STRINGSTRING
SIRT1 SIRT1 GRIA4 GRIA4 ENSPPAP00000011278 ENSPPAP00000011278 KIFAP3 KIFAP3 ALOX12 ALOX12 PPARG PPARG HSF1 HSF1 TIGAR TIGAR NRG1 NRG1 LOC100983911 LOC100983911 EDN1 EDN1 SIRT5 SIRT5 RGL2 RGL2 E2F3 E2F3 NKX2-5 NKX2-5 CAMK2D CAMK2D PAX8 PAX8 DIPK2A DIPK2A BMP7 BMP7 NUPR1 NUPR1 LTK LTK HEY2 HEY2 AMBRA1 AMBRA1 LRP6 LRP6 POU4F2 POU4F2 LYPD3 LYPD3 CAPN2 CAPN2 SLC7A5 SLC7A5 CFLAR CFLAR SIRT4 SIRT4 DNMT1 DNMT1 IGF1R IGF1R SMAD4 SMAD4 MAP2K4 MAP2K4 MFN2 MFN2 JAK2 JAK2 ENSPPAP00000025243 ENSPPAP00000025243 HMOX1 HMOX1 IL12B IL12B NFE2L2 NFE2L2 APOH APOH MAP3K5 MAP3K5 NOL3 NOL3 ATG5 ATG5 PPP1R10 PPP1R10 ARRB2 ARRB2 ATF4 ATF4 PTK2B PTK2B SOD2 SOD2 IL12A IL12A ENSPPAP00000031014 ENSPPAP00000031014 CDKN2A CDKN2A ENSPPAP00000041869 ENSPPAP00000041869 BNIP3 BNIP3 FNDC1 FNDC1 BAG3 BAG3 CAMK2A CAMK2A IFNG IFNG CCDC142 CCDC142 IGF1 IGF1 GATA6 GATA6 HAND2 HAND2 ENSPPAP00000002562 ENSPPAP00000002562 ZC3H12A ZC3H12A PDCD4 PDCD4 MYOCD MYOCD RBM10 RBM10 ENSPPAP00000035531 ENSPPAP00000035531 NACA NACA GATA4 GATA4 LOC100980724 LOC100980724 MDK MDK TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIRT1Sirtuin 1. (693 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
ENSPPAP00000011278Protein kinase domain-containing protein. (351 aa)
KIFAP3Kinesin associated protein 3. (792 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
HSF1Heat shock transcription factor 1. (490 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
NRG1Neuregulin 1. (645 aa)
LOC100983911BZIP domain-containing protein. (318 aa)
EDN1Endothelin 1. (212 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa)
RGL2Ral guanine nucleotide dissociation stimulator like 2. (777 aa)
E2F3E2F transcription factor 3. (420 aa)
NKX2-5NK2 homeobox 5. (325 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
PAX8Paired box 8. (456 aa)
DIPK2ADivergent protein kinase domain 2A. (423 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
LTKTyrosine-protein kinase receptor. (864 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
POU4F2POU domain protein. (406 aa)
LYPD3LY6/PLAUR domain containing 3. (351 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (700 aa)
SLC7A5Uncharacterized protein. (241 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (316 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1637 aa)
IGF1RTyrosine-protein kinase receptor. (1389 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (371 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
ENSPPAP00000025243E2F_TDP domain-containing protein. (273 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (605 aa)
APOHApolipoprotein H. (345 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1356 aa)
NOL3CARD domain-containing protein. (219 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
PPP1R10Protein phosphatase 1 regulatory subunit 10. (940 aa)
ARRB2Arrestin beta 2. (447 aa)
ATF4Activating transcription factor 4. (340 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
ENSPPAP00000031014Protein kinase domain-containing protein. (371 aa)
CDKN2AUncharacterized protein. (173 aa)
ENSPPAP00000041869NAC-A/B domain-containing protein. (117 aa)
BNIP3BCL2 interacting protein 3. (252 aa)
FNDC1Fibronectin type III domain containing 1. (1891 aa)
BAG3BCL2 associated athanogene 3. (521 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
CCDC142Coiled-coil domain containing 142. (743 aa)
IGF1IlGF domain-containing protein. (196 aa)
GATA6Uncharacterized protein. (402 aa)
HAND2Uncharacterized protein. (66 aa)
ENSPPAP00000002562BZIP domain-containing protein. (314 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
PDCD4Programmed cell death 4. (469 aa)
MYOCDMyocardin. (986 aa)
RBM10RNA binding motif protein 10. (1006 aa)
ENSPPAP00000035531E2F_TDP domain-containing protein. (281 aa)
NACANascent polypeptide associated complex subunit alpha. (923 aa)
GATA4GATA binding protein 4. (396 aa)
LOC100980724BZIP domain-containing protein. (359 aa)
MDKMidkine. (143 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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