STRINGSTRING
TNKS TNKS FAM162A FAM162A VWA5B2 VWA5B2 SIRT4 SIRT4 ART5 ART5 PARP9 PARP9 PARP6 PARP6 FAM162B FAM162B PARP10 PARP10 PARP1 PARP1 PARP3 PARP3 TNKS2 TNKS2 PARP14 PARP14 ENSPPAP00000000014 ENSPPAP00000000014 PARP4 PARP4 VWA5B1 VWA5B1 ZC3HAV1 ZC3HAV1 ART3 ART3 VWA5A VWA5A SIRT2 SIRT2 PARP2 PARP2 SIRT6 SIRT6 SIRT3 SIRT3 ANKRD39 ANKRD39 PARP15 PARP15 ART4 ART4 SIRT5 SIRT5 PARP16 PARP16 PARP8 PARP8 PARP12 PARP12 ART1 ART1 TIPARP TIPARP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
FAM162AFamily with sequence similarity 162 member A. (149 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1242 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (316 aa)
ART5NAD(P)(+)--arginine ADP-ribosyltransferase. (291 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (855 aa)
PARP6Poly [ADP-ribose] polymerase. (630 aa)
FAM162BFamily with sequence similarity 162 member B. (162 aa)
PARP10Poly [ADP-ribose] polymerase. (1037 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
PARP3Poly [ADP-ribose] polymerase. (539 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
PARP14Poly [ADP-ribose] polymerase. (1801 aa)
ENSPPAP00000000014Uncharacterized protein. (52 aa)
PARP4Poly [ADP-ribose] polymerase. (1724 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1215 aa)
ZC3HAV1Uncharacterized protein. (1024 aa)
ART3NAD(P)(+)--arginine ADP-ribosyltransferase. (369 aa)
VWA5AVon Willebrand factor A domain containing 5A. (786 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
PARP2Poly [ADP-ribose] polymerase. (565 aa)
SIRT6Sirtuin 6. (355 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (342 aa)
ANKRD39ANK_REP_REGION domain-containing protein. (240 aa)
PARP15Poly [ADP-ribose] polymerase. (616 aa)
ART4NAD(P)(+)--arginine ADP-ribosyltransferase. (329 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa)
PARP16Poly [ADP-ribose] polymerase. (323 aa)
PARP8Poly [ADP-ribose] polymerase. (854 aa)
PARP12Poly(ADP-ribose) polymerase family member 12. (641 aa)
ART1NAD(P)(+)--arginine ADP-ribosyltransferase. (327 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (657 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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