13 items (Pan paniscus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
	ERCC3	ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
	XPA	XPA, DNA damage recognition and repair factor. (273 aa)
	MFAP4	Microfibril associated protein 4. (280 aa)
	SCARA3	Scavenger receptor class A member 3. (614 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	ENSPPAP00000004900	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (145 aa)
	ENSPPAP00000036267	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (139 aa)
	ERCC2	ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
	GPX1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (200 aa)
	SDF4	Uncharacterized protein. (447 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAT	ENSPPAP00000004900	ENSPPAP00000032648	ENSPPAP00000004900	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.423
CAT	ENSPPAP00000036267	ENSPPAP00000032648	ENSPPAP00000036267	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.423
CAT	GPX1	ENSPPAP00000032648	ENSPPAP00000038253	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.423
ENSPPAP00000004900	CAT	ENSPPAP00000004900	ENSPPAP00000032648	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.423
ENSPPAP00000036267	CAT	ENSPPAP00000036267	ENSPPAP00000032648	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.423
ERCC1	ERCC2	ENSPPAP00000041944	ENSPPAP00000042917	ERCC excision repair 1, endonuclease non-catalytic subunit.	ERCC excision repair 2, TFIIH core complex helicase subunit.	0.945
ERCC1	ERCC3	ENSPPAP00000041944	ENSPPAP00000026079	ERCC excision repair 1, endonuclease non-catalytic subunit.	ERCC excision repair 3, TFIIH core complex helicase subunit.	0.914
ERCC1	ERCC4	ENSPPAP00000041944	ENSPPAP00000025260	ERCC excision repair 1, endonuclease non-catalytic subunit.	ERCC excision repair 4, endonuclease catalytic subunit.	0.999
ERCC1	FEN1	ENSPPAP00000041944	ENSPPAP00000006842	ERCC excision repair 1, endonuclease non-catalytic subunit.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.845
ERCC1	XPA	ENSPPAP00000041944	ENSPPAP00000035261	ERCC excision repair 1, endonuclease non-catalytic subunit.	XPA, DNA damage recognition and repair factor.	0.998
ERCC2	ERCC1	ENSPPAP00000042917	ENSPPAP00000041944	ERCC excision repair 2, TFIIH core complex helicase subunit.	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.945
ERCC2	ERCC3	ENSPPAP00000042917	ENSPPAP00000026079	ERCC excision repair 2, TFIIH core complex helicase subunit.	ERCC excision repair 3, TFIIH core complex helicase subunit.	0.999
ERCC2	ERCC4	ENSPPAP00000042917	ENSPPAP00000025260	ERCC excision repair 2, TFIIH core complex helicase subunit.	ERCC excision repair 4, endonuclease catalytic subunit.	0.927
ERCC2	FEN1	ENSPPAP00000042917	ENSPPAP00000006842	ERCC excision repair 2, TFIIH core complex helicase subunit.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.762
ERCC2	XPA	ENSPPAP00000042917	ENSPPAP00000035261	ERCC excision repair 2, TFIIH core complex helicase subunit.	XPA, DNA damage recognition and repair factor.	0.996
ERCC3	ERCC1	ENSPPAP00000026079	ENSPPAP00000041944	ERCC excision repair 3, TFIIH core complex helicase subunit.	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.914
ERCC3	ERCC2	ENSPPAP00000026079	ENSPPAP00000042917	ERCC excision repair 3, TFIIH core complex helicase subunit.	ERCC excision repair 2, TFIIH core complex helicase subunit.	0.999
ERCC3	ERCC4	ENSPPAP00000026079	ENSPPAP00000025260	ERCC excision repair 3, TFIIH core complex helicase subunit.	ERCC excision repair 4, endonuclease catalytic subunit.	0.908
ERCC3	FEN1	ENSPPAP00000026079	ENSPPAP00000006842	ERCC excision repair 3, TFIIH core complex helicase subunit.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.881
ERCC3	XPA	ENSPPAP00000026079	ENSPPAP00000035261	ERCC excision repair 3, TFIIH core complex helicase subunit.	XPA, DNA damage recognition and repair factor.	0.995