STRINGSTRING
DQX1 DQX1 RAD54L RAD54L ASCC3 ASCC3 CHD2 CHD2 RECQL RECQL DHX9 DHX9 ENSPPAP00000011953 ENSPPAP00000011953 CHD4 CHD4 FANCM FANCM MCM3 MCM3 ENSPPAP00000009744 ENSPPAP00000009744 G3BP1 G3BP1 IGHMBP2 IGHMBP2 POLQ POLQ MCM9 MCM9 PIF1 PIF1 HFM1 HFM1 HELB HELB DHX36 DHX36 MCM6 MCM6 C17orf64 C17orf64 SUB1 SUB1 MCM2 MCM2 HELQ HELQ SETX SETX BRIP1 BRIP1 WRN WRN ERCC3 ERCC3 GTF2F2 GTF2F2 SMARCAD1 SMARCAD1 TWNK TWNK ENSPPAP00000022942 ENSPPAP00000022942 SUPV3L1 SUPV3L1 MCM7 MCM7 RECQL5 RECQL5 WRNIP1 WRNIP1 ERCC2 ERCC2 FBH1 FBH1 ENSPPAP00000042766 ENSPPAP00000042766 UPF1 UPF1 ATRX ATRX CHD6 CHD6 CHD1 CHD1 ENSPPAP00000039065 ENSPPAP00000039065 DDX3X DDX3X MCM5 MCM5 RAD51 RAD51 CHD8 CHD8 RUVBL1 RUVBL1 ENSPPAP00000034340 ENSPPAP00000034340 CHD9 CHD9 ERCC6L ERCC6L TM4SF19 TM4SF19 BLM BLM XRCC5 XRCC5 ENSPPAP00000019077 ENSPPAP00000019077 CHD3 CHD3 CHD7 CHD7 CHD1L CHD1L RECQL4 RECQL4 RAD54L2 RAD54L2 RUVBL2 RUVBL2 RTEL1 RTEL1 XRCC6 XRCC6 DNA2 DNA2 MCM4 MCM4 RTEL1-2 RTEL1-2 ENSPPAP00000020688 ENSPPAP00000020688 MCM8 MCM8 NAV2 NAV2 CHD5 CHD5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DQX1DEAQ-box RNA dependent ATPase 1. (732 aa)
RAD54LRAD54 like. (747 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3. (2202 aa)
CHD2Uncharacterized protein. (1820 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (635 aa)
DHX9DExH-box helicase 9. (1270 aa)
ENSPPAP00000011953Ku domain-containing protein. (586 aa)
CHD4Uncharacterized protein. (1914 aa)
FANCMFA complementation group M. (2048 aa)
MCM3DNA helicase; Belongs to the MCM family. (840 aa)
ENSPPAP00000009744Uncharacterized protein. (495 aa)
G3BP1G3BP stress granule assembly factor 1. (466 aa)
IGHMBP2Immunoglobulin mu DNA binding protein 2. (997 aa)
POLQDNA polymerase theta. (2731 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1143 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (596 aa)
HFM1Helicase for meiosis 1. (1324 aa)
HELBDNA helicase B. (1087 aa)
DHX36DEAH-box helicase 36. (1009 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
C17orf64Chromosome 17 open reading frame 64. (236 aa)
SUB1SUB1 regulator of transcription. (127 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
HELQHelicase, POLQ like. (1101 aa)
SETXSenataxin. (2669 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1249 aa)
WRNWRN RecQ like helicase. (1405 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
SMARCAD1Uncharacterized protein. (1026 aa)
TWNKTwinkle mtDNA helicase. (582 aa)
ENSPPAP00000022942Ku domain-containing protein. (338 aa)
SUPV3L1Suv3 like RNA helicase. (786 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (998 aa)
WRNIP1WRN helicase interacting protein 1. (572 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
FBH1F-box DNA helicase 1. (1096 aa)
ENSPPAP00000042766SAP domain-containing protein. (225 aa)
UPF1UPF1 RNA helicase and ATPase. (1096 aa)
ATRXATRX chromatin remodeler. (2492 aa)
CHD6Chromodomain helicase DNA binding protein 6. (2687 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1699 aa)
ENSPPAP00000039065Uncharacterized protein. (350 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2573 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
ENSPPAP00000034340NTF2 domain-containing protein. (394 aa)
CHD9Uncharacterized protein. (2383 aa)
ERCC6LERCC excision repair 6 like, spindle assembly checkpoint helicase. (1250 aa)
TM4SF19Uncharacterized protein. (299 aa)
BLMBLM RecQ like helicase. (1417 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
ENSPPAP00000019077Uncharacterized protein. (54 aa)
CHD3Chromodomain helicase DNA binding protein 3. (2012 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (921 aa)
RECQL4RecQ like helicase 4. (1208 aa)
RAD54L2RAD54 like 2. (1467 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1318 aa)
XRCC6X-ray repair cross complementing 6. (547 aa)
DNA2DNA replication helicase/nuclease 2. (1060 aa)
MCM4DNA helicase; Belongs to the MCM family. (869 aa)
RTEL1-2Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1103 aa)
ENSPPAP00000020688Uncharacterized protein. (80 aa)
MCM8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (843 aa)
NAV2Neuron navigator 2. (2488 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1928 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.