74 items (Pan paniscus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SLC2A4	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	DNM2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (785 aa)
	LOC100978544	Uncharacterized protein. (893 aa)
	APP	Amyloid beta precursor protein. (770 aa)
	ACKR3	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	FNBP1	Formin binding protein 1. (621 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1012 aa)
	TFRC	Transferrin receptor. (773 aa)
	ENSPPAP00000005201	Clat_adaptor_s domain-containing protein. (54 aa)
	OCRL	OCRL inositol polyphosphate-5-phosphatase. (887 aa)
	NUMB	NUMB endocytic adaptor protein. (651 aa)
	SPHK1	Sphingosine kinase 1. (470 aa)
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
	SYNJ1	Synaptojanin 1. (1614 aa)
	FCHO2	FCH domain only 2. (780 aa)
	LDLR	Low density lipoprotein receptor. (849 aa)
	RAB35	Uncharacterized protein. (348 aa)
	CLTB	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (180 aa)
	CLHC1	Clathrin heavy chain linker domain-containing protein 1. (586 aa)
	INPP5F	Inositol polyphosphate-5-phosphatase F. (1133 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
	DAB2	DAB adaptor protein 2. (752 aa)
	VLDLR	Very low density lipoprotein receptor. (1038 aa)
	LRP10	LDL receptor related protein 10. (715 aa)
	LRP1	LDL receptor related protein 1. (4544 aa)
	LOC100979625	Uncharacterized protein. (545 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (943 aa)
	CLTCL1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1639 aa)
	ATAT1	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (423 aa)
	TF	Transferrin; Belongs to the transferrin family. (698 aa)
	AP2B1	AP complex subunit beta. (951 aa)
	AP1S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
	SLC18A3	Solute carrier family 18 member A3. (532 aa)
	ITSN2	Intersectin 2. (1693 aa)
	CUBN	Cubilin. (3623 aa)
	CDHR5	Cadherin related family member 5. (758 aa)
	AMN	Amnion associated transmembrane protein. (385 aa)
	EPS15	Epidermal growth factor receptor pathway substrate 15. (885 aa)
	SORT1	Sortilin. (569 aa)
	AP2M1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (459 aa)
	PICALM	Phosphatidylinositol binding clathrin assembly protein. (673 aa)
	LRP3	LDL receptor related protein 3. (774 aa)
	ENSPPAP00000028117	Uncharacterized protein. (86 aa)
	SNAP91	Synaptosome associated protein 91. (907 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
	RAMP2	Receptor activity modifying protein 2. (175 aa)
	REPS1	RALBP1 associated Eps domain containing 1. (780 aa)
	MYO6	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1261 aa)
	HSPD1	Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (598 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1056 aa)
	ARRB2	Arrestin beta 2. (447 aa)
	EPN1	Epsin 1. (642 aa)
	LRP12	LDL receptor related protein 12. (845 aa)
	DNM1L	Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (236 aa)
	ENSPPAP00000035589	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (88 aa)
	AAK1	AP2 associated kinase 1. (962 aa)
	AP1S3	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (163 aa)
	ITSN1	Intersectin 1. (1720 aa)
	FCHO1	FCH domain only 1. (825 aa)
	SELE	Selectin E. (612 aa)
	ARRB1	Arrestin beta 1. (415 aa)
	EPN3	Epsin 3. (630 aa)
	CTTN	SH3 domain-containing protein. (550 aa)
	SGIP1	SH3 domain GRB2 like endophilin interacting protein 1. (859 aa)
	LRP2	LDL receptor related protein 2. (4641 aa)
	FCHSD2	Uncharacterized protein. (591 aa)
	AP1S2	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
	NECAP2	NECAP endocytosis associated 2. (273 aa)
	NECAP1	NECAP endocytosis associated 1. (280 aa)
	LOC100975678	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (566 aa)
	EPS15L1	Epidermal growth factor receptor pathway substrate 15 like 1. (910 aa)
	SH3BP4	SH3 domain binding protein 4. (963 aa)
	DGKD	Diacylglycerol kinase. (1254 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAK1	AP2A1	ENSPPAP00000035682	ENSPPAP00000006639	AP2 associated kinase 1.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.630
AAK1	AP2B1	ENSPPAP00000035682	ENSPPAP00000016344	AP2 associated kinase 1.	AP complex subunit beta.	0.881
AAK1	AP2M1	ENSPPAP00000035682	ENSPPAP00000025105	AP2 associated kinase 1.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.933
AAK1	CLHC1	ENSPPAP00000035682	ENSPPAP00000009117	AP2 associated kinase 1.	Clathrin heavy chain linker domain-containing protein 1.	0.489
AAK1	CLTA	ENSPPAP00000035682	ENSPPAP00000035226	AP2 associated kinase 1.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.444
AAK1	CLTB	ENSPPAP00000035682	ENSPPAP00000008764	AP2 associated kinase 1.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.503
AAK1	CLTC	ENSPPAP00000035682	ENSPPAP00000011246	AP2 associated kinase 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.526
AAK1	CLTCL1	ENSPPAP00000035682	ENSPPAP00000014841	AP2 associated kinase 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.526
AAK1	DAB2	ENSPPAP00000035682	ENSPPAP00000011373	AP2 associated kinase 1.	DAB adaptor protein 2.	0.431
AAK1	ENSPPAP00000005201	ENSPPAP00000035682	ENSPPAP00000005201	AP2 associated kinase 1.	Clat_adaptor_s domain-containing protein.	0.900
AAK1	ENSPPAP00000035589	ENSPPAP00000035682	ENSPPAP00000035589	AP2 associated kinase 1.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.444
AAK1	EPN1	ENSPPAP00000035682	ENSPPAP00000033865	AP2 associated kinase 1.	Epsin 1.	0.452
AAK1	EPS15	ENSPPAP00000035682	ENSPPAP00000019816	AP2 associated kinase 1.	Epidermal growth factor receptor pathway substrate 15.	0.942
AAK1	EPS15L1	ENSPPAP00000035682	ENSPPAP00000042144	AP2 associated kinase 1.	Epidermal growth factor receptor pathway substrate 15 like 1.	0.722
AAK1	FCHO1	ENSPPAP00000035682	ENSPPAP00000036102	AP2 associated kinase 1.	FCH domain only 1.	0.497
AAK1	FCHO2	ENSPPAP00000035682	ENSPPAP00000007737	AP2 associated kinase 1.	FCH domain only 2.	0.479
AAK1	HIP1R	ENSPPAP00000035682	ENSPPAP00000032578	AP2 associated kinase 1.	Huntingtin interacting protein 1 related.	0.620
AAK1	ITSN1	ENSPPAP00000035682	ENSPPAP00000035901	AP2 associated kinase 1.	Intersectin 1.	0.472
AAK1	ITSN2	ENSPPAP00000035682	ENSPPAP00000018222	AP2 associated kinase 1.	Intersectin 2.	0.627
AAK1	LOC100978544	ENSPPAP00000035682	ENSPPAP00000001769	AP2 associated kinase 1.	Uncharacterized protein.	0.835