STRINGSTRING
ARC ARC NRP1 NRP1 SOCS5 SOCS5 EGF EGF FAM72A FAM72A SHISA6 SHISA6 NOG NOG IL10 IL10 NPTX1 NPTX1 SOCS4 SOCS4 THAP11 THAP11 CCR2 CCR2 APP APP TAF1 TAF1 ZFYVE28 ZFYVE28 DLGAP2 DLGAP2 IL1RN IL1RN TNF TNF JAK2 JAK2 CRH CRH ADRA2B ADRA2B CACNG2 CACNG2 P2RY1 P2RY1 SLURP2 SLURP2 RASGRF1 RASGRF1 IFNGR2 IFNGR2 AGTR2 AGTR2 NETO1 NETO1 CALCR CALCR FST FST ADH7 ADH7 PATE1 PATE1 CAPN1 CAPN1 ZGPAT ZGPAT ENSPPAP00000010058 ENSPPAP00000010058 DKKL1 DKKL1 CGA CGA FBXW9 FBXW9 HIF1A HIF1A WFIKKN2 WFIKKN2 NLGN3 NLGN3 PPARG PPARG LYPD1 LYPD1 MAPK8IP2 MAPK8IP2 EDN1 EDN1 PINK1 PINK1 NLGN1 NLGN1 CLEC12B CLEC12B PARK7 PARK7 CHMP6 CHMP6 SHC1 SHC1 CDK5R1 CDK5R1 CACNG4 CACNG4 GPRC5A GPRC5A NCF1 NCF1 ESR2 ESR2 HOMER1 HOMER1 PCSK9 PCSK9 HDAC1 HDAC1 CBLB CBLB PPP2R5B PPP2R5B NETO2 NETO2 TAFA1 TAFA1 DLGAP1 DLGAP1 NPTX2 NPTX2 TSG101 TSG101 EPHB2 EPHB2 BTC BTC NCOA3 NCOA3 MTRNR2L4 MTRNR2L4 CCL2 CCL2 HDAC2 HDAC2 HDAC6 HDAC6 PRKCD PRKCD DKK4 DKK4 ENSPPAP00000021246 ENSPPAP00000021246 ERRFI1 ERRFI1 PRRT1 PRRT1 VPS25 VPS25 KLHL24 KLHL24 DKK1 DKK1 RELN RELN ANKRD13C ANKRD13C ENSPPAP00000023305 ENSPPAP00000023305 RWDD1 RWDD1 FBXW7 FBXW7 SERPINE1 SERPINE1 CCL5 CCL5 LRPAP1 LRPAP1 EPGN EPGN RASGRF2 RASGRF2 PXDN PXDN SLC6A9 SLC6A9 LYPD6 LYPD6 LY6H LY6H TGFA TGFA SHISA9 SHISA9 EREG EREG AREG AREG CACNG7 CACNG7 CNIH3 CNIH3 DKK3 DKK3 OPRM1 OPRM1 HFE HFE BEGAIN BEGAIN PDE4D PDE4D NCAPG2 NCAPG2 RAMP3 RAMP3 CAV3 CAV3 SLC24A4 SLC24A4 CBLC CBLC CRHBP CRHBP PATE4 PATE4 RTL8A RTL8A IL36RN IL36RN BICD1 BICD1 BUD31 BUD31 SRC SRC LILRB4 LILRB4 MINK1 MINK1 CACNG5 CACNG5 NRXN1 NRXN1 NLGN2 NLGN2 GSG1 GSG1 LYPD6B LYPD6B HBEGF HBEGF IGSF1 IGSF1 PPARA PPARA MEF2C MEF2C DLGAP3 DLGAP3 ENSPPAP00000032344 ENSPPAP00000032344 TAFA4 TAFA4 FSHB FSHB ITGB1 ITGB1 PSEN1 PSEN1 CNIH2 CNIH2 SHANK1 SHANK1 CBL CBL DKK2 DKK2 ADAM17 ADAM17 LOC100984838 LOC100984838 PTK2B PTK2B ACE2 ACE2 DLGAP4 DLGAP4 DLG4 DLG4 NCK2 NCK2 IL18BP IL18BP CACNG3 CACNG3 SNX6 SNX6 HOMER3 HOMER3 LYNX1 LYNX1 NPTXR NPTXR DAPK1 DAPK1 ADRB2 ADRB2 WFIKKN1 WFIKKN1 CNRIP1 CNRIP1 PLAU PLAU AKAP9 AKAP9 PSCA PSCA GSG1L GSG1L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARCActivity regulated cytoskeleton associated protein. (396 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
FAM72AUncharacterized protein. (149 aa)
SHISA6Shisa family member 6. (461 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
IL10Interleukin 10. (178 aa)
NPTX1Uncharacterized protein. (363 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
THAP11THAP domain containing 11. (309 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
APPAmyloid beta precursor protein. (770 aa)
TAF1Transcription initiation factor TFIID subunit. (1916 aa)
ZFYVE28Zinc finger FYVE-type containing 28. (887 aa)
DLGAP2DLG associated protein 2. (1054 aa)
IL1RNInterleukin-1. (180 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
CRHCorticotropin releasing hormone. (196 aa)
ADRA2BAdrenoceptor alpha 2B. (448 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
SLURP2Secreted LY6/PLAUR domain containing 2. (97 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1270 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
NETO1Neuropilin and tolloid like 1. (533 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (509 aa)
FSTUncharacterized protein. (409 aa)
ADH7Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide. (317 aa)
PATE1Prostate and testis expressed 1. (112 aa)
CAPN1Calpain 1; Belongs to the peptidase C2 family. (733 aa)
ZGPATZinc finger CCCH-type and G-patch domain containing. (531 aa)
ENSPPAP00000010058Uncharacterized protein. (165 aa)
DKKL1Dickkopf like acrosomal protein 1. (242 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (147 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (576 aa)
NLGN3Neuroligin 3. (848 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
LYPD1LY6/PLAUR domain containing 1. (141 aa)
MAPK8IP2Mitogen-activated protein kinase 8 interacting protein 2. (692 aa)
EDN1Endothelin 1. (212 aa)
PINK1PTEN induced kinase 1. (554 aa)
NLGN1Neuroligin 1. (823 aa)
CLEC12BC-type lectin domain family 12 member B. (276 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
CHMP6Uncharacterized protein. (224 aa)
SHC1SHC adaptor protein 1. (584 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (351 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (339 aa)
GPRC5AG protein-coupled receptor class C group 5 member A. (357 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
ESR2Estrogen receptor 2. (530 aa)
HOMER1Homer scaffold protein 1. (358 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (692 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
CBLBCbl proto-oncogene B. (982 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
NETO2Neuropilin and tolloid like 2. (514 aa)
TAFA1Uncharacterized protein. (93 aa)
DLGAP1DLG associated protein 1. (977 aa)
NPTX2Uncharacterized protein. (350 aa)
TSG101Tumor susceptibility 101. (390 aa)
EPHB2EPH receptor B2. (1039 aa)
BTCBetacellulin. (178 aa)
NCOA3Nuclear receptor coactivator. (1423 aa)
MTRNR2L4MT-RNR2 like 4. (28 aa)
CCL2C-C motif chemokine. (99 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (510 aa)
HDAC6Histone deacetylase 6. (1215 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
DKK4Dickkopf WNT signaling pathway inhibitor 4. (224 aa)
ENSPPAP00000021246SOCS box domain-containing protein. (478 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
PRRT1Proline rich transmembrane protein 1. (306 aa)
VPS25Vacuolar protein sorting 25 homolog. (176 aa)
KLHL24Kelch like family member 24. (600 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (289 aa)
RELNReelin. (3460 aa)
ANKRD13CAnkyrin repeat domain 13C. (541 aa)
ENSPPAP00000023305DJ-1_PfpI domain-containing protein. (168 aa)
RWDD1RWD domain containing 1. (243 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (324 aa)
CCL5C-C motif chemokine. (91 aa)
LRPAP1LDL receptor related protein associated protein 1. (357 aa)
EPGNUncharacterized protein. (85 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1237 aa)
PXDNPeroxidasin. (1479 aa)
SLC6A9Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (706 aa)
LYPD6LY6/PLAUR domain containing 6. (171 aa)
LY6HLymphocyte antigen 6 family member H. (166 aa)
TGFATransforming growth factor alpha. (181 aa)
SHISA9Shisa family member 9. (398 aa)
EREGEpiregulin. (169 aa)
AREGEGF-like domain-containing protein. (274 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (245 aa)
CNIH3Cornichon family AMPA receptor auxiliary protein 3. (160 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (350 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (492 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
BEGAINUncharacterized protein. (770 aa)
PDE4DPhosphodiesterase. (706 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (1156 aa)
RAMP3Receptor activity modifying protein 3. (151 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
SLC24A4Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (622 aa)
CBLCUncharacterized protein. (387 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
PATE4Prostate and testis expressed 4. (98 aa)
RTL8ARetrotransposon Gag like 8A. (92 aa)
IL36RNInterleukin-1. (155 aa)
BICD1BICD cargo adaptor 1. (975 aa)
BUD31BUD31 homolog. (144 aa)
SRCTyrosine-protein kinase. (458 aa)
LILRB4Leukocyte immunoglobulin like receptor B4. (408 aa)
MINK1Misshapen like kinase 1. (1333 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
NRXN1Neurexin 1. (1445 aa)
NLGN2COesterase domain-containing protein. (833 aa)
GSG1Germ cell associated 1. (362 aa)
LYPD6BLY6/PLAUR domain containing 6B. (241 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
IGSF1Immunoglobulin superfamily member 1. (1341 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
MEF2CMyocyte enhancer factor 2C. (482 aa)
DLGAP3DLG associated protein 3. (981 aa)
ENSPPAP00000032344Uncharacterized protein. (108 aa)
TAFA4TAFA chemokine like family member 4. (140 aa)
FSHBFollicle stimulating hormone subunit beta. (129 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
CNIH2Cornichon family AMPA receptor auxiliary protein 2. (151 aa)
SHANK1SH3 and multiple ankyrin repeat domains 1. (2007 aa)
CBLCbl proto-oncogene. (906 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
LOC100984838Uncharacterized protein. (334 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
DLGAP4DLG associated protein 4. (992 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
NCK2Cytoplasmic protein. (380 aa)
IL18BPInterleukin 18 binding protein. (194 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
SNX6Sorting nexin; Involved in several stages of intracellular trafficking. (416 aa)
HOMER3Homer scaffold protein 3. (361 aa)
LYNX1Ly6/neurotoxin 1. (116 aa)
NPTXRPentaxin. (169 aa)
DAPK1Death associated protein kinase 1. (1440 aa)
ADRB2Adrenoceptor beta 2. (429 aa)
WFIKKN1Uncharacterized protein. (421 aa)
CNRIP1Cannabinoid receptor interacting protein 1. (164 aa)
PLAUPlasminogen activator, urokinase. (431 aa)
AKAP9A-kinase anchoring protein 9. (3880 aa)
PSCAProstate stem cell antigen. (123 aa)
GSG1LUncharacterized protein. (194 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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