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | NHP2 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa) |
| | ENSPPAP00000011125 | Ribosomal_L7Ae domain-containing protein. (93 aa) |
| | ENSPPAP00000011953 | Ku domain-containing protein. (586 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase. (368 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1040 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1312 aa) |
| | ENSPPAP00000013353 | Uncharacterized protein. (117 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1299 aa) |
| | PINX1 | PIN2 (TERF1) interacting telomerase inhibitor 1. (332 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (532 aa) |
| | TELO2 | Telomere maintenance 2. (837 aa) |
| | ACTL6A | Actin like 6A; Belongs to the actin family. (430 aa) |
| | BLM | BLM RecQ like helicase. (1417 aa) |
| | TPRKB | TP53RK binding protein; Belongs to the CGI121/TPRKB family. (214 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (259 aa) |
| | TEP1 | Telomerase associated protein 1. (2626 aa) |
| | HSP90AB1 | HATPase_c domain-containing protein. (688 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | RTEL1-2 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1103 aa) |
| | ENSPPAP00000022942 | Ku domain-containing protein. (338 aa) |
| | ZNF365 | Uncharacterized protein. (407 aa) |
| | NOP10 | NOP10 ribonucleoprotein. (64 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (692 aa) |
| | LTO1 | Yae1_N domain-containing protein. (221 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | RAD51C | RAD51 paralog C. (376 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | ENSPPAP00000026641 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (435 aa) |
| | YY1 | Uncharacterized protein. (370 aa) |
| | WRN | WRN RecQ like helicase. (1405 aa) |
| | FBXO4 | F-box protein 4. (387 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (440 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1060 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (547 aa) |
| | POT1 | Protection of telomeres 1. (634 aa) |
| | ZBTB48 | Zinc finger and BTB domain containing 48. (688 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1318 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | INO80B | PAPA-1 domain-containing protein. (356 aa) |
| | EXO1 | Exonuclease 1. (846 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (348 aa) |
| | APEX1 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] (318 aa) |
| | RECQL4 | RecQ like helicase 4. (1208 aa) |
| | ENSPPAP00000031860 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (140 aa) |
