STRINGSTRING
CYP27B1 CYP27B1 EGFR EGFR ITGB8 ITGB8 LHX4 LHX4 PCDH12 PCDH12 CITED2 CITED2 PTK2 PTK2 PTGS2 PTGS2 LEF1 LEF1 GRHL2 GRHL2 STC2 STC2 NCOA1 NCOA1 RBPJ RBPJ RBM15 RBM15 ENSPPAP00000038499 ENSPPAP00000038499 MAPK14 MAPK14 ALKBH1 ALKBH1 RTL8A RTL8A CSF2 CSF2 SNAI1 SNAI1 STK3 STK3 FBN2 FBN2 ARNT ARNT MED1 MED1 AKT1 AKT1 GCM1 GCM1 SPP1 SPP1 APELA APELA TPPP3 TPPP3 NSDHL NSDHL TTPA TTPA SOX15 SOX15 SPINT1 SPINT1 ETV2 ETV2 PPARD PPARD TFEB TFEB VASH1 VASH1 MDFI MDFI HSD17B2 HSD17B2 MAP3K4 MAP3K4 RPS6 RPS6 CITED1 CITED1 VDR VDR DNAJB6 DNAJB6 BPTF BPTF PLCD3 PLCD3 CDX4 CDX4 TAF10 TAF10 HECTD1 HECTD1 ENSPPAP00000026779 ENSPPAP00000026779 WNT7B WNT7B EPAS1 EPAS1 BIRC6 BIRC6 CCN1 CCN1 IGF2 IGF2 LEP LEP ENSPPAP00000024845 ENSPPAP00000024845 CUL7 CUL7 TCF23 TCF23 ENSPPAP00000024530 ENSPPAP00000024530 TMED2 TMED2 ETNK2 ETNK2 E2F8 E2F8 FGFR2 FGFR2 ENSPPAP00000023291 ENSPPAP00000023291 EOMES EOMES HEY2 HEY2 EPOR EPOR ST14 ST14 PTN PTN DAZAP1 DAZAP1 HSP90AB1 HSP90AB1 VASH2 VASH2 CCNF CCNF CDX2 CDX2 HAND1 HAND1 BMP7 BMP7 NODAL NODAL OVOL2 OVOL2 ADAM19 ADAM19 ASH1L ASH1L LHX3 LHX3 BSG BSG NR2F2 NR2F2 TTPAL TTPAL CCDC134 CCDC134 PKD2 PKD2 KRT19 KRT19 CASP8 CASP8 FOSL1 FOSL1 ZFAT ZFAT WNT2 WNT2 NOTCH2 NOTCH2 FBXW8 FBXW8 EGLN1 EGLN1 PEG10 PEG10 ZNF568 ZNF568 PDGFB PDGFB GHSR GHSR CDKN1B CDKN1B PLK4 PLK4 HEY1 HEY1 PRDX3 PRDX3 STC1 STC1 ENSPPAP00000012520 ENSPPAP00000012520 CTSB CTSB ENSPPAP00000011807 ENSPPAP00000011807 PPARG PPARG NDP NDP RTCB RTCB HIF1A HIF1A SP3 SP3 ENSPPAP00000010058 ENSPPAP00000010058 DEDD DEDD GRB2 GRB2 ENSPPAP00000009712 ENSPPAP00000009712 GATA2 GATA2 STK4 STK4 ZFP36L1 ZFP36L1 MEN1 MEN1 SETD2 SETD2 GHRL GHRL RTL5 RTL5 LOC100973600 LOC100973600 PLAC1 PLAC1 PRDM1 PRDM1 ADA ADA JUNB JUNB MAPK1 MAPK1 HS6ST1 HS6ST1 MME MME STOX2 STOX2 GJB5 GJB5 HNF1A HNF1A BMPR2 BMPR2 SOCS3 SOCS3 CEBPA CEBPA RTL1 RTL1 LIF LIF GGNBP2 GGNBP2 RSPO3 RSPO3 IL10 IL10 TEX19 TEX19 BMP5 BMP5 BIRC2 BIRC2 DLX3 DLX3 E2F7 E2F7 ADM ADM HES1 HES1 TRIM28 TRIM28 FZD5 FZD5 HTRA1 HTRA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (757 aa)
LHX4LIM homeobox 4. (390 aa)
PCDH12Protocadherin 12. (1184 aa)
CITED2Uncharacterized protein. (179 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
GRHL2Grainyhead like transcription factor 2. (618 aa)
STC2Stanniocalcin 2. (302 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (499 aa)
RBM15RNA binding motif protein 15. (977 aa)
ENSPPAP0000003849940S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (228 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (389 aa)
RTL8ARetrotransposon Gag like 8A. (92 aa)
CSF2Colony stimulating factor 2. (144 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
STK3Serine/threonine kinase 3. (467 aa)
FBN2Fibrillin 2. (2866 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1555 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
GCM1Glial cells missing transcription factor 1. (436 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
TPPP3Tubulin polymerization promoting protein family member 3. (176 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (373 aa)
TTPAAlpha tocopherol transfer protein. (278 aa)
SOX15SRY-box transcription factor 15. (233 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (529 aa)
ETV2ETS variant 2. (342 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
TFEBTranscription factor EB. (552 aa)
VASH1Vasohibin 1. (365 aa)
MDFIMyoD family inhibitor. (246 aa)
HSD17B2Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (387 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1597 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (247 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
VDRVitamin D receptor. (477 aa)
DNAJB6DnaJ heat shock protein family (Hsp40) member B6. (326 aa)
BPTFBromodomain PHD finger transcription factor. (2855 aa)
PLCD3Phosphoinositide phospholipase C. (737 aa)
CDX4Caudal type homeobox 4. (284 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (186 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
ENSPPAP00000026779Uncharacterized protein. (720 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
BIRC6Baculoviral IAP repeat containing 6. (4915 aa)
CCN1Cellular communication network factor 1. (381 aa)
IGF2Insulin like growth factor 2. (236 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ENSPPAP0000002484540S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (211 aa)
CUL7Cullin 7; Belongs to the cullin family. (1698 aa)
TCF23Transcription factor 23. (214 aa)
ENSPPAP00000024530Thioredoxin domain-containing protein. (217 aa)
TMED2Transmembrane p24 trafficking protein 2. (208 aa)
ETNK2Ethanolamine kinase 2. (394 aa)
E2F8E2F transcription factor 8. (867 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
ENSPPAP00000023291GOLD domain-containing protein; Belongs to the EMP24/GP25L family. (156 aa)
EOMESEomesodermin. (680 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (508 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (849 aa)
PTNPleiotrophin. (172 aa)
DAZAP1DAZ associated protein 1. (397 aa)
HSP90AB1HATPase_c domain-containing protein. (688 aa)
VASH2Vasohibin 2. (290 aa)
CCNFCyclin F; Belongs to the cyclin family. (772 aa)
CDX2Caudal type homeobox 2. (313 aa)
HAND1Heart and neural crest derivatives expressed 1. (219 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
NODALNodal growth differentiation factor. (347 aa)
OVOL2Ovo like zinc finger 2. (225 aa)
ADAM19ADAM metallopeptidase domain 19. (918 aa)
ASH1LASH1 like histone lysine methyltransferase. (2923 aa)
LHX3LIM homeobox 3. (406 aa)
BSGBasigin (Ok blood group). (362 aa)
NR2F2Uncharacterized protein. (333 aa)
TTPALAlpha tocopherol transfer protein like. (342 aa)
CCDC134Coiled-coil domain containing 134. (228 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (788 aa)
KRT19Keratin 19; Belongs to the intermediate filament family. (400 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (496 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
ZFATZinc finger and AT-hook domain containing. (1243 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
NOTCH2Notch receptor 2. (2254 aa)
FBXW8F-box and WD repeat domain containing 8. (597 aa)
EGLN1Fe2OG dioxygenase domain-containing protein. (341 aa)
PEG10CCHC-type domain-containing protein. (766 aa)
ZNF568Uncharacterized protein. (657 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
PLK4Polo like kinase 4. (970 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
PRDX3Peroxiredoxin 3. (256 aa)
STC1Stanniocalcin 1. (247 aa)
ENSPPAP0000001252040S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (205 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
ENSPPAP00000011807GOLD domain-containing protein. (200 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
NDPNorrin cystine knot growth factor NDP. (133 aa)
RTCBRNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. (505 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
SP3Sp3 transcription factor. (721 aa)
ENSPPAP00000010058Uncharacterized protein. (165 aa)
DEDDDeath effector domain containing. (318 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSPPAP0000000971240S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (237 aa)
GATA2GATA binding protein 2. (480 aa)
STK4Serine/threonine kinase 4. (487 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
MEN1Menin 1. (615 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2536 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
RTL5Retrotrans_gag domain-containing protein. (402 aa)
LOC10097360040S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (238 aa)
PLAC1Placenta enriched 1. (212 aa)
PRDM1PR/SET domain 1. (825 aa)
ADAAdenosine deaminase. (412 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (279 aa)
MMEMembrane metalloendopeptidase. (750 aa)
STOX2Storkhead box 2. (926 aa)
GJB5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (273 aa)
HNF1AHNF1 homeobox A. (662 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1012 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
CEBPABZIP domain-containing protein. (141 aa)
RTL1Retrotransposon Gag like 1. (1359 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
GGNBP2Gametogenetin binding protein 2. (699 aa)
RSPO3R-spondin 3. (291 aa)
IL10Interleukin 10. (178 aa)
TEX19Testis expressed 19. (164 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
DLX3Distal-less homeobox 3. (287 aa)
E2F7E2F transcription factor 7. (911 aa)
ADMAdrenomedullin. (185 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
TRIM28Tripartite motif containing 28. (736 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
HTRA1HtrA serine peptidase 1. (480 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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