STRINGSTRING
NF1 NF1 FUT1 FUT1 NRP1 NRP1 SYNJ2BP SYNJ2BP EGF EGF CALR CALR EPHA2 EPHA2 SCARB1 SCARB1 ENSPPAP00000002689 ENSPPAP00000002689 GDF2 GDF2 ENSPPAP00000002958 ENSPPAP00000002958 EMC10 EMC10 MEOX2 MEOX2 KLF4 KLF4 BMPR2 BMPR2 TNF TNF NUS1 NUS1 ENSPPAP00000004239 ENSPPAP00000004239 THBS1 THBS1 ENSPPAP00000005251 ENSPPAP00000005251 PTPRM PTPRM FGFBP1 FGFBP1 RHOB RHOB LOC100987247 LOC100987247 EMP2 EMP2 AGTR2 AGTR2 SIRT1 SIRT1 GATA3 GATA3 VEGFA VEGFA ETS1 ETS1 EFNA1 EFNA1 ENSPPAP00000007948 ENSPPAP00000007948 AGT AGT KRIT1 KRIT1 WNT5A WNT5A ADAMTS9 ADAMTS9 GATA2 GATA2 ANGPT4 ANGPT4 DLL4 DLL4 LOC106634197 LOC106634197 HRG HRG JCAD JCAD FBXW9 FBXW9 HIF1A HIF1A AAMP AAMP RHOJ RHOJ BMP4 BMP4 ENSPPAP00000011278 ENSPPAP00000011278 ENSPPAP00000011507 ENSPPAP00000011507 ALOX12 ALOX12 PPARG PPARG STC1 STC1 TSTA3 TSTA3 PDGFB PDGFB SASH1 SASH1 EDN1 EDN1 ATP5F1A ATP5F1A LOC100987645 LOC100987645 HMGB1 HMGB1 WNT7A WNT7A ITGB3 ITGB3 ANXA1 ANXA1 SVBP SVBP BCAS3 BCAS3 TDGF1 TDGF1 MMRN2 MMRN2 CCBE1 CCBE1 ENSPPAP00000016342 ENSPPAP00000016342 NR2F2 NR2F2 FGFR1 FGFR1 BSG BSG TGFB1 TGFB1 PRKCA PRKCA SP1 SP1 PIK3CB PIK3CB ANGPT2 ANGPT2 PLCG1 PLCG1 SERPINF1 SERPINF1 HDAC5 HDAC5 LOC100979570 LOC100979570 RAC1 RAC1 PDCD10 PDCD10 ADGRB1 ADGRB1 TBXA2R TBXA2R BCAR1 BCAR1 PTN PTN PATZ1 PATZ1 GRN GRN LOC100989777 LOC100989777 ANXA3 ANXA3 RRAS RRAS FGF16 FGF16 MECP2 MECP2 CEACAM1 CEACAM1 TEK TEK LOC100982269 LOC100982269 RGCC RGCC FBXW7 FBXW7 CARD10 CARD10 PROX1 PROX1 MAP3K3 MAP3K3 SPRED1 SPRED1 ACVRL1 ACVRL1 PRCP PRCP AKT3 AKT3 PIK3CD PIK3CD DNAJA4 DNAJA4 HMOX1 HMOX1 ABL1 ABL1 ANGPT1 ANGPT1 PRKD1 PRKD1 MAP2K5 MAP2K5 PRKD2 PRKD2 ATP5F1B ATP5F1B RIN2 RIN2 NFE2L2 NFE2L2 HSPB1 HSPB1 SMOC2 SMOC2 AMOT AMOT BMPER BMPER MET MET CXCL13 CXCL13 PTK2B PTK2B ADAM17 ADAM17 VASH1 VASH1 STARD13 STARD13 LGMN LGMN ROCK2 ROCK2 ATOH8 ATOH8 NR2E1 NR2E1 DAB2IP DAB2IP NOS3 NOS3 PIK3C2A PIK3C2A SRPX2 SRPX2 FOXP1 FOXP1 ITGB1BP1 ITGB1BP1 ENSPPAP00000033137 ENSPPAP00000033137 DCN DCN MEF2C MEF2C NOTCH1 NOTCH1 CD40 CD40 GPI GPI PLK2 PLK2 AKT1 AKT1 SPARC SPARC APOH APOH FGF1 FGF1 GPLD1 GPLD1 JUP JUP ZC3H12A ZC3H12A NRP2 NRP2 ATP2B4 ATP2B4 ADGRA2 ADGRA2 BMP10 BMP10 FGF2 FGF2 P2RX4 P2RX4 HDAC7 HDAC7 STAT5A STAT5A GADD45A GADD45A FLT4 FLT4 GLUL GLUL KDR KDR PIK3CG PIK3CG PTGS2 PTGS2 PTK2 PTK2 HDAC9 HDAC9 VEGFC VEGFC CIB1 CIB1 SEMA5A SEMA5A SP100 SP100 PLPP3 PLPP3 PDCD6 PDCD6 SLIT2 SLIT2 SEMA4A SEMA4A FGF18 FGF18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NF1Neurofibromin 1. (2839 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (366 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
CALRCalreticulin. (417 aa)
EPHA2EPH receptor A2. (976 aa)
SCARB1Uncharacterized protein; Belongs to the CD36 family. (498 aa)
ENSPPAP00000002689CFC domain-containing protein. (158 aa)
GDF2Growth differentiation factor 2. (429 aa)
ENSPPAP00000002958Uncharacterized protein. (231 aa)
EMC10Uncharacterized protein. (378 aa)
MEOX2Mesenchyme homeobox 2. (302 aa)
KLF4Kruppel like factor 4. (477 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1012 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
NUS1Uncharacterized protein. (220 aa)
ENSPPAP00000004239Uncharacterized protein. (268 aa)
THBS1Thrombospondin 1. (1173 aa)
ENSPPAP00000005251Uncharacterized protein. (204 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1465 aa)
FGFBP1Fibroblast growth factor binding protein 1. (234 aa)
RHOBRas homolog family member B. (196 aa)
LOC100987247CFC domain-containing protein. (170 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
SIRT1Sirtuin 1. (693 aa)
GATA3GATA binding protein 3. (444 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (372 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
ENSPPAP00000007948Uncharacterized protein. (475 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
KRIT1Uncharacterized protein. (736 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1935 aa)
GATA2GATA binding protein 2. (480 aa)
ANGPT4Angiopoietin 4. (503 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
LOC106634197Uncharacterized protein. (198 aa)
HRGHistidine rich glycoprotein. (525 aa)
JCADJunctional cadherin 5 associated. (1352 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
AAMPAngio associated migratory cell protein. (434 aa)
RHOJRas homolog family member J. (214 aa)
BMP4TGF_BETA_2 domain-containing protein. (402 aa)
ENSPPAP00000011278Protein kinase domain-containing protein. (351 aa)
ENSPPAP00000011507Uncharacterized protein. (290 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
STC1Stanniocalcin 1. (247 aa)
TSTA3Tissue specific transplantation antigen P35B. (321 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SASH1SAM and SH3 domain containing 1. (1251 aa)
EDN1Endothelin 1. (212 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (570 aa)
LOC100987645Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
HMGB1Uncharacterized protein. (215 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (814 aa)
ANXA1Annexin. (346 aa)
SVBPSmall vasohibin binding protein. (66 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
MMRN2Multimerin 2. (896 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
ENSPPAP00000016342CFC domain-containing protein. (142 aa)
NR2F2Uncharacterized protein. (333 aa)
FGFR1Fibroblast growth factor receptor. (812 aa)
BSGBasigin (Ok blood group). (362 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
SP1Sp1 transcription factor. (786 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
ANGPT2Angiopoietin 2. (495 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1248 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1108 aa)
LOC100979570Glutamine synthetase. (366 aa)
RAC1Uncharacterized protein. (224 aa)
PDCD10Programmed cell death 10. (212 aa)
ADGRB1Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1568 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (389 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
PTNPleiotrophin. (172 aa)
PATZ1POZ/BTB and AT hook containing zinc finger 1. (687 aa)
GRNGranulin precursor. (593 aa)
LOC100989777Uncharacterized protein. (191 aa)
ANXA3Annexin. (323 aa)
RRASRAS related. (176 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (493 aa)
CEACAM1Uncharacterized protein. (464 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
LOC100982269Uncharacterized protein. (390 aa)
RGCCRegulator of cell cycle. (137 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
CARD10Caspase recruitment domain family member 10. (934 aa)
PROX1Prospero homeobox 1. (737 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (655 aa)
SPRED1Sprouty related EVH1 domain containing 1. (444 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PRCPProlylcarboxypeptidase. (496 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
DNAJA4DnaJ heat shock protein family (Hsp40) member A4. (426 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
ANGPT1Angiopoietin 1. (498 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (824 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (826 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
RIN2Ras and Rab interactor 2. (943 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (605 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
SMOC2SPARC related modular calcium binding 2. (449 aa)
AMOTAngiomotin. (1085 aa)
BMPERBMP binding endothelial regulator. (685 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1413 aa)
CXCL13C-X-C motif chemokine. (109 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
VASH1Vasohibin 1. (365 aa)
STARD13StAR related lipid transfer domain containing 13. (1113 aa)
LGMNLegumain. (433 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
ATOH8Atonal bHLH transcription factor 8. (320 aa)
NR2E1Uncharacterized protein. (385 aa)
DAB2IPDAB2 interacting protein. (1155 aa)
NOS3Nitric oxide synthase 3. (997 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1686 aa)
SRPX2Sushi repeat containing protein X-linked 2. (465 aa)
FOXP1Forkhead box P1. (676 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
ENSPPAP00000033137Uncharacterized protein. (187 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
MEF2CMyocyte enhancer factor 2C. (482 aa)
NOTCH1Notch receptor 1. (2573 aa)
CD40CD40 molecule. (277 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (625 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
APOHApolipoprotein H. (345 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (850 aa)
JUPJunction plakoglobin. (745 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1306 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (260 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1011 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1321 aa)
GLULGlutamine synthetase. (373 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1058 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
CIB1Uncharacterized protein. (143 aa)
SEMA5ASemaphorin 5A. (1074 aa)
SP100SP100 nuclear antigen. (857 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
PDCD6Uncharacterized protein. (121 aa)
SLIT2Slit guidance ligand 2. (1410 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (761 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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