STRINGSTRING
SLFN13 SLFN13 PELO PELO APEX1 APEX1 EXO1 EXO1 ENSPPAP00000031085 ENSPPAP00000031085 EXOSC10 EXOSC10 SAMHD1 SAMHD1 INTS11 INTS11 RCL1 RCL1 AGO2 AGO2 ENSPPAP00000029659 ENSPPAP00000029659 ANKLE1 ANKLE1 MBLAC1 MBLAC1 DROSHA DROSHA HELZ2 HELZ2 PLSCR1 PLSCR1 LRRC27 LRRC27 ATRIP ATRIP CNOT7 CNOT7 ERN2 ERN2 DNASE1L2 DNASE1L2 DNA2 DNA2 TSEN34 TSEN34 WRN WRN ENDOU ENDOU PPP1R8 PPP1R8 ELAC1 ELAC1 NUDT12 NUDT12 AZGP1 AZGP1 TATDN3 TATDN3 MBD4 MBD4 ENSPPAP00000026192 ENSPPAP00000026192 ENDOD1 ENDOD1 ERCC4 ERCC4 EME2 EME2 EXOSC4 EXOSC4 APEX2 APEX2 REXO1 REXO1 ENSPPAP00000025163 ENSPPAP00000025163 RAD51C RAD51C DNASE1 DNASE1 TSEN2 TSEN2 DICER1 DICER1 REXO5 REXO5 MRE11 MRE11 N4BP1 N4BP1 EXOSC2 EXOSC2 PDE12 PDE12 ENDOV ENDOV ENSPPAP00000022929 ENSPPAP00000022929 PXDNL PXDNL KHNYN KHNYN HAUS7 HAUS7 ENSPPAP00000022078 ENSPPAP00000022078 RNASEH1 RNASEH1 LAS1L LAS1L DNASE2 DNASE2 UBXN8 UBXN8 POLE POLE ENSPPAP00000020965 ENSPPAP00000020965 APLF APLF XRN2 XRN2 ENSPPAP00000020590 ENSPPAP00000020590 PIWIL2 PIWIL2 RNASE6 RNASE6 RNASE7 RNASE7 N4BP2 N4BP2 RNASE2 RNASE2 RNASE4 RNASE4 RNASE12 RNASE12 TSN TSN EXOG EXOG ANG ANG ERI1 ERI1 MRPL44 MRPL44 TATDN1 TATDN1 MEIOB MEIOB CNOT6 CNOT6 DIS3L2 DIS3L2 AGO3 AGO3 PIWIL3 PIWIL3 ENPP2 ENPP2 DCPS DCPS AGO4 AGO4 RNASET2 RNASET2 ENPP1 ENPP1 NUDT16 NUDT16 PARN PARN ENSPPAP00000016729 ENSPPAP00000016729 ENSPPAP00000016638 ENSPPAP00000016638 DCLRE1B DCLRE1B ANGEL2 ANGEL2 DBR1 DBR1 DNASE2B DNASE2B ISG20L2 ISG20L2 ERN1 ERN1 RAD9A RAD9A TSEN15 TSEN15 YBEY YBEY ENSPPAP00000015279 ENSPPAP00000015279 TSNAX TSNAX APTX APTX CNOT6L CNOT6L POLD1 POLD1 PLD6 PLD6 EXOSC3 EXOSC3 RIDA RIDA RNASEL RNASEL ZRANB3 ZRANB3 TATDN2 TATDN2 TDP1 TDP1 ANGEL1 ANGEL1 OGG1 OGG1 RPS3 RPS3 TDP2 TDP2 MGME1 MGME1 FANCM FANCM ISG20 ISG20 NYNRIN NYNRIN PGBD5 PGBD5 RAD1 RAD1 ERI2 ERI2 GEN1 GEN1 ENSPPAP00000009956 ENSPPAP00000009956 RNASEH2A RNASEH2A ASTE1 ASTE1 REXO4 REXO4 G3BP1 G3BP1 DDX1 DDX1 ENSPPAP00000007423 ENSPPAP00000007423 PNLDC1 PNLDC1 SLFN12L SLFN12L FEN1 FEN1 RBBP8 RBBP8 TTC38 TTC38 PNPT1 PNPT1 MUS81 MUS81 EXOSC5 EXOSC5 RPP40 RPP40 TRIR TRIR TREX1 TREX1 RNASE8 RNASE8 SWT1 SWT1 ENSPPAP00000004806 ENSPPAP00000004806 DIS3L DIS3L RNASE11 RNASE11 ERVMER34-1 ERVMER34-1 PLD3 PLD3 PIWIL1 PIWIL1 POP1 POP1 POP7 POP7 PMS2 PMS2 LACTB2 LACTB2 DNASE1L1 DNASE1L1 PNKP PNKP ELAC2 ELAC2 DFFB DFFB XRN1 XRN1 RPP25 RPP25 SLX1A SLX1A SLFN12 SLFN12 RAD9B RAD9B RNASE1 RNASE1 ENPP3 ENPP3 NTHL1 NTHL1 LOC100978496 LOC100978496 ZGRF1 ZGRF1 ENSPPAP00000000720 ENSPPAP00000000720 PAN2 PAN2 EXOSC9 EXOSC9 RPP30 RPP30 RAG1 RAG1 POP5 POP5 DCLRE1A DCLRE1A CNOT8 CNOT8 EXOSC7 EXOSC7 TSEN54 TSEN54 TOE1 TOE1 SMG6 SMG6 EME1 EME1 POLG POLG SND1 SND1 NOCT NOCT ERI3 ERI3 DNASE1L3 DNASE1L3 CPSF3 CPSF3 EXD3 EXD3 FEN1-2 FEN1-2 EXD2 EXD2 DCLRE1C DCLRE1C ARID3A ARID3A USB1 USB1 DCP2 DCP2 EQTN EQTN FAN1 FAN1 ZC3H12C ZC3H12C PLD4 PLD4 DIS3 DIS3 RPP38 RPP38 C12orf10 C12orf10 ZC3H12D ZC3H12D DXO DXO ENDOG ENDOG RPP14 RPP14 MARF1 MARF1 ZC3H12A ZC3H12A ENSPPAP00000036339 ENSPPAP00000036339 PRORP PRORP BIVM BIVM N4BP2L1 N4BP2L1 ENSPPAP00000035415 ENSPPAP00000035415 POP4 POP4 ENSPPAP00000034890 ENSPPAP00000034890 NOB1 NOB1 ENSPPAP00000034340 ENSPPAP00000034340 SETMAR SETMAR REXO2 REXO2 AEN AEN ENSPPAP00000033446 ENSPPAP00000033446 ZC3H12B ZC3H12B RNASEK RNASEK
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
SLFN13Schlafen family member 13. (897 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] (318 aa)
EXO1Exonuclease 1. (846 aa)
ENSPPAP00000031085Uncharacterized protein. (277 aa)
EXOSC10Exosome component 10. (890 aa)
SAMHD1SAM domain and HD domain-containing protein 1. (626 aa)
INTS11Integrator complex subunit 11. (606 aa)
RCL1RNA terminal phosphate cyclase like 1. (373 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (873 aa)
ENSPPAP00000029659Uncharacterized protein. (176 aa)
ANKLE1Ankyrin repeat and LEM domain containing 1. (669 aa)
MBLAC1Metallo-beta-lactamase domain containing 1. (250 aa)
DROSHADrosha ribonuclease III. (1369 aa)
HELZ2Helicase with zinc finger 2. (2649 aa)
PLSCR1Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (314 aa)
LRRC27Leucine rich repeat containing 27. (530 aa)
ATRIPATR interacting protein. (790 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (926 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (299 aa)
DNA2DNA replication helicase/nuclease 2. (1060 aa)
TSEN34tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (315 aa)
WRNWRN RecQ like helicase. (1405 aa)
ENDOUEndonuclease, poly(U) specific. (433 aa)
PPP1R8Protein phosphatase 1 regulatory subunit 8. (349 aa)
ELAC1ElaC ribonuclease Z 1. (363 aa)
NUDT12Nudix hydrolase 12. (462 aa)
AZGP1Alpha-2-glycoprotein 1, zinc-binding; Belongs to the MHC class I family. (298 aa)
TATDN3TatD DNase domain containing 3. (274 aa)
MBD4Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (574 aa)
ENSPPAP00000026192Uncharacterized protein. (86 aa)
ENDOD1Endonuclease domain containing 1. (500 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (378 aa)
EXOSC4Exosome component 4. (245 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa)
REXO1RNA exonuclease 1 homolog. (1207 aa)
ENSPPAP00000025163Uncharacterized protein. (525 aa)
RAD51CRAD51 paralog C. (376 aa)
DNASE1Deoxyribonuclease; Belongs to the DNase I family. (282 aa)
TSEN2tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (464 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1922 aa)
REXO5RNA exonuclease 5. (774 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (692 aa)
N4BP1NEDD4 binding protein 1. (896 aa)
EXOSC2Exosome component 2. (293 aa)
PDE12Phosphodiesterase 12. (608 aa)
ENDOVEndonuclease V. (309 aa)
ENSPPAP00000022929tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (392 aa)
PXDNLPeroxidasin like. (1441 aa)
KHNYNKH and NYN domain containing. (678 aa)
HAUS7HAUS augmin like complex subunit 7. (381 aa)
ENSPPAP00000022078Endo/exonuclease/phosphatase domain-containing protein. (470 aa)
RNASEH1Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (286 aa)
LAS1LLAS1 like, ribosome biogenesis factor. (731 aa)
DNASE2Deoxyribonuclease 2, lysosomal. (360 aa)
UBXN8UBX domain protein 8. (298 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa)
ENSPPAP00000020965KH type-2 domain-containing protein. (250 aa)
APLFAprataxin and PNKP like factor. (511 aa)
XRN25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (950 aa)
ENSPPAP00000020590Uncharacterized protein. (74 aa)
PIWIL2Uncharacterized protein; Belongs to the argonaute family. (974 aa)
RNASE6Ribonuclease A family member k6; Belongs to the pancreatic ribonuclease family. (150 aa)
RNASE7Ribonuclease A family member 7; Belongs to the pancreatic ribonuclease family. (156 aa)
N4BP2NEDD4 binding protein 2. (1770 aa)
RNASE2Ribonuclease A family member 2; Belongs to the pancreatic ribonuclease family. (161 aa)
RNASE4Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (147 aa)
RNASE12Ribonuclease A family member 12 (inactive); Belongs to the pancreatic ribonuclease family. (147 aa)
TSNTranslin. (228 aa)
EXOGExo/endonuclease G. (368 aa)
ANGAngiogenin; Belongs to the pancreatic ribonuclease family. (147 aa)
ERI1Exoribonuclease 1. (345 aa)
MRPL44Mitochondrial ribosomal protein L44. (332 aa)
TATDN1TatD DNase domain containing 1. (333 aa)
MEIOBUncharacterized protein. (344 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (557 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (889 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
PIWIL3Piwi like RNA-mediated gene silencing 3; Belongs to the argonaute family. (887 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (915 aa)
DCPSDecapping enzyme, scavenger. (337 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
RNASET2Uncharacterized protein. (294 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (949 aa)
NUDT16Nudix hydrolase 16. (227 aa)
PARNPoly(A)-specific ribonuclease. (639 aa)
ENSPPAP00000016729Ribosomal_S3_C domain-containing protein. (100 aa)
ENSPPAP00000016638Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (612 aa)
DCLRE1BDNA cross-link repair 1B. (532 aa)
ANGEL2Angel homolog 2. (544 aa)
DBR1Debranching RNA lariats 1. (545 aa)
DNASE2BDeoxyribonuclease 2 beta. (361 aa)
ISG20L2Interferon stimulated exonuclease gene 20 like 2. (352 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa)
TSEN15tRNA splicing endonuclease subunit 15. (175 aa)
YBEYYbeY metalloendoribonuclease. (167 aa)
ENSPPAP00000015279Sen15 domain-containing protein. (142 aa)
TSNAXTranslin associated factor X. (290 aa)
APTXAprataxin. (354 aa)
CNOT6LCCR4-NOT transcription complex subunit 6 like. (548 aa)
POLD1DNA polymerase. (1133 aa)
PLD6Phospholipase D family member 6. (252 aa)
EXOSC3Exosome component 3. (275 aa)
RIDAReactive intermediate imine deaminase A homolog. (137 aa)
RNASELRibonuclease L. (741 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1078 aa)
TATDN2Uncharacterized protein. (761 aa)
TDP1Tyrosyl-DNA phosphodiesterase 1. (608 aa)
ANGEL1Angel homolog 1. (668 aa)
OGG1ENDO3c domain-containing protein. (345 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
TDP2Tyrosyl-DNA phosphodiesterase 2. (362 aa)
MGME1Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (344 aa)
FANCMFA complementation group M. (2048 aa)
ISG20Interferon stimulated exonuclease gene 20. (179 aa)
NYNRINNYN domain and retroviral integrase containing. (1898 aa)
PGBD5PiggyBac transposable element derived 5. (455 aa)
RAD1RAD1 checkpoint DNA exonuclease. (282 aa)
ERI2ERI1 exoribonuclease family member 2. (660 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (908 aa)
ENSPPAP00000009956Uncharacterized protein. (245 aa)
RNASEH2ARibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (299 aa)
ASTE1Asteroid homolog 1. (704 aa)
REXO4REX4 homolog, 3'-5' exonuclease. (422 aa)
G3BP1G3BP stress granule assembly factor 1. (466 aa)
DDX1DEAD-box helicase 1. (740 aa)
ENSPPAP00000007423Uncharacterized protein. (232 aa)
PNLDC1PARN like, ribonuclease domain containing 1. (531 aa)
SLFN12LSchlafen family member 12 like. (617 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RBBP8RB binding protein 8, endonuclease. (895 aa)
TTC38Tetratricopeptide repeat domain 38. (469 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (706 aa)
MUS81MUS81 structure-specific endonuclease subunit. (551 aa)
EXOSC5Exosome component 5. (235 aa)
RPP40Ribonuclease P/MRP subunit p40. (363 aa)
TRIRTelomerase RNA component interacting RNase. (172 aa)
TREX1Three prime repair exonuclease 1. (369 aa)
RNASE8Ribonuclease A family member 8; Belongs to the pancreatic ribonuclease family. (155 aa)
SWT1SWT1 RNA endoribonuclease homolog. (900 aa)
ENSPPAP00000004806Uncharacterized protein. (142 aa)
DIS3LDIS3 like exosome 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (1058 aa)
RNASE11Ribonuclease A family member 11 (inactive); Belongs to the pancreatic ribonuclease family. (199 aa)
ERVMER34-1Endogenous retrovirus group MER34 member 1, envelope. (563 aa)
PLD3Phospholipase D family member 3. (490 aa)
PIWIL1Piwi like RNA-mediated gene silencing 1; Belongs to the argonaute family. (861 aa)
POP1POP1 homolog, ribonuclease P/MRP subunit. (1023 aa)
POP7Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family. (140 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (771 aa)
LACTB2Lactamase beta 2. (287 aa)
DNASE1L1Deoxyribonuclease; Belongs to the DNase I family. (302 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
ELAC2ElaC ribonuclease Z 2. (826 aa)
DFFBDNA fragmentation factor subunit beta. (362 aa)
XRN15'-3' exoribonuclease 1. (1706 aa)
RPP25Ribonuclease P and MRP subunit p25. (199 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
SLFN12Schlafen family member 12. (579 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (429 aa)
RNASE1Ribonuclease A family member 1, pancreatic; Belongs to the pancreatic ribonuclease family. (156 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3. (875 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa)
LOC100978496RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (390 aa)
ZGRF1Zinc finger GRF-type containing 1. (2103 aa)
ENSPPAP00000000720Uncharacterized protein. (96 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1198 aa)
EXOSC9Exosome component 9. (456 aa)
RPP30Ribonuclease P/MRP subunit p30. (318 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (955 aa)
POP5Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (163 aa)
DCLRE1ADNA cross-link repair 1A. (1040 aa)
CNOT8CCR4-NOT transcription complex subunit 8. (292 aa)
EXOSC7Exosome component 7. (291 aa)
TSEN54tRNA splicing endonuclease subunit 54. (496 aa)
TOE1Target of EGR1, exonuclease. (523 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (1419 aa)
EME1Essential meiotic structure-specific endonuclease 1. (571 aa)
POLGDNA polymerase gamma, catalytic subunit. (1234 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa)
NOCTNocturnin. (394 aa)
ERI3ERI1 exoribonuclease family member 3. (337 aa)
DNASE1L3Deoxyribonuclease; Belongs to the DNase I family. (305 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (684 aa)
EXD3Exonuclease 3'-5' domain containing 3. (878 aa)
FEN1-2Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (308 aa)
EXD2Exonuclease 3'-5' domain containing 2. (621 aa)
DCLRE1CDNA cross-link repair 1C. (590 aa)
ARID3AUncharacterized protein. (373 aa)
USB1U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the 2H phosphoesterase superfamily. USB1 family. (265 aa)
DCP2Decapping mRNA 2. (417 aa)
EQTNEquatorin. (294 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1017 aa)
ZC3H12CZinc finger CCCH-type containing 12C. (884 aa)
PLD4Phospholipase D family member 4. (515 aa)
DIS3DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa)
RPP38Ribonuclease P/MRP subunit p38. (311 aa)
C12orf10Chromosome 12 open reading frame 10. (376 aa)
ZC3H12DZinc finger CCCH-type containing 12D. (526 aa)
DXODecapping exoribonuclease. (396 aa)
ENDOGEndonuclease. (188 aa)
RPP14Ribonuclease P/MRP subunit p14. (124 aa)
MARF1Meiosis regulator and mRNA stability factor 1. (1742 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
ENSPPAP00000036339Uncharacterized protein. (244 aa)
PRORPPRORP domain-containing protein. (583 aa)
BIVMBIVM-ERCC5 readthrough. (1640 aa)
N4BP2L1NEDD4 binding protein 2 like 1. (244 aa)
ENSPPAP00000035415Uncharacterized protein. (689 aa)
POP4Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (220 aa)
ENSPPAP00000034890Uncharacterized protein. (126 aa)
NOB1RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (412 aa)
ENSPPAP00000034340NTF2 domain-containing protein. (394 aa)
SETMARSET domain and mariner transposase fusion gene. (684 aa)
REXO2RNA exonuclease 2. (237 aa)
AENApoptosis enhancing nuclease. (325 aa)
ENSPPAP00000033446KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (253 aa)
ZC3H12BZinc finger CCCH-type containing 12B. (836 aa)
RNASEKRibonuclease K. (137 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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