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| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1849 aa) |
| | NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa) |
| | MLH1 | MutL homolog 1. (756 aa) |
| | REC8 | REC8 meiotic recombination protein. (547 aa) |
| | RAD54L | RAD54 like. (747 aa) |
| | SYCP1 | Synaptonemal complex protein 1. (976 aa) |
| | RPAIN | RPA interacting protein. (231 aa) |
| | ENSPPAP00000016638 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (612 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (869 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | ENSPPAP00000017476 | Uncharacterized protein. (263 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (570 aa) |
| | ACTL6A | Actin like 6A; Belongs to the actin family. (430 aa) |
| | ENSPPAP00000017700 | Uncharacterized protein. (277 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (915 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) |
| | RAD21L1 | RAD21 cohesin complex component like 1. (556 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | SMC5 | SMC_N domain-containing protein. (1101 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (417 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1088 aa) |
| | AP5S1 | Adaptor related protein complex 5 subunit sigma 1. (200 aa) |
| | NABP1 | Nucleic acid binding protein 1. (204 aa) |
| | SWAP70 | Switching B cell complex subunit SWAP70. (585 aa) |
| | NABP2 | Nucleic acid binding protein 2. (211 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3417 aa) |
| | REC114 | REC114 meiotic recombination protein. (265 aa) |
| | AUNIP | Aurora kinase A and ninein interacting protein. (371 aa) |
| | CCNB1IP1 | Cyclin B1 interacting protein 1. (277 aa) |
| | TM4SF19 | Uncharacterized protein. (299 aa) |
| | ENSPPAP00000018027 | Uncharacterized protein. (238 aa) |
| | BLM | BLM RecQ like helicase. (1417 aa) |
| | THAP9 | THAP domain containing 9. (903 aa) |
| | ENSPPAP00000018238 | Uncharacterized protein. (302 aa) |
| | TPRKB | TP53RK binding protein; Belongs to the CGI121/TPRKB family. (214 aa) |
| | ENSPPAP00000018281 | Uncharacterized protein. (303 aa) |
| | MEIOB | Uncharacterized protein. (344 aa) |
| | MND1 | Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (208 aa) |
| | SWI5 | SWI5 homologous recombination repair protein. (236 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa) |
| | NONO | Non-POU domain containing octamer binding. (471 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (485 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (259 aa) |
| | EPC1 | Enhancer of polycomb homolog. (836 aa) |
| | ENSPPAP00000018916 | Uncharacterized protein. (305 aa) |
| | FANCB | FA complementation group B. (858 aa) |
| | WRN | WRN RecQ like helicase. (1405 aa) |
| | MSH4 | MutS homolog 4. (936 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1249 aa) |
| | NSMCE3 | NSE3 homolog, SMC5-SMC6 complex component. (291 aa) |
| | SWSAP1 | SWIM-type zinc finger 7 associated protein 1. (250 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (547 aa) |
| | SFR1 | SWI5 dependent homologous recombination repair protein 1. (245 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (669 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | HMGB3 | Uncharacterized protein. (207 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1318 aa) |
| | CORT | Somatostatin domain-containing protein. (143 aa) |
| | SYCE3 | Synaptonemal complex central element protein 3. (88 aa) |
| | AICDA | Activation induced cytidine deaminase. (199 aa) |
| | NIPBL | Nipped-B protein. (2804 aa) |
| | SAMHD1 | SAM domain and HD domain-containing protein 1. (626 aa) |
| | SETX | Senataxin. (2669 aa) |
| | RAG2 | Recombination activating 2. (527 aa) |
| | HELQ | Helicase, POLQ like. (1101 aa) |
| | ACTR5 | Actin related protein 5; Belongs to the actin family. (607 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | TEX19 | Testis expressed 19. (164 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | BATF | Basic leucine zipper ATF-like transcription factor. (125 aa) |
| | EXO1 | Exonuclease 1. (846 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (348 aa) |
| | ENSPPAP00000031361 | Uncharacterized protein. (207 aa) |
| | APEX1 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] (318 aa) |
| | RECQL4 | RecQ like helicase 4. (1208 aa) |
| | HSPD1 | Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (598 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa) |
| | TSN | Translin. (228 aa) |
| | ENSPPAP00000033809 | Uncharacterized protein. (73 aa) |
| | TEX11 | Testis expressed 11. (840 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | MSH5 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (839 aa) |
| | ENSPPAP00000034946 | Uncharacterized protein. (276 aa) |
| | CCDC155 | Coiled-coil domain containing 155. (562 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (334 aa) |
| | TCF3 | Transcription factor 3. (673 aa) |
| | ENSPPAP00000035310 | Uncharacterized protein. (121 aa) |
| | RAD51B | RAD51 paralog B. (359 aa) |
| | MCRS1 | Microspherule protein 1. (475 aa) |
| | C19orf57 | Chromosome 19 open reading frame 57. (667 aa) |
| | ENDOG | Endonuclease. (188 aa) |
| | HDAC10 | Histone deacetylase 10. (669 aa) |
| | LOC100975187 | Uncharacterized protein. (446 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1304 aa) |
| | CCDC36 | Coiled-coil domain containing 36. (543 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | CYREN | Uncharacterized protein. (102 aa) |
| | RAD51AP2 | RAD51 associated protein 2. (1158 aa) |
| | TFPT | TCF3 fusion partner. (253 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1017 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) |
| | INO80 | INO80 complex ATPase subunit. (1556 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (590 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (155 aa) |
| | CD40LG | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa) |
| | LOC100987671 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (88 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (299 aa) |
| | POLN | DNA polymerase nu. (900 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (247 aa) |
| | ENSPPAP00000040497 | Uncharacterized protein. (255 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (399 aa) |
| | HROB | Chromosome 17 open reading frame 53. (634 aa) |
| | ENSPPAP00000040700 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (140 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (777 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (571 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (303 aa) |
| | HDGFL2 | HDGF like 2. (646 aa) |
| | LOC100975678 | Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (566 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (238 aa) |
| | INO80E | INO80 complex subunit E. (244 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1833 aa) |
| | SEM1 | Uncharacterized protein. (89 aa) |
| | MLH3 | MutL homolog 3. (1450 aa) |
| | RNF212 | Ring finger protein 212. (296 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1521 aa) |
| | LIG1 | DNA ligase. (919 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (955 aa) |
| | ENSPPAP00000042766 | SAP domain-containing protein. (225 aa) |
| | FBH1 | F-box DNA helicase 1. (1096 aa) |
| | INIP | INTS3 and NABP interacting protein. (104 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1058 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | TEP1 | Telomerase associated protein 1. (2626 aa) |
| | DEF6 | DEF6 guanine nucleotide exchange factor. (621 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | ENSPPAP00000020189 | Uncharacterized protein. (192 aa) |
| | MCMDC2 | Uncharacterized protein. (368 aa) |
| | RTEL1-2 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1103 aa) |
| | C11orf80 | Chromosome 11 open reading frame 80. (572 aa) |
| | MSH3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1113 aa) |
| | ENSPPAP00000021658 | Uncharacterized protein. (339 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | LIG3 | DNA ligase. (1008 aa) |
| | CNTD1 | Cyclin N-terminal domain containing 1. (326 aa) |
| | AP5Z1 | Adaptor related protein complex 5 subunit zeta 1. (807 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | PAXIP1 | PAX interacting protein 1. (1052 aa) |
| | C1orf146 | Chromosome 1 open reading frame 146. (180 aa) |
| | TCF7 | HMG box domain-containing protein. (391 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1383 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (355 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (998 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | SUPV3L1 | Suv3 like RNA helicase. (786 aa) |
| | ENSPPAP00000022942 | Ku domain-containing protein. (338 aa) |
| | INTS3 | Integrator complex subunit 3. (1042 aa) |
| | C14orf39 | Chromosome 14 open reading frame 39. (587 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3130 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (692 aa) |
| | HSF2BP | Heat shock transcription factor 2 binding protein. (334 aa) |
| | ENSPPAP00000023985 | Uncharacterized protein. (183 aa) |
| | KLHDC3 | Kelch domain containing 3. (382 aa) |
| | RAD51C | RAD51 paralog C. (376 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (306 aa) |
| | APEX2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (378 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | CCR6 | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (374 aa) |
| | KIN | Kin17 DNA and RNA binding protein. (393 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (396 aa) |
| | ENSPPAP00000026505 | Sld5 domain-containing protein. (168 aa) |
| | ENSPPAP00000026551 | Uncharacterized protein. (100 aa) |
| | YY1 | Uncharacterized protein. (370 aa) |
| | SHOC1 | Shortage in chiasmata 1. (1444 aa) |
| | ENSPPAP00000004030 | Uncharacterized protein. (272 aa) |
| | INO80D | INO80 complex subunit D. (1027 aa) |
| | MEI4 | Meiotic double-stranded break formation protein 4. (385 aa) |
| | INO80C | INO80 complex subunit C. (228 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | ENSPPAP00000004814 | RPA_C domain-containing protein. (241 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1186 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (313 aa) |
| | TREX1 | Three prime repair exonuclease 1. (369 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (278 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | HFM1 | Helicase for meiosis 1. (1324 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1473 aa) |
| | CDC7 | Cell division cycle 7. (574 aa) |
| | ENSPPAP00000006330 | Uncharacterized protein. (251 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (895 aa) |
| | LOC100973702 | Uncharacterized protein. (201 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (596 aa) |
| | ZFYVE26 | Zinc finger FYVE-type containing 26. (2530 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1252 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1143 aa) |
| | BCL11B | Uncharacterized protein. (459 aa) |
| | DCAF1 | DDB1 and CUL4 associated factor 1. (1507 aa) |
| | FANCD2 | FA complementation group D2. (1259 aa) |
| | MBTD1 | Mbt domain containing 1. (630 aa) |
| | ZSWIM7 | Zinc finger SWIM-type containing 7. (140 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | FOXP3 | Forkhead box P3. (441 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (148 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (908 aa) |
| | KIAA1841 | KIAA1841. (718 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (840 aa) |
| | UBR2 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (774 aa) |
| | PGBD5 | PiggyBac transposable element derived 5. (455 aa) |
| | CDC45 | Cell division cycle 45. (598 aa) |
| | FANCM | FA complementation group M. (2048 aa) |
| | BCL6 | BCL6 transcription repressor. (706 aa) |
| | ENSPPAP00000011953 | Ku domain-containing protein. (586 aa) |
| | PAGR1 | PAXIP1 associated glutamate rich protein 1. (254 aa) |
| | FSBP | Uncharacterized protein. (896 aa) |
| | CENPX | Centromere protein X. (131 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | STAT6 | Signal transducer and activator of transcription. (852 aa) |
| | POGZ | Pogo transposable element derived with ZNF domain. (1410 aa) |
| | ENSPPAP00000013353 | Uncharacterized protein. (117 aa) |
| | EXOSC3 | Exosome component 3. (275 aa) |
| | PSMC3IP | PSMC3 interacting protein. (217 aa) |
| | WDR48 | WD repeat domain 48. (684 aa) |
| | LOC106634832 | Uncharacterized protein. (178 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa) |
| | SFPQ | Splicing factor proline and glutamine rich. (709 aa) |
| | ENSPPAP00000014227 | Uncharacterized protein. (210 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (635 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1832 aa) |
| | RMI2 | RecQ mediated genome instability 2. (126 aa) |
| | TOP2B | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1619 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1299 aa) |
| | RNF212B | Ring finger protein 212B. (300 aa) |
