44 items (Pan paniscus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HELQ	Helicase, POLQ like. (1101 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	ERCC6	ERCC excision repair 6, chromatin remodeling factor. (1491 aa)
	PNKP	Polynucleotide kinase 3'-phosphatase. (521 aa)
	POLQ	DNA polymerase theta. (2731 aa)
	UVRAG	UV radiation resistance associated. (698 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	ENSPPAP00000011953	Ku domain-containing protein. (586 aa)
	ERCC8	ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
	PRPF19	Pre-mRNA processing factor 19. (509 aa)
	HMCES	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (354 aa)
	MLH1	MutL homolog 1. (756 aa)
	DCLRE1B	DNA cross-link repair 1B. (532 aa)
	IFFO2	IF rod domain-containing protein; Belongs to the intermediate filament family. (343 aa)
	PSMD14	Proteasome 26S subunit, non-ATPase 14. (310 aa)
	XRCC5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
	RNF8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (485 aa)
	LIG4	DNA ligase. (911 aa)
	PAXX	PAXX non-homologous end joining factor. (204 aa)
	APLF	Aprataxin and PNKP like factor. (511 aa)
	LIG3	DNA ligase. (1008 aa)
	ENSPPAP00000022942	Ku domain-containing protein. (338 aa)
	MRE11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (692 aa)
	ATP23	Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (246 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
	POLL	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
	XRCC6	X-ray repair cross complementing 6. (547 aa)
	IFFO1	Intermediate filament family orphan 1; Belongs to the intermediate filament family. (571 aa)
	POLM	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa)
	KDM2A	Lysine demethylase 2A. (1162 aa)
	SETMAR	SET domain and mariner transposase fusion gene. (684 aa)
	TP53BP1	Tumor protein p53 binding protein 1. (1977 aa)
	XRCC4	X-ray repair cross complementing 4. (334 aa)
	DNTT	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (509 aa)
	ZBTB7A	Uncharacterized protein. (509 aa)
	CYREN	Uncharacterized protein. (102 aa)
	DCLRE1C	DNA cross-link repair 1C. (590 aa)
	SMARCAL1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (954 aa)
	NHEJ1	Non-homologous end joining factor 1. (299 aa)
	POLA1	DNA polymerase. (1468 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
	DCLRE1A	DNA cross-link repair 1A. (1040 aa)
	ENSPPAP00000042766	SAP domain-containing protein. (225 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLF	ENSPPAP00000011953	ENSPPAP00000020931	ENSPPAP00000011953	Aprataxin and PNKP like factor.	Ku domain-containing protein.	0.710
APLF	ENSPPAP00000022942	ENSPPAP00000020931	ENSPPAP00000022942	Aprataxin and PNKP like factor.	Ku domain-containing protein.	0.710
APLF	ENSPPAP00000042766	ENSPPAP00000020931	ENSPPAP00000042766	Aprataxin and PNKP like factor.	SAP domain-containing protein.	0.647
APLF	LIG3	ENSPPAP00000020931	ENSPPAP00000021778	Aprataxin and PNKP like factor.	DNA ligase.	0.905
APLF	LIG4	ENSPPAP00000020931	ENSPPAP00000019573	Aprataxin and PNKP like factor.	DNA ligase.	0.898
APLF	NHEJ1	ENSPPAP00000020931	ENSPPAP00000040379	Aprataxin and PNKP like factor.	Non-homologous end joining factor 1.	0.686
APLF	PAXX	ENSPPAP00000020931	ENSPPAP00000020280	Aprataxin and PNKP like factor.	PAXX non-homologous end joining factor.	0.764
APLF	PNKP	ENSPPAP00000020931	ENSPPAP00000002910	Aprataxin and PNKP like factor.	Polynucleotide kinase 3'-phosphatase.	0.670
APLF	POLB	ENSPPAP00000020931	ENSPPAP00000001754	Aprataxin and PNKP like factor.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.861
APLF	POLL	ENSPPAP00000020931	ENSPPAP00000027872	Aprataxin and PNKP like factor.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.608
APLF	POLM	ENSPPAP00000020931	ENSPPAP00000029301	Aprataxin and PNKP like factor.	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	0.523
APLF	PRKDC	ENSPPAP00000020931	ENSPPAP00000013799	Aprataxin and PNKP like factor.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.538
APLF	XRCC5	ENSPPAP00000020931	ENSPPAP00000018754	Aprataxin and PNKP like factor.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.989
APLF	XRCC6	ENSPPAP00000020931	ENSPPAP00000028250	Aprataxin and PNKP like factor.	X-ray repair cross complementing 6.	0.969
ATM	DCLRE1A	ENSPPAP00000009058	ENSPPAP00000042205	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA cross-link repair 1A.	0.587
ATM	DCLRE1B	ENSPPAP00000009058	ENSPPAP00000016308	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA cross-link repair 1B.	0.672
ATM	DCLRE1C	ENSPPAP00000009058	ENSPPAP00000038989	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA cross-link repair 1C.	0.792
ATM	ENSPPAP00000011953	ENSPPAP00000009058	ENSPPAP00000011953	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ku domain-containing protein.	0.721
ATM	ENSPPAP00000022942	ENSPPAP00000009058	ENSPPAP00000022942	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ku domain-containing protein.	0.721
ATM	ENSPPAP00000042766	ENSPPAP00000009058	ENSPPAP00000042766	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SAP domain-containing protein.	0.721