(47 nodes) Morphogenesis of an epithelial sheet network (Pan paniscus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FLRT3	Fibronectin leucine rich transmembrane protein 3. (649 aa)
	BMP5	Bone morphogenetic protein 5. (454 aa)
	MMP12	Matrix metallopeptidase 12. (470 aa)
	TMEFF2	Transmembrane protein with EGF like and two follistatin like domains 2. (374 aa)
	FLNA	Uncharacterized protein. (2188 aa)
	DVL1	Dishevelled segment polarity protein 1. (674 aa)
	DDR1	Discoidin domain receptor tyrosine kinase 1. (920 aa)
	MEGF8	Multiple EGF like domains 8. (2845 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
	PLET1	Placenta expressed transcript 1. (207 aa)
	HOXB2	Homeobox B2. (356 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
	SRF	Serum response factor. (414 aa)
	ARHGAP12	Rho GTPase activating protein 12. (846 aa)
	LRG1	Leucine rich alpha-2-glycoprotein 1. (347 aa)
	NOTCH2	Notch receptor 2. (2254 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	CD151	Tetraspanin. (253 aa)
	TOR1A	Uncharacterized protein. (283 aa)
	DVL2	Dishevelled segment polarity protein 2. (736 aa)
	RHOA	Uncharacterized protein. (206 aa)
	AJUBA	Ajuba LIM protein. (538 aa)
	RHOC	Ras homolog family member C. (193 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	PDCD10	Programmed cell death 10. (212 aa)
	PHACTR4	Phosphatase and actin regulator. (660 aa)
	TBX20	Uncharacterized protein. (379 aa)
	CEACAM1	Uncharacterized protein. (464 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	LIN7C	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
	ACVRL1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	DAG1	Dystroglycan 1. (895 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1508 aa)
	CCN1	Cellular communication network factor 1. (381 aa)
	MPP5	Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
	ARHGAP24	Rho GTPase activating protein 24. (748 aa)
	ADAM17	ADAM metallopeptidase domain 17. (824 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	PDPN	Podoplanin. (237 aa)
	NOTCH1	Notch receptor 1. (2573 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	HOXB4	Homeobox B4. (251 aa)
	ITGA5	Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1046 aa)
	CARMIL2	Capping protein regulator and myosin 1 linker 2. (1397 aa)
	COL5A1	Collagen type V alpha 1 chain. (1821 aa)
	CD44	CD44 molecule (Indian blood group). (742 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	BMP5	ENSPPAP00000024869	ENSPPAP00000001212	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 5.	0.503
ACVRL1	BMP7	ENSPPAP00000024869	ENSPPAP00000018925	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 7.	0.546
ADAM17	HBEGF	ENSPPAP00000030429	ENSPPAP00000033567	ADAM metallopeptidase domain 17.	Heparin binding EGF like growth factor.	0.578
ADAM17	JAG1	ENSPPAP00000030429	ENSPPAP00000022619	ADAM metallopeptidase domain 17.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.531
ADAM17	NOTCH1	ENSPPAP00000030429	ENSPPAP00000033437	ADAM metallopeptidase domain 17.	Notch receptor 1.	0.974
ADAM17	NOTCH2	ENSPPAP00000030429	ENSPPAP00000013961	ADAM metallopeptidase domain 17.	Notch receptor 2.	0.928
AJUBA	FLNA	ENSPPAP00000016836	ENSPPAP00000003871	Ajuba LIM protein.	Uncharacterized protein.	0.418
ARHGAP24	FLNA	ENSPPAP00000027585	ENSPPAP00000003871	Rho GTPase activating protein 24.	Uncharacterized protein.	0.856
ARHGAP24	RHOA	ENSPPAP00000027585	ENSPPAP00000016816	Rho GTPase activating protein 24.	Uncharacterized protein.	0.417
ARHGAP24	RHOC	ENSPPAP00000027585	ENSPPAP00000018642	Rho GTPase activating protein 24.	Ras homolog family member C.	0.456
ARHGAP35	FLNA	ENSPPAP00000025470	ENSPPAP00000003871	Rho GTPase activating protein 35.	Uncharacterized protein.	0.479
ARHGAP35	RHOA	ENSPPAP00000025470	ENSPPAP00000016816	Rho GTPase activating protein 35.	Uncharacterized protein.	0.967
ARHGAP35	RHOC	ENSPPAP00000025470	ENSPPAP00000018642	Rho GTPase activating protein 35.	Ras homolog family member C.	0.926
BMP5	ACVRL1	ENSPPAP00000001212	ENSPPAP00000024869	Bone morphogenetic protein 5.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.503
BMP7	ACVRL1	ENSPPAP00000018925	ENSPPAP00000024869	Bone morphogenetic protein 7.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.546
BMP7	CD151	ENSPPAP00000018925	ENSPPAP00000014658	Bone morphogenetic protein 7.	Tetraspanin.	0.422
BMP7	CD44	ENSPPAP00000018925	ENSPPAP00000042156	Bone morphogenetic protein 7.	CD44 molecule (Indian blood group).	0.471
CCN1	CD44	ENSPPAP00000025810	ENSPPAP00000042156	Cellular communication network factor 1.	CD44 molecule (Indian blood group).	0.513
CD151	BMP7	ENSPPAP00000014658	ENSPPAP00000018925	Tetraspanin.	Bone morphogenetic protein 7.	0.422
CD151	CD44	ENSPPAP00000014658	ENSPPAP00000042156	Tetraspanin.	CD44 molecule (Indian blood group).	0.591