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| | SLC6A4 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa) |
| | SUV39H1 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa) |
| | EDN1 | Endothelin 1. (212 aa) |
| | EGLN1 | Fe2OG dioxygenase domain-containing protein. (341 aa) |
| | PINK1 | PTEN induced kinase 1. (554 aa) |
| | ALKBH5 | AlkB homolog 5, RNA demethylase. (394 aa) |
| | BMP2 | Bone morphogenetic protein 2. (396 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa) |
| | NF1 | Neurofibromin 1. (2839 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | USF1 | Upstream transcription factor 1. (310 aa) |
| | FUNDC1 | FUN14 domain containing 1. (155 aa) |
| | KCNK2 | Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa) |
| | DDR2 | Discoidin domain receptor tyrosine kinase 2. (855 aa) |
| | SUV39H2 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa) |
| | PGF | PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (221 aa) |
| | ENG | Endoglin. (658 aa) |
| | P2RX2 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (405 aa) |
| | AJUBA | Ajuba LIM protein. (538 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | CYP1A1 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa) |
| | VHL | Von Hippel-Lindau tumor suppressor. (213 aa) |
| | ACVRL1 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa) |
| | P4HB | Protein disulfide-isomerase. (513 aa) |
| | FABP1 | Fatty acid binding protein 1. (127 aa) |
| | LOC100977183 | Uncharacterized protein. (448 aa) |
| | CAPN2 | Calpain 2; Belongs to the peptidase C2 family. (700 aa) |
| | NARF | Nuclear prelamin A recognition factor; Belongs to the NARF family. (501 aa) |
| | HSD11B2 | Hydroxysteroid 11-beta dehydrogenase 2. (379 aa) |
| | STOX1 | Storkhead box 1. (885 aa) |
| | PLOD1 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1. (737 aa) |
| | ANGPTL4 | Angiopoietin like 4. (406 aa) |
| | KCND2 | Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (673 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1249 aa) |
| | TH | Tyrosine hydroxylase. (528 aa) |
| | BNIP3L | BCL2 interacting protein 3 like. (219 aa) |
| | CAV1 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa) |
| | RYR1 | Ryanodine receptor 1. (4924 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1196 aa) |
| | NOP53 | Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (427 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | LOC100971459 | Phosphoglycerate kinase. (417 aa) |
| | ANG | Angiogenin; Belongs to the pancreatic ribonuclease family. (147 aa) |
| | EP300 | E1A binding protein p300. (2411 aa) |
| | TM9SF4 | Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (630 aa) |
| | NR4A2 | Nuclear receptor subfamily 4 group A member 2. (598 aa) |
| | ANGPT2 | Angiopoietin 2. (495 aa) |
| | ENSPPAP00000027174 | Uncharacterized protein. (125 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | CHRNB2 | Cholinergic receptor nicotinic beta 2 subunit. (502 aa) |
| | BMP7 | Bone morphogenetic protein 7. (431 aa) |
| | TBL2 | Transducin beta like 2. (447 aa) |
| | IL1A | Interleukin-1; Belongs to the IL-1 family. (271 aa) |
| | PIN1 | Peptidyl-prolyl cis-trans isomerase. (145 aa) |
| | KCNMA1 | Potassium calcium-activated channel subfamily M alpha 1. (1194 aa) |
| | ENSPPAP00000017962 | ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (172 aa) |
| | RGCC | Regulator of cell cycle. (137 aa) |
| | SFRP1 | NTR domain-containing protein. (178 aa) |
| | AQP1 | Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa) |
| | MECP2 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (493 aa) |
| | SLC2A1 | Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | SLC29A1 | Solute carrier family 29 member 1 (Augustine blood group). (498 aa) |
| | EGLN2 | Egl-9 family hypoxia inducible factor 2. (407 aa) |
| | CBFA2T3 | CBFA2/RUNX1 partner transcriptional co-repressor 3. (653 aa) |
| | BCL2 | BCL2 apoptosis regulator. (193 aa) |
| | MLST8 | MTOR associated protein, LST8 homolog. (327 aa) |
| | ENSPPAP00000043144 | ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (141 aa) |
| | ITGA2 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa) |
| | RYR2 | Ryanodine receptor 2. (4948 aa) |
| | NOS1 | Nitric oxide synthase; Produces nitric oxide (NO). (1403 aa) |
| | ENSPPAP00000027030 | DEP domain-containing protein. (1105 aa) |
| | EPAS1 | Endothelial PAS domain protein 1. (870 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | CD38 | CD38 molecule. (300 aa) |
| | CASR | Calcium sensing receptor. (1078 aa) |
| | ERCC3 | ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa) |
| | HMOX1 | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa) |
| | SIRT2 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa) |
| | PLAU | Plasminogen activator, urokinase. (431 aa) |
| | LOC100976996 | Phosphoglycerate kinase. (408 aa) |
| | CIAO3 | Cytosolic iron-sulfur assembly component 3; Belongs to the NARF family. (484 aa) |
| | SLC9A1 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa) |
| | ADIPOQ | Adiponectin, C1Q and collagen domain containing. (286 aa) |
| | PDK3 | Protein-serine/threonine kinase. (417 aa) |
| | PENK | Proenkephalin. (267 aa) |
| | CYGB | GLOBIN domain-containing protein; Belongs to the globin family. (209 aa) |
| | ADAM8 | ADAM metallopeptidase domain 8. (816 aa) |
| | VEGFC | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa) |
| | HIPK2 | Protein kinase domain-containing protein. (954 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (574 aa) |
| | ENSPPAP00000025633 | Uncharacterized protein. (58 aa) |
| | CITED2 | Uncharacterized protein. (179 aa) |
| | UCP3 | Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (312 aa) |
| | PTGS2 | Prostaglandin-endoperoxide synthase 2. (604 aa) |
| | CASP1-2 | CARD domain-containing protein. (95 aa) |
| | BNIP3 | BCL2 interacting protein 3. (252 aa) |
| | FNDC1 | Fibronectin type III domain containing 1. (1891 aa) |
| | CLCA1 | Chloride channel accessory 1. (935 aa) |
| | PDK1 | Protein-serine/threonine kinase. (456 aa) |
| | CRYAB | Crystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa) |
| | DPP4 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (766 aa) |
| | SCFD1 | Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (614 aa) |
| | PLEKHN1 | Pleckstrin homology domain containing N1. (666 aa) |
| | STC2 | Stanniocalcin 2. (302 aa) |
| | HIF3A | Hypoxia inducible factor 3 subunit alpha. (669 aa) |
| | AQP3 | Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1335 aa) |
| | EPO | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa) |
| | PTGIS | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (501 aa) |
| | RBPJ | Recombination signal binding protein for immunoglobulin kappa J region. (499 aa) |
| | ATP7A | ATPase copper transporting alpha. (1500 aa) |
| | OPRD1 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa) |
| | VEGFD | Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa) |
| | CAV3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa) |
| | ALAD | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (330 aa) |
| | CXCR4 | C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (423 aa) |
| | AGTRAP | Angiotensin II receptor associated protein. (159 aa) |
| | TXN2 | Thioredoxin 2. (201 aa) |
| | NPEPPS | ERAP1_C domain-containing protein. (461 aa) |
| | ENDOG | Endonuclease. (188 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (230 aa) |
| | MYOCD | Myocardin. (986 aa) |
| | CXCL12 | SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa) |
| | MT3 | Uncharacterized protein; Belongs to the metallothionein superfamily. Type 1 family. (113 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2700 aa) |
| | SRC | Tyrosine-protein kinase. (458 aa) |
| | ENSPPAP00000035781 | AdoHcyase_NAD domain-containing protein. (405 aa) |
| | ARNT | Aryl hydrocarbon receptor nuclear translocator. (789 aa) |
| | ACTN4 | Actinin alpha 4. (931 aa) |
| | NOL3 | CARD domain-containing protein. (219 aa) |
| | PKLR | Pyruvate kinase; Belongs to the pyruvate kinase family. (574 aa) |
| | NGB | Neuroglobin; Belongs to the globin family. (151 aa) |
| | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa) |
| | KCNK3 | Potassium channel subfamily K member. (378 aa) |
| | SCN2A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa) |
| | UBQLN1 | Ubiquilin 1. (589 aa) |
| | CA9 | Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family. (459 aa) |
| | MGARP | Mitochondria localized glutamic acid rich protein. (240 aa) |
| | MMP2 | Matrix metallopeptidase 2. (664 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (712 aa) |
| | HP1BP3 | Heterochromatin protein 1 binding protein 3. (553 aa) |
| | BBC3 | Uncharacterized protein. (131 aa) |
| | PGK1 | Phosphoglycerate kinase. (400 aa) |
| | NOTCH1 | Notch receptor 1. (2573 aa) |
| | PPARA | Peroxisome proliferator activated receptor alpha. (467 aa) |
| | PLOD2 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (758 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | LOC100995377 | Uncharacterized protein. (557 aa) |
| | RTN4 | Reticulon. (604 aa) |
| | ACAA2 | Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa) |
| | CAT | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa) |
| | HSP90B1 | Heat shock protein 90 beta family member 1. (814 aa) |
| | ENSPPAP00000032115 | Uncharacterized protein. (883 aa) |
| | WDR83 | WD repeat domain 83. (315 aa) |
| | VEGFB | Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (186 aa) |
| | KCNMB1 | Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa) |
| | HK2 | Hexokinase 2. (917 aa) |
| | SLC11A2 | Solute carrier family 11 member 2. (590 aa) |
| | PPARD | Peroxisome proliferator activated receptor delta. (441 aa) |
| | CREBBP | CREB binding protein. (2414 aa) |
| | ADAM15 | ADAM metallopeptidase domain 15. (863 aa) |
| | ADAM17 | ADAM metallopeptidase domain 17. (824 aa) |
| | RORA | RAR related orphan receptor A. (559 aa) |
| | AK4 | Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa) |
| | LONP1 | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (943 aa) |
| | HIF1AN | Hypoxia inducible factor 1 subunit alpha inhibitor. (349 aa) |
| | ERO1A | Endoplasmic reticulum oxidoreductase 1 alpha. (468 aa) |
| | MTHFR | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (697 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | BECN1 | Beclin 1. (450 aa) |
| | LMNA | Lamin A/C; Belongs to the intermediate filament family. (664 aa) |
| | DNMT3A | DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa) |
| | P2RX3 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa) |
| | EDNRA | Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa) |
| | CHRNA4 | Cholinergic receptor nicotinic alpha 4 subunit. (612 aa) |
| | NFE2L2 | Nuclear factor, erythroid 2 like 2. (605 aa) |
| | AHCY | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (447 aa) |
| | MMP14 | Matrix metallopeptidase 14. (582 aa) |
| | PHB2 | Prohibitin. (299 aa) |
| | ABAT | 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (515 aa) |
| | BAD | BCL2 associated agonist of cell death. (168 aa) |
| | SLC8A1 | Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa) |
| | ADM | Adrenomedullin. (185 aa) |
| | LOC100994493 | Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (476 aa) |
| | ARNT2 | Uncharacterized protein. (759 aa) |
| | VASN | Vasorin. (673 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (618 aa) |
| | REST | RE1 silencing transcription factor. (1097 aa) |
| | SLC2A4 | Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa) |
| | UCP2 | Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa) |
| | CPEB1 | Cytoplasmic polyadenylation element binding protein 1. (626 aa) |
| | HYOU1 | Hypoxia up-regulated 1. (999 aa) |
| | CPEB2 | Uncharacterized protein. (547 aa) |
| | CLDN3 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa) |
| | VCAM1 | Vascular cell adhesion molecule 1. (715 aa) |
| | SCAP | SREBF chaperone. (1269 aa) |
| | MPL | MPL proto-oncogene, thrombopoietin receptor. (646 aa) |
| | PDGFA | PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (227 aa) |
| | GATA6 | Uncharacterized protein. (402 aa) |
| | UCN3 | Urocortin 3. (161 aa) |
| | PLAT | Plasminogen activator; Belongs to the peptidase S1 family. (562 aa) |
| | LOC100986914 | Uncharacterized protein. (210 aa) |
| | LOXL2 | Lysyl oxidase like 2. (780 aa) |
| | EGLN3 | Egl-9 family hypoxia inducible factor 3. (239 aa) |
| | FAM167A | Family with sequence similarity 167 member A. (214 aa) |
| | SLC8A3 | Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (210 aa) |
| | THBS1 | Thrombospondin 1. (1173 aa) |
| | NDNF | Neuron derived neurotrophic factor. (568 aa) |
| | TFRC | Transferrin receptor. (773 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | HILPDA | Hypoxia inducible lipid droplet associated. (63 aa) |
| | SOD3 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (240 aa) |
| | NDRG1 | N-myc downstream regulated 1. (394 aa) |
| | LIMD1 | LIM domains containing 1. (676 aa) |
| | PDLIM1 | PDZ and LIM domain 1. (316 aa) |
| | ADA | Adenosine deaminase. (412 aa) |
| | ALAS2 | 5-aminolevulinate synthase. (611 aa) |
| | E2F1 | E2F transcription factor 1. (397 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa) |
| | CHRNA7 | Uncharacterized protein. (511 aa) |
| | SIRT1 | Sirtuin 1. (693 aa) |
| | DDIT4 | DNA damage inducible transcript 4. (232 aa) |
| | TGFBR3 | Transforming growth factor beta receptor 3. (861 aa) |
| | CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa) |
| | SIRT4 | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (316 aa) |
| | ENSPPAP00000008364 | Peptidyl-prolyl cis-trans isomerase. (155 aa) |
| | NKX3-1 | NK3 homeobox 1. (223 aa) |
| | ZFP36L1 | ZFP36 ring finger protein like 1. (338 aa) |
| | GNGT1 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | NPPC | Natriuretic peptide C. (126 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | ANGPT4 | Angiopoietin 4. (503 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2712 aa) |
| | STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | ENSPPAP00000009926 | EF-hand domain-containing protein. (85 aa) |
| | CD24 | CD24 molecule. (129 aa) |
| | HMOX2 | Heme oxygenase 2. (370 aa) |
| | CYBB | Cytochrome b-245 beta chain. (570 aa) |
| | AGER | Advanced glycosylation end-product specific receptor. (420 aa) |
| | SRF | Serum response factor. (414 aa) |
| | HIF1A | Hypoxia inducible factor 1 subunit alpha. (850 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | BACH1 | BTB domain and CNC homolog 1. (736 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa) |
| | HSF1 | Heat shock transcription factor 1. (490 aa) |
| | FAM162A | Family with sequence similarity 162 member A. (149 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (270 aa) |
| | ENSPPAP00000011835 | Uncharacterized protein. (435 aa) |
| | PAM | Peptidylglycine alpha-amidating monooxygenase. (974 aa) |
| | PTEN | Uncharacterized protein. (542 aa) |
| | ENSPPAP00000012297 | Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (453 aa) |
| | STC1 | Stanniocalcin 1. (247 aa) |
| | PSEN2 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (485 aa) |
| | ADSL | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (498 aa) |
| | SLC2A8 | Solute carrier family 2 member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1040 aa) |
| | PML | Uncharacterized protein. (836 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | FMN2 | Uncharacterized protein. (42 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa) |
