Your Input: | |
| | RFC5 | Replication factor C subunit 5. (354 aa) |
| | PRIM2 | Uncharacterized protein. (158 aa) |
| | NT5M | Uncharacterized protein. (161 aa) |
| | NFIA | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (505 aa) |
| | ZGRF1 | Zinc finger GRF-type containing 1. (2103 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3417 aa) |
| | DNAJA3 | DnaJ heat shock protein family (Hsp40) member A3. (480 aa) |
| | SRPK2 | SRSF protein kinase 2. (687 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | CHTF8 | Chromosome transmission fidelity factor 8. (121 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | ENSPPAP00000001955 | Uncharacterized protein. (170 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) |
| | SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (521 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | ING5 | Inhibitor of growth family member 5. (254 aa) |
| | ENSPPAP00000003540 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa) |
| | BOD1L1 | Biorientation of chromosomes in cell division 1 like 1. (2968 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | ZNF830 | Zinc finger protein 830. (392 aa) |
| | GMNC | Geminin coiled-coil domain containing. (342 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (435 aa) |
| | ENSPPAP00000004264 | CAF1C_H4-bd domain-containing protein. (92 aa) |
| | ENSPPAP00000004355 | Uncharacterized protein. (507 aa) |
| | STRA8 | Stimulated by retinoic acid 8. (330 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | ENSPPAP00000004814 | RPA_C domain-containing protein. (241 aa) |
| | LOC100988174 | WD_REPEATS_REGION domain-containing protein. (446 aa) |
| | CHEK1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (476 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | HELB | DNA helicase B. (1087 aa) |
| | DBF4 | DBF4 zinc finger. (655 aa) |
| | ENSPPAP00000005322 | CAF1C_H4-bd domain-containing protein. (55 aa) |
| | PCLAF | PAF domain-containing protein. (115 aa) |
| | TREX1 | Three prime repair exonuclease 1. (369 aa) |
| | RBBP6 | RB binding protein 6, ubiquitin ligase. (1766 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1473 aa) |
| | TTC38 | Tetratricopeptide repeat domain 38. (469 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (895 aa) |
| | CINP | Cyclin dependent kinase 2 interacting protein. (227 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | POLK | DNA polymerase kappa. (897 aa) |
| | RTF2 | Replication termination factor 2. (336 aa) |
| | ENSPPAP00000007509 | Helicase C-terminal domain-containing protein. (317 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (596 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1252 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1143 aa) |
| | POLQ | DNA polymerase theta. (2731 aa) |
| | GRWD1 | WD_REPEATS_REGION domain-containing protein. (446 aa) |
| | ENSPPAP00000008914 | Uncharacterized protein. (164 aa) |
| | NFIX | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (495 aa) |
| | RNASEH2A | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (299 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (1047 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (876 aa) |
| | LRWD1 | Leucine rich repeats and WD repeat domain containing 1. (647 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (908 aa) |
| | LOC103784398 | Uncharacterized protein. (381 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (840 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (774 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | CDC45 | Cell division cycle 45. (598 aa) |
| | FANCM | FA complementation group M. (2048 aa) |
| | MGME1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (344 aa) |
| | ENSPPAP00000011671 | WD_REPEATS_REGION domain-containing protein. (395 aa) |
| | ENSPPAP00000012006 | Uncharacterized protein. (319 aa) |
| | FAM111A | Family with sequence similarity 111 member A. (594 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (1078 aa) |
| | CENPX | Centromere protein X. (131 aa) |
| | DUT | Deoxyuridine triphosphatase. (252 aa) |
| | ENSPPAP00000013353 | Uncharacterized protein. (117 aa) |
| | CHAF1B | Chromatin assembly factor 1 subunit B. (559 aa) |
| | TBRG1 | Transforming growth factor beta regulator 1. (411 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) |
| | RRM2B | Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (350 aa) |
| | DTD1 | D-aminoacyl-tRNA deacylase. (223 aa) |
| | REPIN1 | Replication initiator 1. (593 aa) |
| | NFIB | CTF/NF-I domain-containing protein. (202 aa) |
| | POLD1 | DNA polymerase. (1133 aa) |
| | ORC2 | Origin recognition complex subunit 2. (577 aa) |
| | DHX9 | DExH-box helicase 9. (1270 aa) |
| | ENSPPAP00000019064 | Protein kinase domain-containing protein. (201 aa) |
| | ENSPPAP00000019077 | Uncharacterized protein. (54 aa) |
| | DONSON | Downstream neighbor of SON. (551 aa) |
| | NASP | Nuclear autoantigenic sperm protein. (637 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | TM4SF19 | Uncharacterized protein. (299 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | THOC1 | THO complex 1. (660 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (869 aa) |
| | ENSPPAP00000016638 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (612 aa) |
| | RPAIN | RPA interacting protein. (231 aa) |
| | ENSPPAP00000016404 | Uncharacterized protein. (397 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1273 aa) |
| | NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa) |
| | CDK2AP1 | Uncharacterized protein. (133 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1251 aa) |
| | HMGA1 | Uncharacterized protein. (201 aa) |
| | FAM111B | Family with sequence similarity 111 member B. (733 aa) |
| | E4F1 | E4F transcription factor 1. (785 aa) |
| | RMI2 | RecQ mediated genome instability 2. (126 aa) |
| | DTL | Denticleless E3 ubiquitin protein ligase homolog. (701 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (116 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1832 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (635 aa) |
| | ENSPPAP00000014328 | BRCT domain-containing protein. (581 aa) |
| | CHAF1A | Chromatin assembly factor 1 subunit A. (938 aa) |
| | POLI | DNA polymerase iota. (660 aa) |
| | POLG2 | DNA polymerase gamma 2, accessory subunit. (485 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (301 aa) |
| | RTEL1-2 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1103 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | PTMS | Parathymosin. (89 aa) |
| | ENSPPAP00000021369 | Helicase C-terminal domain-containing protein. (339 aa) |
| | WDR18 | WD repeat domain 18. (413 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa) |
| | LIG3 | DNA ligase. (1008 aa) |
| | RNASEH1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (286 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1383 aa) |
| | WRNIP1 | WRN helicase interacting protein 1. (572 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (998 aa) |
| | TOP1MT | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (584 aa) |
| | BLM | BLM RecQ like helicase. (1417 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | ENSPPAP00000023005 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (285 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3130 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (692 aa) |
| | ETAA1 | ETAA1 activator of ATR kinase. (898 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | TWNK | Twinkle mtDNA helicase. (582 aa) |
| | SSBP1 | Single stranded DNA binding protein 1. (148 aa) |
| | ENSPPAP00000024328 | Protein kinase domain-containing protein. (212 aa) |
| | ING4 | Inhibitor of growth protein. (248 aa) |
| | TIMELESS | Timeless circadian regulator. (1208 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1103 aa) |
| | CDK9 | Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa) |
| | SIRT7 | Sirtuin 7. (353 aa) |
| | ZPR1 | ZPR1 zinc finger. (459 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (470 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (378 aa) |
| | KIN | Kin17 DNA and RNA binding protein. (393 aa) |
| | LOC100995284 | Uncharacterized protein. (346 aa) |
| | ENSPPAP00000026505 | Sld5 domain-containing protein. (168 aa) |
| | ENSPPAP00000026647 | RRM domain-containing protein. (257 aa) |
| | TRAIP | TRAF interacting protein. (469 aa) |
| | ENSPPAP00000026865 | Uncharacterized protein. (381 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (859 aa) |
| | NFIC | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (530 aa) |
| | RBBP7 | RB binding protein 7, chromatin remodeling factor. (469 aa) |
| | DDX21 | DExD-box helicase 21. (783 aa) |
| | ENSPPAP00000027311 | Uncharacterized protein. (720 aa) |
| | ENSPPAP00000027404 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (246 aa) |
| | WRN | WRN RecQ like helicase. (1405 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | ORC3 | Origin recognition complex subunit 3. (712 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1060 aa) |
| | OOEP | Oocyte expressed protein. (149 aa) |
| | SDE2 | SDE2 telomere maintenance homolog. (451 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | DDX23 | DEAD-box helicase 23. (820 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1318 aa) |
| | RBM48 | RNA binding motif protein 48. (377 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (597 aa) |
| | CORT | Somatostatin domain-containing protein. (143 aa) |
| | ENSPPAP00000030284 | Uncharacterized protein. (395 aa) |
| | POLH | DNA polymerase eta. (712 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa) |
| | SAMHD1 | SAM domain and HD domain-containing protein 1. (626 aa) |
| | PRIMPOL | Uncharacterized protein. (431 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa) |
| | RECQL4 | RecQ like helicase 4. (1208 aa) |
| | ENSPPAP00000031761 | Uncharacterized protein; Belongs to the DEAD box helicase family. (720 aa) |
| | ENSPPAP00000031824 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (341 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | GINS1 | GINS complex subunit 1. (196 aa) |
| | SLFN11 | Schlafen family member 11. (888 aa) |
| | SSRP1 | Structure specific recognition protein 1. (843 aa) |
| | CCDC88A | Coiled-coil domain containing 88A. (1824 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (437 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | SETMAR | SET domain and mariner transposase fusion gene. (684 aa) |
| | GMNN | Geminin DNA replication inhibitor. (209 aa) |
| | RRM2 | Ribonucleotide reductase regulatory subunit M2. (449 aa) |
| | RBBP4 | RB binding protein 4, chromatin remodeling factor. (425 aa) |
| | RBMS1 | Uncharacterized protein. (401 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) |
| | ENSPPAP00000035310 | Uncharacterized protein. (121 aa) |
| | RFC2 | Replication factor C subunit 2. (320 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | ENSPPAP00000035875 | WD_REPEATS_REGION domain-containing protein. (427 aa) |
| | DDX50 | DExD-box helicase 50. (737 aa) |
| | NRM | Nurim. (262 aa) |
| | TICRR | TOPBP1 interacting checkpoint and replication regulator. (1911 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa) |
| | MCMBP | Minichromosome maintenance complex binding protein. (641 aa) |
| | ENSPPAP00000037860 | Uncharacterized protein. (852 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | RFC1 | Replication factor C subunit 1. (1148 aa) |
| | ENSPPAP00000039065 | Uncharacterized protein. (350 aa) |
| | POLD3 | Uncharacterized protein. (459 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (155 aa) |
| | FEN1-2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (308 aa) |
| | PURA | Purine rich element binding protein A. (288 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (954 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (146 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2614 aa) |
| | POLN | DNA polymerase nu. (900 aa) |
| | DNAJC2 | DnaJ heat shock protein family (Hsp40) member C2. (620 aa) |
| | POLA1 | DNA polymerase. (1468 aa) |
| | POLG | DNA polymerase gamma, catalytic subunit. (1234 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (777 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (571 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (765 aa) |
| | NAP1L1 | Nucleosome assembly protein 1 like 1; Belongs to the nucleosome assembly protein (NAP) family. (395 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1833 aa) |
| | LIG1 | DNA ligase. (919 aa) |
| | NOC3L | Nucleolar complex protein 3 homolog. (800 aa) |
| | CDC34 | Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. (233 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | KHDC3L | KH domain containing 3 like, subcortical maternal complex member. (217 aa) |
| | ATRX | ATRX chromatin remodeler. (2492 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1096 aa) |
| | FBH1 | F-box DNA helicase 1. (1096 aa) |
