40 items (Pan paniscus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
	RPL23	Uncharacterized protein; Belongs to the universal ribosomal protein uL14 family. (140 aa)
	ENSPPAP00000002277	Uncharacterized protein; Belongs to the universal ribosomal protein uL14 family. (135 aa)
	HAND2	Uncharacterized protein. (66 aa)
	GATA6	Uncharacterized protein. (402 aa)
	HNF1A	HNF1 homeobox A. (662 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	GATA3	GATA binding protein 3. (444 aa)
	GATA2	GATA binding protein 2. (480 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	ZBTB49	Zinc finger and BTB domain containing 49. (765 aa)
	MED25	Mediator complex subunit 25. (747 aa)
	THRB	Uncharacterized protein. (476 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (850 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1040 aa)
	TFAM	Transcription factor A, mitochondrial. (240 aa)
	NFATC1	Nuclear factor of activated T cells 1. (975 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	TRERF1	Transcriptional regulating factor 1. (1208 aa)
	EP300	E1A binding protein p300. (2411 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	GATA1	GATA binding protein 1. (413 aa)
	ZBTB17	Zinc finger and BTB domain containing 17. (807 aa)
	ZBTB8A	Zinc finger and BTB domain containing 8A. (441 aa)
	CDK9	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
	VGLL4	Vestigial like family member 4. (296 aa)
	CIT	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2078 aa)
	EPAS1	Endothelial PAS domain protein 1. (870 aa)
	CCNT2	Cyclin T2; Belongs to the cyclin family. (730 aa)
	RORA	RAR related orphan receptor A. (559 aa)
	CREBBP	CREB binding protein. (2414 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	AR	Androgen receptor. (882 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (467 aa)
	STAT1	Signal transducer and activator of transcription. (759 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1555 aa)
	TEAD2	TEA domain transcription factor 2. (451 aa)
	MED6	Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (249 aa)
	RARA	Uncharacterized protein. (609 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	CDK9	ENSPPAP00000031741	ENSPPAP00000024837	Androgen receptor.	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	0.411
AR	CREBBP	ENSPPAP00000031741	ENSPPAP00000030795	Androgen receptor.	CREB binding protein.	0.905
AR	EP300	ENSPPAP00000031741	ENSPPAP00000019195	Androgen receptor.	E1A binding protein p300.	0.925
AR	ESR1	ENSPPAP00000031741	ENSPPAP00000006837	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.834
AR	HIF1A	ENSPPAP00000031741	ENSPPAP00000010904	Androgen receptor.	Hypoxia inducible factor 1 subunit alpha.	0.669
AR	MED1	ENSPPAP00000031741	ENSPPAP00000035122	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.657
AR	RELA	ENSPPAP00000031741	ENSPPAP00000018755	Androgen receptor.	RELA proto-oncogene, NF-kB subunit.	0.495
AR	RUNX1	ENSPPAP00000031741	ENSPPAP00000000914	Androgen receptor.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.573
AR	SMAD3	ENSPPAP00000031741	ENSPPAP00000021162	Androgen receptor.	Mothers against decapentaplegic homolog.	0.819
AR	SMAD4	ENSPPAP00000031741	ENSPPAP00000009478	Androgen receptor.	Mothers against decapentaplegic homolog.	0.655
AR	STAT1	ENSPPAP00000031741	ENSPPAP00000033854	Androgen receptor.	Signal transducer and activator of transcription.	0.463
CCNT2	CDK9	ENSPPAP00000028038	ENSPPAP00000024837	Cyclin T2; Belongs to the cyclin family.	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	0.999
CCNT2	SMAD4	ENSPPAP00000028038	ENSPPAP00000009478	Cyclin T2; Belongs to the cyclin family.	Mothers against decapentaplegic homolog.	0.467
CDK9	AR	ENSPPAP00000024837	ENSPPAP00000031741	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	Androgen receptor.	0.411
CDK9	CCNT2	ENSPPAP00000024837	ENSPPAP00000028038	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	Cyclin T2; Belongs to the cyclin family.	0.999
CDK9	EP300	ENSPPAP00000024837	ENSPPAP00000019195	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	E1A binding protein p300.	0.538
CDK9	ESR1	ENSPPAP00000024837	ENSPPAP00000006837	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.607
CDK9	MED1	ENSPPAP00000024837	ENSPPAP00000035122	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.990
CDK9	NFKB1	ENSPPAP00000024837	ENSPPAP00000017939	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	Nuclear factor kappa B subunit 1.	0.460
CDK9	RELA	ENSPPAP00000024837	ENSPPAP00000018755	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	RELA proto-oncogene, NF-kB subunit.	0.621