STRINGSTRING
COL1A1 COL1A1 BAMBI BAMBI ZNF703 ZNF703 LOXL2 LOXL2 MDK MDK EMP2 EMP2 SMAD4 SMAD4 BMP4 BMP4 DAB2 DAB2 LRG1 LRG1 TCF7L2 TCF7L2 BMP2 BMP2 TGFB2 TGFB2 CRB2 CRB2 TGFBR1 TGFBR1 ENG ENG EZH2 EZH2 TGFB1 TGFB1 TGFB3 TGFB3 ENSPPAP00000018618 ENSPPAP00000018618 BMP7 BMP7 HDAC2 HDAC2 TBX20 TBX20 TIAM1 TIAM1 TGFBR2 TGFBR2 SMAD3 SMAD3 FERMT2 FERMT2 ALX1 ALX1 AXIN2 AXIN2 ISL1 ISL1 JAG1 JAG1 RGCC RGCC SMAD2 SMAD2 CTNNB1 CTNNB1 IL6 IL6 GLIPR2 GLIPR2 MTOR MTOR TGFB1I1 TGFB1I1 ACVR1 ACVR1 OLFM1 OLFM1 SDCBP SDCBP WWTR1 WWTR1 PDPN PDPN NOTCH1 NOTCH1 IL1B IL1B SNAI1 SNAI1 GCNT2 GCNT2 BCL9L BCL9L ENSPPAP00000038018 ENSPPAP00000038018 LEF1 LEF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL1A1Collagen type I alpha 1 chain. (1463 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
ZNF703Zinc finger protein 703. (482 aa)
LOXL2Lysyl oxidase like 2. (780 aa)
MDKMidkine. (143 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMP4TGF_BETA_2 domain-containing protein. (402 aa)
DAB2DAB adaptor protein 2. (752 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
TCF7L2Transcription factor 7 like 2. (555 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CRB2Crumbs cell polarity complex component 2. (1083 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ENGEndoglin. (658 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ENSPPAP00000018618Uncharacterized protein. (263 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (510 aa)
TBX20Uncharacterized protein. (379 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
FERMT2Fermitin family member 2. (695 aa)
ALX1ALX homeobox 1. (326 aa)
AXIN2Axin 2. (843 aa)
ISL1ISL LIM homeobox 1. (349 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
RGCCRegulator of cell cycle. (137 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CTNNB1Catenin beta 1. (781 aa)
IL6Uncharacterized protein. (198 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (165 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (470 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
OLFM1Olfactomedin 1. (458 aa)
SDCBPUncharacterized protein. (324 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
PDPNPodoplanin. (237 aa)
NOTCH1Notch receptor 1. (2573 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa)
BCL9LBCL9 like. (1483 aa)
ENSPPAP00000038018PDZ domain-containing protein. (271 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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