STRINGSTRING
PRKCE PRKCE FUT1 FUT1 NRP1 NRP1 EGF EGF VIL1 VIL1 CALR CALR SCARB1 SCARB1 ENSPPAP00000002689 ENSPPAP00000002689 EMC10 EMC10 BMPR2 BMPR2 NUS1 NUS1 ENSPPAP00000004239 ENSPPAP00000004239 THBS1 THBS1 FGFBP1 FGFBP1 RHOB RHOB LOC100987247 LOC100987247 CLASP2 CLASP2 SIRT1 SIRT1 GATA3 GATA3 VEGFA VEGFA ETS1 ETS1 ENSPPAP00000007948 ENSPPAP00000007948 AGT AGT WNT5A WNT5A ENSPPAP00000008146 ENSPPAP00000008146 TACR1 TACR1 GATA2 GATA2 ANGPT4 ANGPT4 EPB41L4B EPB41L4B JCAD JCAD HIF1A HIF1A AAMP AAMP RHOJ RHOJ BMP4 BMP4 ENSPPAP00000011278 ENSPPAP00000011278 ENSPPAP00000011507 ENSPPAP00000011507 ALOX12 ALOX12 LOC100968595 LOC100968595 TSTA3 TSTA3 PDGFB PDGFB SASH1 SASH1 EDN1 EDN1 ATP5F1A ATP5F1A LOC100987645 LOC100987645 WNT7A WNT7A RAB11A RAB11A ITGB3 ITGB3 ANXA1 ANXA1 TGFB2 TGFB2 ADAM9 ADAM9 BCAS3 BCAS3 TDGF1 TDGF1 HAS2 HAS2 RAB25 RAB25 CCBE1 CCBE1 ENSPPAP00000016342 ENSPPAP00000016342 FGFR1 FGFR1 BSG BSG TGFB1 TGFB1 PRKCA PRKCA SP1 SP1 PIK3CB PIK3CB PLCG1 PLCG1 ENPP2 ENPP2 ENSPPAP00000017733 ENSPPAP00000017733 ENSPPAP00000017965 ENSPPAP00000017965 CAPN7 CAPN7 RAC1 RAC1 BCAR1 BCAR1 ARF6 ARF6 GRN GRN HDAC6 HDAC6 LOC100989777 LOC100989777 ANXA3 ANXA3 RRAS RRAS ITGA3 ITGA3 FGF16 FGF16 TEK TEK LOC100982269 LOC100982269 ENSPPAP00000024234 ENSPPAP00000024234 PROX1 PROX1 MAP3K3 MAP3K3 AKT3 AKT3 PIK3CD PIK3CD HMOX1 HMOX1 GLIPR2 GLIPR2 ABL1 ABL1 ANGPT1 ANGPT1 MTOR MTOR IQSEC1 IQSEC1 PRKD1 PRKD1 RREB1 RREB1 EPB41L5 EPB41L5 FGF7 FGF7 PRKD2 PRKD2 ATP5F1B ATP5F1B RIN2 RIN2 NFE2L2 NFE2L2 ENSPPAP00000029328 ENSPPAP00000029328 HSPB1 HSPB1 SMOC2 SMOC2 AMOT AMOT MET MET MAP4K4 MAP4K4 PTK2B PTK2B ADAM17 ADAM17 MMP9 MMP9 LGMN LGMN ROCK2 ROCK2 ATOH8 ATOH8 NOS3 NOS3 PIK3C2A PIK3C2A SRPX2 SRPX2 FOXP1 FOXP1 FGF10 FGF10 ITGB1BP1 ITGB1BP1 RTN4 RTN4 HBEGF HBEGF PLCG2 PLCG2 CD40 CD40 GPI GPI PLK2 PLK2 AKT1 AKT1 SPARC SPARC SRC SRC FGF1 FGF1 DOCK1 DOCK1 GPLD1 GPLD1 DOCK5 DOCK5 CTSH CTSH ZC3H12A ZC3H12A NRP2 NRP2 ADGRA2 ADGRA2 FGF2 FGF2 P2RX4 P2RX4 HDAC7 HDAC7 IFNG IFNG STAT5A STAT5A FLT4 FLT4 MAPRE2 MAPRE2 KDR KDR PIK3CG PIK3CG PTGS2 PTGS2 HDAC9 HDAC9 CLASP1 CLASP1 VEGFC VEGFC CIB1 CIB1 SEMA5A SEMA5A PLPP3 PLPP3 TGFBR2 TGFBR2 PDCD6 PDCD6 FGF18 FGF18 ITGA2 ITGA2 PPM1F PPM1F
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (366 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
VIL1Villin 1. (827 aa)
CALRCalreticulin. (417 aa)
SCARB1Uncharacterized protein; Belongs to the CD36 family. (498 aa)
ENSPPAP00000002689CFC domain-containing protein. (158 aa)
EMC10Uncharacterized protein. (378 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1012 aa)
NUS1Uncharacterized protein. (220 aa)
ENSPPAP00000004239Uncharacterized protein. (268 aa)
THBS1Thrombospondin 1. (1173 aa)
FGFBP1Fibroblast growth factor binding protein 1. (234 aa)
RHOBRas homolog family member B. (196 aa)
LOC100987247CFC domain-containing protein. (170 aa)
CLASP2Uncharacterized protein. (1497 aa)
SIRT1Sirtuin 1. (693 aa)
GATA3GATA binding protein 3. (444 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (372 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
ENSPPAP00000007948Uncharacterized protein. (475 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
ENSPPAP00000008146Uncharacterized protein. (93 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
GATA2GATA binding protein 2. (480 aa)
ANGPT4Angiopoietin 4. (503 aa)
EPB41L4BErythrocyte membrane protein band 4.1 like 4B. (798 aa)
JCADJunctional cadherin 5 associated. (1352 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
AAMPAngio associated migratory cell protein. (434 aa)
RHOJRas homolog family member J. (214 aa)
BMP4TGF_BETA_2 domain-containing protein. (402 aa)
ENSPPAP00000011278Protein kinase domain-containing protein. (351 aa)
ENSPPAP00000011507Uncharacterized protein. (290 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
LOC100968595Uncharacterized protein. (860 aa)
TSTA3Tissue specific transplantation antigen P35B. (321 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SASH1SAM and SH3 domain containing 1. (1251 aa)
EDN1Endothelin 1. (212 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (570 aa)
LOC100987645Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
RAB11ARAB11A, member RAS oncogene family. (216 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (814 aa)
ANXA1Annexin. (346 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
HAS2Hyaluronan synthase 2. (552 aa)
RAB25RAB25, member RAS oncogene family. (213 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
ENSPPAP00000016342CFC domain-containing protein. (142 aa)
FGFR1Fibroblast growth factor receptor. (812 aa)
BSGBasigin (Ok blood group). (362 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
SP1Sp1 transcription factor. (786 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1248 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (915 aa)
ENSPPAP00000017733Uncharacterized protein. (66 aa)
ENSPPAP00000017965annotation not available (66 aa)
CAPN7Calpain 7; Belongs to the peptidase C2 family. (813 aa)
RAC1Uncharacterized protein. (224 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
ARF6Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (175 aa)
GRNGranulin precursor. (593 aa)
HDAC6Histone deacetylase 6. (1215 aa)
LOC100989777Uncharacterized protein. (191 aa)
ANXA3Annexin. (323 aa)
RRASRAS related. (176 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
LOC100982269Uncharacterized protein. (390 aa)
ENSPPAP00000024234Uncharacterized protein. (152 aa)
PROX1Prospero homeobox 1. (737 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (655 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (165 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
ANGPT1Angiopoietin 1. (498 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
IQSEC1IQ motif and Sec7 domain 1. (1096 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (824 aa)
RREB1Ras responsive element binding protein 1. (1742 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (826 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
RIN2Ras and Rab interactor 2. (943 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (605 aa)
ENSPPAP00000029328Profilin; Belongs to the profilin family. (117 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
SMOC2SPARC related modular calcium binding 2. (449 aa)
AMOTAngiomotin. (1085 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1413 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4. (1348 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
LGMNLegumain. (433 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
ATOH8Atonal bHLH transcription factor 8. (320 aa)
NOS3Nitric oxide synthase 3. (997 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1686 aa)
SRPX2Sushi repeat containing protein X-linked 2. (465 aa)
FOXP1Forkhead box P1. (676 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
RTN4Reticulon. (604 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CD40CD40 molecule. (277 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (625 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
SRCTyrosine-protein kinase. (458 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1870 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (850 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1870 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1306 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (260 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1011 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1321 aa)
MAPRE2Microtubule associated protein RP/EB family member 2. (327 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1058 aa)
CLASP1Cytoplasmic linker associated protein 1. (1550 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
CIB1Uncharacterized protein. (143 aa)
SEMA5ASemaphorin 5A. (1074 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa)
PDCD6Uncharacterized protein. (121 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (454 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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