STRINGSTRING
DDB2 DDB2 BRCA2 BRCA2 NTHL1 NTHL1 ATXN3 ATXN3 ERCC6 ERCC6 PNKP PNKP RAD23A RAD23A ENSPPAP00000004814 ENSPPAP00000004814 RPA2 RPA2 HUS1B HUS1B RNF111 RNF111 POLK POLK SIRT1 SIRT1 TP53 TP53 OGG1 OGG1 ERCC8 ERCC8 ENSPPAP00000012418 ENSPPAP00000012418 GTF2H1 GTF2H1 ENSPPAP00000013353 ENSPPAP00000013353 POLD1 POLD1 ENSPPAP00000018389 ENSPPAP00000018389 ENSPPAP00000018781 ENSPPAP00000018781 HUS1 HUS1 LIG4 LIG4 CETN1 CETN1 POLR2I POLR2I MNAT1 MNAT1 POLE POLE USP45 USP45 DDB1 DDB1 ERCC4 ERCC4 ERCC3 ERCC3 SLC30A9 SLC30A9 GTF2H2 GTF2H2 USP7 USP7 POLL POLL BRIP1 BRIP1 FANCC FANCC RPA3 RPA3 CETN2 CETN2 UVSSA UVSSA RPA1 RPA1 GTF2H4 GTF2H4 GTF2H3 GTF2H3 XPA XPA ENSPPAP00000035310 ENSPPAP00000035310 BIVM BIVM RAD23B RAD23B FAN1 FAN1 KAT5 KAT5 POLD3 POLD3 ENSPPAP00000039593 ENSPPAP00000039593 GTF2H5 GTF2H5 XAB2 XAB2 XPC XPC SLX4 SLX4 ERCC1 ERCC1 COMMD1 COMMD1 ERCC2 ERCC2 MMS19 MMS19
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDB2Damage specific DNA binding protein 2. (427 aa)
BRCA2BRCA2 DNA repair associated. (3417 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa)
ATXN3Josephin domain-containing protein. (312 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1491 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (363 aa)
ENSPPAP00000004814RPA_C domain-containing protein. (241 aa)
RPA2Replication protein A2. (270 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (278 aa)
RNF111Ring finger protein 111. (993 aa)
POLKDNA polymerase kappa. (897 aa)
SIRT1Sirtuin 1. (693 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
OGG1ENDO3c domain-containing protein. (345 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
ENSPPAP00000012418Uncharacterized protein. (412 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
ENSPPAP00000013353Uncharacterized protein. (117 aa)
POLD1DNA polymerase. (1133 aa)
ENSPPAP00000018389Uncharacterized protein. (112 aa)
ENSPPAP00000018781Uncharacterized protein. (136 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (259 aa)
LIG4DNA ligase. (911 aa)
CETN1Centrin 1. (172 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa)
USP45Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (814 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
SLC30A9Solute carrier family 30 member 9. (567 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1109 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1249 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (543 aa)
RPA3Replication protein A3. (121 aa)
CETN2Centrin 2. (172 aa)
UVSSAUV stimulated scaffold protein A. (709 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
GTF2H3General transcription factor IIH subunit 3. (308 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
ENSPPAP00000035310Uncharacterized protein. (121 aa)
BIVMBIVM-ERCC5 readthrough. (1640 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (409 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1017 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
POLD3Uncharacterized protein. (459 aa)
ENSPPAP00000039593Uncharacterized protein. (103 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
XAB2XPA binding protein 2. (855 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (946 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1833 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
COMMD1Copper metabolism domain containing 1. (190 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1030 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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