(28 nodes) Establishment of planar polarity network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FZD6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
	IFT20	Intraflagellar transport 20. (158 aa)
	TTC8	Tetratricopeptide repeat domain 8. (531 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
	GRHL3	Grainyhead like transcription factor 3. (626 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (243 aa)
	WDR1	WD repeat domain 1. (606 aa)
	ASTN2	Astrotactin 2. (1135 aa)
	BRSK2	BR serine/threonine kinase 2. (707 aa)
	NPHP1	Nephrocystin 1. (729 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	WDPCP	WD repeat containing planar cell polarity effector. (746 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (495 aa)
	INTU	Inturned planar cell polarity protein. (931 aa)
	EXOC5	Exocyst complex component 5. (708 aa)
	CPLANE1	Ciliogenesis and planar polarity effector 1. (3197 aa)
	ENSPPAP00000028319	Uncharacterized protein. (583 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	CELSR1	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2933 aa)
	FOXF2	Uncharacterized protein. (255 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
	RPGRIP1L	RPGRIP1 like. (1309 aa)
	DLG3	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (748 aa)
	FUZ	Fuzzy planar cell polarity protein. (418 aa)
	BRSK1	BR serine/threonine kinase 1. (666 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1386 aa)
	VANGL2	Vang-like protein. (521 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CELSR1	FZD3	ENSPPAP00000029366	ENSPPAP00000018635	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.716
CELSR1	FZD6	ENSPPAP00000029366	ENSPPAP00000024513	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.819
CELSR1	INTU	ENSPPAP00000029366	ENSPPAP00000020068	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Inturned planar cell polarity protein.	0.459
CELSR1	PTK7	ENSPPAP00000029366	ENSPPAP00000033356	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.584
CELSR1	VANGL2	ENSPPAP00000029366	ENSPPAP00000004390	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Vang-like protein.	0.820
CPLANE1	NPHP1	ENSPPAP00000027419	ENSPPAP00000016164	Ciliogenesis and planar polarity effector 1.	Nephrocystin 1.	0.510
CPLANE1	RPGRIP1L	ENSPPAP00000027419	ENSPPAP00000033449	Ciliogenesis and planar polarity effector 1.	RPGRIP1 like.	0.527
CTHRC1	FZD3	ENSPPAP00000010829	ENSPPAP00000018635	Collagen triple helix repeat containing 1.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.569
CTHRC1	VANGL2	ENSPPAP00000010829	ENSPPAP00000004390	Collagen triple helix repeat containing 1.	Vang-like protein.	0.499
DLG3	ERBB4	ENSPPAP00000033659	ENSPPAP00000037551	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	Receptor protein-tyrosine kinase.	0.521
DLG3	VANGL2	ENSPPAP00000033659	ENSPPAP00000004390	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	Vang-like protein.	0.562
ENSPPAP00000028319	IFT20	ENSPPAP00000028319	ENSPPAP00000002275	Uncharacterized protein.	Intraflagellar transport 20.	0.411
ERBB4	DLG3	ENSPPAP00000037551	ENSPPAP00000033659	Receptor protein-tyrosine kinase.	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	0.521
ERBB4	PTK7	ENSPPAP00000037551	ENSPPAP00000033356	Receptor protein-tyrosine kinase.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.490
EXOC5	IFT20	ENSPPAP00000025083	ENSPPAP00000002275	Exocyst complex component 5.	Intraflagellar transport 20.	0.411
FUZ	INTU	ENSPPAP00000038462	ENSPPAP00000020068	Fuzzy planar cell polarity protein.	Inturned planar cell polarity protein.	0.992
FUZ	WDPCP	ENSPPAP00000038462	ENSPPAP00000019297	Fuzzy planar cell polarity protein.	WD repeat containing planar cell polarity effector.	0.955
FZD3	CELSR1	ENSPPAP00000018635	ENSPPAP00000029366	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	0.716
FZD3	CTHRC1	ENSPPAP00000018635	ENSPPAP00000010829	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Collagen triple helix repeat containing 1.	0.569
FZD3	FZD6	ENSPPAP00000018635	ENSPPAP00000024513	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.622