(24 nodes) Outflow tract septum morphogenesis network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	BMP4	TGF_BETA_2 domain-containing protein. (402 aa)
	ROBO1	Roundabout guidance receptor 1. (1684 aa)
	PARVA	Parvin alpha. (412 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (931 aa)
	LRP2	LDL receptor related protein 2. (4641 aa)
	ROBO2	Roundabout guidance receptor 2. (1439 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (751 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (924 aa)
	GATA6	Uncharacterized protein. (402 aa)
	ZFPM2	Zinc finger protein, FOG family member 2. (1164 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1012 aa)
	SMAD6	Mothers against decapentaplegic homolog. (495 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	TBX2	T-box transcription factor 2. (622 aa)
	NKX2-5	NK2 homeobox 5. (325 aa)
	ENG	Endoglin. (658 aa)
	TBX1	Uncharacterized protein. (447 aa)
	TBX20	Uncharacterized protein. (379 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	FGFR2	Fibroblast growth factor receptor. (822 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMPR1A	ENSPPAP00000011018	ENSPPAP00000033833	TGF_BETA_2 domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.998
BMP4	BMPR2	ENSPPAP00000011018	ENSPPAP00000004120	TGF_BETA_2 domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.997
BMP4	ENG	ENSPPAP00000011018	ENSPPAP00000016080	TGF_BETA_2 domain-containing protein.	Endoglin.	0.412
BMP4	FGF8	ENSPPAP00000011018	ENSPPAP00000034277	TGF_BETA_2 domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.727
BMP4	FGFR2	ENSPPAP00000011018	ENSPPAP00000023314	TGF_BETA_2 domain-containing protein.	Fibroblast growth factor receptor.	0.539
BMP4	GATA6	ENSPPAP00000011018	ENSPPAP00000003349	TGF_BETA_2 domain-containing protein.	Uncharacterized protein.	0.549
BMP4	ISL1	ENSPPAP00000011018	ENSPPAP00000021951	TGF_BETA_2 domain-containing protein.	ISL LIM homeobox 1.	0.481
BMP4	NKX2-5	ENSPPAP00000011018	ENSPPAP00000015856	TGF_BETA_2 domain-containing protein.	NK2 homeobox 5.	0.566
BMP4	SMAD4	ENSPPAP00000011018	ENSPPAP00000009478	TGF_BETA_2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.881
BMP4	SMAD6	ENSPPAP00000011018	ENSPPAP00000008992	TGF_BETA_2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.694
BMP4	TGFBR2	ENSPPAP00000011018	ENSPPAP00000042185	TGF_BETA_2 domain-containing protein.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.529
BMPR1A	BMP4	ENSPPAP00000033833	ENSPPAP00000011018	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF_BETA_2 domain-containing protein.	0.998
BMPR1A	BMPR2	ENSPPAP00000033833	ENSPPAP00000004120	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.992
BMPR1A	ENG	ENSPPAP00000033833	ENSPPAP00000016080	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.549
BMPR1A	SMAD4	ENSPPAP00000033833	ENSPPAP00000009478	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.856
BMPR1A	SMAD6	ENSPPAP00000033833	ENSPPAP00000008992	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.789
BMPR1A	TGFB2	ENSPPAP00000033833	ENSPPAP00000014891	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.532
BMPR1A	TGFBR2	ENSPPAP00000033833	ENSPPAP00000042185	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.734
BMPR2	BMP4	ENSPPAP00000004120	ENSPPAP00000011018	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF_BETA_2 domain-containing protein.	0.997
BMPR2	BMPR1A	ENSPPAP00000004120	ENSPPAP00000033833	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.992