STRINGSTRING
ENSPPAP00000035310 ENSPPAP00000035310 MPG MPG RAD23B RAD23B MSH6 MSH6 LOC100989432 LOC100989432 DCLRE1C DCLRE1C XPC XPC ERCC1 ERCC1 DCLRE1A DCLRE1A ENSPPAP00000042766 ENSPPAP00000042766 ERCC2 ERCC2 ENSPPAP00000043136 ENSPPAP00000043136 OGG1 OGG1 CREBBP CREBBP XRCC1 XRCC1 APEX1 APEX1 RECQL4 RECQL4 ENSPPAP00000033446 ENSPPAP00000033446 RPA1 RPA1 NEIL1 NEIL1 DDB2 DDB2 NTHL1 NTHL1 POLB POLB PNKP PNKP ENSPPAP00000003045 ENSPPAP00000003045 ENSPPAP00000003540 ENSPPAP00000003540 SMC6 SMC6 RAD23A RAD23A NBN NBN ENSPPAP00000004806 ENSPPAP00000004806 UNG UNG RBBP8 RBBP8 FEN1 FEN1 POLK POLK POLQ POLQ RAD1 RAD1 ENSPPAP00000011953 ENSPPAP00000011953 RPS3 RPS3 FANCG FANCG POLH POLH RPA3 RPA3 TP63 TP63 SDE2 SDE2 POT1 POT1 XRCC6 XRCC6 NEIL2 NEIL2 WRN WRN ENSPPAP00000026192 ENSPPAP00000026192 ERCC3 ERCC3 RAD18 RAD18 ERCC4 ERCC4 DDB1 DDB1 NEIL3 NEIL3 ENSPPAP00000022942 ENSPPAP00000022942 SIRT6 SIRT6 MSH2 MSH2 CRY2 CRY2 ENSPPAP00000020965 ENSPPAP00000020965 PCNA PCNA POLI POLI EP300 EP300 XRCC5 XRCC5 BLM BLM TDG TDG AUNIP AUNIP ENSPPAP00000016729 ENSPPAP00000016729 DCLRE1B DCLRE1B REV1 REV1 BRCA1 BRCA1 APTX APTX MUTYH MUTYH POLD1 POLD1 ENSPPAP00000013353 ENSPPAP00000013353 TP53BP1 TP53BP1 XPA XPA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPPAP00000035310Uncharacterized protein. (121 aa)
MPGN-methylpurine DNA glycosylase. (284 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (409 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1304 aa)
LOC100989432UDG domain-containing protein. (405 aa)
DCLRE1CDNA cross-link repair 1C. (590 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (946 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
DCLRE1ADNA cross-link repair 1A. (1040 aa)
ENSPPAP00000042766SAP domain-containing protein. (225 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
ENSPPAP00000043136FPG-type domain-containing protein. (297 aa)
OGG1ENDO3c domain-containing protein. (345 aa)
CREBBPCREB binding protein. (2414 aa)
XRCC1X-ray repair cross complementing 1. (556 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] (318 aa)
RECQL4RecQ like helicase 4. (1208 aa)
ENSPPAP00000033446KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (253 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
NEIL1Nei like DNA glycosylase 1. (390 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
ENSPPAP00000003045XRCC1_N domain-containing protein. (141 aa)
ENSPPAP00000003540Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa)
SMC6Structural maintenance of chromosomes 6. (1088 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (363 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
ENSPPAP00000004806Uncharacterized protein. (142 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (313 aa)
RBBP8RB binding protein 8, endonuclease. (895 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
POLKDNA polymerase kappa. (897 aa)
POLQDNA polymerase theta. (2731 aa)
RAD1RAD1 checkpoint DNA exonuclease. (282 aa)
ENSPPAP00000011953Ku domain-containing protein. (586 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
FANCGFA complementation group G. (622 aa)
POLHDNA polymerase eta. (712 aa)
RPA3Replication protein A3. (121 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
SDE2SDE2 telomere maintenance homolog. (451 aa)
POT1Protection of telomeres 1. (634 aa)
XRCC6X-ray repair cross complementing 6. (547 aa)
NEIL2Nei like DNA glycosylase 2. (384 aa)
WRNWRN RecQ like helicase. (1405 aa)
ENSPPAP00000026192Uncharacterized protein. (86 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (495 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
NEIL3Nei like DNA glycosylase 3. (598 aa)
ENSPPAP00000022942Ku domain-containing protein. (338 aa)
SIRT6Sirtuin 6. (355 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
CRY2Cryptochrome circadian regulator 2. (614 aa)
ENSPPAP00000020965KH type-2 domain-containing protein. (250 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
POLIDNA polymerase iota. (660 aa)
EP300E1A binding protein p300. (2411 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
BLMBLM RecQ like helicase. (1417 aa)
TDGThymine DNA glycosylase. (410 aa)
AUNIPAurora kinase A and ninein interacting protein. (371 aa)
ENSPPAP00000016729Ribosomal_S3_C domain-containing protein. (100 aa)
DCLRE1BDNA cross-link repair 1B. (532 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1251 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1849 aa)
APTXAprataxin. (354 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (612 aa)
POLD1DNA polymerase. (1133 aa)
ENSPPAP00000013353Uncharacterized protein. (117 aa)
TP53BP1Tumor protein p53 binding protein 1. (1977 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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