STRINGSTRING
ENSPPAP00000027713 ENSPPAP00000027713 ENSPPAP00000009967 ENSPPAP00000009967 TRIM71 TRIM71 TNRC6A TNRC6A C9orf72 C9orf72 TNRC6B TNRC6B HAX1 HAX1 CARHSP1 CARHSP1 ENSPPAP00000012261 ENSPPAP00000012261 ENSPPAP00000015107 ENSPPAP00000015107 MOV10 MOV10 C19orf54 C19orf54 AJUBA AJUBA DCP1B DCP1B APOBEC3G APOBEC3G AGO4 AGO4 DCPS DCPS AGO3 AGO3 DIS3L2 DIS3L2 NANOS3 NANOS3 ZFP36 ZFP36 LSM1 LSM1 LSM2 LSM2 YTHDF2 YTHDF2 EDC4 EDC4 RBPMS RBPMS APOBEC3G-2 APOBEC3G-2 ENSPPAP00000020924 ENSPPAP00000020924 IGF2BP3 IGF2BP3 BTBD2 BTBD2 LSM3 LSM3 PATL1 PATL1 SQSTM1 SQSTM1 ENSPPAP00000022320 ENSPPAP00000022320 BTBD1 BTBD1 IGF2BP2 IGF2BP2 EIF4E2 EIF4E2 DDX6 DDX6 AGO1 AGO1 ENSPPAP00000023984 ENSPPAP00000023984 ELAVL1 ELAVL1 RC3H2 RC3H2 PSMA2 PSMA2 ENSPPAP00000026714 ENSPPAP00000026714 ENSPPAP00000026880 ENSPPAP00000026880 APOBEC3H APOBEC3H EIF4ENIF1 EIF4ENIF1 CNOT7 CNOT7 CNOT9 CNOT9 SHFL SHFL AGO2 AGO2 LIN28A LIN28A LSM6 LSM6 ENSPPAP00000030023 ENSPPAP00000030023 AICDA AICDA ENSPPAP00000031085 ENSPPAP00000031085 ENSPPAP00000031956 ENSPPAP00000031956 LOC100995121 LOC100995121 ENSPPAP00000032433 ENSPPAP00000032433 RC3H1 RC3H1 TRIM5 TRIM5 POLR2G POLR2G LOC100972230 LOC100972230 ENSPPAP00000034250 ENSPPAP00000034250 EDC3 EDC3 SAMD4A SAMD4A IGF2BP1 IGF2BP1 ENSPPAP00000035130 ENSPPAP00000035130 ENSPPAP00000036339 ENSPPAP00000036339 ZC3H12A ZC3H12A ZC3H12D ZC3H12D ENSPPAP00000038150 ENSPPAP00000038150 DCP2 DCP2 PSMC3 PSMC3 SAMD4B SAMD4B CNOT2 CNOT2 LSM14A LSM14A NOCT NOCT DCP1A DCP1A TOP1 TOP1 TRIM21 TRIM21 YTHDF3 YTHDF3 EIF4E EIF4E CNOT8 CNOT8 UPF1 UPF1 ENSPPAP00000042775 ENSPPAP00000042775 PUM1 PUM1 LSM4 LSM4 POLR2D POLR2D NBDY NBDY ENSPPAP00000000701 ENSPPAP00000000701 PAN2 PAN2 LIMD1 LIMD1 YTHDF1 YTHDF1 CNOT1 CNOT1 NANOS2 NANOS2 MEX3B MEX3B CAPRIN1 CAPRIN1 MEX3A MEX3A APOBEC3C APOBEC3C ENSPPAP00000002927 ENSPPAP00000002927 XRN1 XRN1 APOBEC3B APOBEC3B CPEB1 CPEB1 PATL2 PATL2 KIAA0355 KIAA0355 CNOT3 CNOT3 PSMA6 PSMA6 CSDE1 CSDE1 PSMA4 PSMA4 TNRC6C TNRC6C ENSPPAP00000008310 ENSPPAP00000008310 ZFP36L1 ZFP36L1 PSMC2 PSMC2 PAN3 PAN3 SYNE1 SYNE1 ENSPPAP00000009956 ENSPPAP00000009956
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPPAP00000027713ATPase_AAA_core domain-containing protein. (381 aa)
ENSPPAP00000009967Uncharacterized protein. (321 aa)
TRIM71Tripartite motif containing 71. (744 aa)
TNRC6ATrinucleotide repeat containing adaptor 6A. (1965 aa)
C9orf72C9orf72-SMCR8 complex subunit. (478 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (1833 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
CARHSP1Calcium regulated heat stable protein 1. (147 aa)
ENSPPAP00000012261Uncharacterized protein. (663 aa)
ENSPPAP00000015107Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (212 aa)
MOV10Mov10 RISC complex RNA helicase. (1005 aa)
C19orf54Chromosome 19 open reading frame 54. (351 aa)
AJUBAAjuba LIM protein. (538 aa)
DCP1BDecapping mRNA 1B. (621 aa)
APOBEC3GUncharacterized protein. (101 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
DCPSDecapping enzyme, scavenger. (337 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (889 aa)
NANOS3Nanos C2HC-type zinc finger 3; Belongs to the nanos family. (192 aa)
ZFP36ZFP36 ring finger protein. (332 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
LSM2U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (595 aa)
EDC4Enhancer of mRNA decapping 4. (1401 aa)
RBPMSRNA binding protein, mRNA processing factor. (197 aa)
APOBEC3G-2DNA dC->dU-editing enzyme APOBEC-3G; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamin [...] (413 aa)
ENSPPAP00000020924Uncharacterized protein. (353 aa)
IGF2BP3Insulin like growth factor 2 mRNA binding protein 3. (579 aa)
BTBD2BTB domain-containing protein. (377 aa)
LSM3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
PATL1PAT1 homolog 1, processing body mRNA decay factor. (770 aa)
SQSTM1Sequestosome 1. (440 aa)
ENSPPAP00000022320Uncharacterized protein. (203 aa)
BTBD1BTB domain containing 1. (463 aa)
IGF2BP2Insulin like growth factor 2 mRNA binding protein 2. (545 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (249 aa)
DDX6DEAD-box helicase 6; Belongs to the DEAD box helicase family. (483 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
ENSPPAP00000023984RRM domain-containing protein. (528 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
ENSPPAP00000026714Uncharacterized protein. (96 aa)
ENSPPAP00000026880Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (222 aa)
APOBEC3HApolipoprotein B mRNA editing enzyme catalytic subunit 3H. (200 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (985 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (331 aa)
SHFLShiftless antiviral inhibitor of ribosomal frameshifting. (291 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (873 aa)
LIN28ALin-28 homolog A. (209 aa)
LSM6LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (80 aa)
ENSPPAP00000030023RRM domain-containing protein. (486 aa)
AICDAActivation induced cytidine deaminase. (199 aa)
ENSPPAP00000031085Uncharacterized protein. (277 aa)
ENSPPAP00000031956HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (254 aa)
LOC100995121Uncharacterized protein. (542 aa)
ENSPPAP00000032433Uncharacterized protein. (64 aa)
RC3H1Ring finger and CCCH-type domains 1. (1134 aa)
TRIM5Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (493 aa)
POLR2GRNA polymerase II subunit G. (172 aa)
LOC100972230Uncharacterized protein. (458 aa)
ENSPPAP00000034250Uncharacterized protein; Belongs to the DEAD box helicase family. (413 aa)
EDC3Enhancer of mRNA decapping 3. (508 aa)
SAMD4ASterile alpha motif domain containing 4A. (641 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
ENSPPAP00000035130Uncharacterized protein. (433 aa)
ENSPPAP00000036339Uncharacterized protein. (244 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
ZC3H12DZinc finger CCCH-type containing 12D. (526 aa)
ENSPPAP00000038150AAA_lid_3 domain-containing protein. (351 aa)
DCP2Decapping mRNA 2. (417 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
SAMD4BSterile alpha motif domain containing 4B. (694 aa)
CNOT2CCR4-NOT transcription complex subunit 2. (550 aa)
LSM14AUncharacterized protein. (477 aa)
NOCTNocturnin. (394 aa)
DCP1ADecapping mRNA 1A. (582 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (765 aa)
TRIM21Tripartite motif containing 21. (475 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (587 aa)
EIF4EUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (246 aa)
CNOT8CCR4-NOT transcription complex subunit 8. (292 aa)
UPF1UPF1 RNA helicase and ATPase. (1096 aa)
ENSPPAP00000042775Sm domain-containing protein. (81 aa)
PUM1Pumilio RNA binding family member 1. (1216 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (238 aa)
POLR2DRPOL4c domain-containing protein. (110 aa)
NBDYNegative regulator of P-body association. (68 aa)
ENSPPAP00000000701RRM domain-containing protein. (528 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1198 aa)
LIMD1LIM domains containing 1. (676 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (584 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2383 aa)
NANOS2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
MEX3BMex-3 RNA binding family member B. (595 aa)
CAPRIN1Cell cycle associated protein 1. (721 aa)
MEX3AMex-3 RNA binding family member A. (495 aa)
APOBEC3CApolipoprotein B mRNA editing enzyme catalytic subunit 3C. (190 aa)
ENSPPAP00000002927CCHC-type domain-containing protein. (202 aa)
XRN15'-3' exoribonuclease 1. (1706 aa)
APOBEC3BUncharacterized protein. (490 aa)
CPEB1Cytoplasmic polyadenylation element binding protein 1. (626 aa)
PATL2PAT1 homolog 2. (545 aa)
KIAA0355KIAA0355. (1070 aa)
CNOT3CCR4-NOT transcription complex subunit 3. (753 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
TNRC6CTrinucleotide repeat containing adaptor 6C. (1928 aa)
ENSPPAP00000008310Uncharacterized protein. (212 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (432 aa)
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (743 aa)
SYNE1Spectrin repeat containing nuclear envelope protein 1. (8797 aa)
ENSPPAP00000009956Uncharacterized protein. (245 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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