(30 nodes) Regulation of macrophage derived foam cell differentiation network (Pan paniscus)

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Your Input:
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (549 aa)
	PLA2G2A	Phospholipase A(2). (144 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	APOB	Apolipoprotein B. (4535 aa)
	PLA2G5	Phospholipase A(2). (138 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
	ABCA5	ATP binding cassette subfamily A member 5. (1631 aa)
	ABCG1	ABC transporter domain-containing protein. (807 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (485 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (461 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	PLA2G3	Phospholipase A2 group III. (509 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (814 aa)
	CRP	Uncharacterized protein. (102 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	PF4	C-X-C motif chemokine. (101 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
	MSR1	Macrophage scavenger receptor 1. (460 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (453 aa)
	LOC100990946	PA2c domain-containing protein. (147 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (467 aa)
	CETP	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (466 aa)
	ALOX15B	Arachidonate 15-lipoxygenase type B. (676 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2264 aa)
	CSF2	Colony stimulating factor 2. (144 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (456 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (286 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	ABCG1	ENSPPAP00000035173	ENSPPAP00000007960	ATP binding cassette subfamily A member 1.	ABC transporter domain-containing protein.	0.439
ABCA1	APOB	ENSPPAP00000035173	ENSPPAP00000002804	ATP binding cassette subfamily A member 1.	Apolipoprotein B.	0.706
ABCA1	CD36	ENSPPAP00000035173	ENSPPAP00000001139	ATP binding cassette subfamily A member 1.	CD36 molecule; Belongs to the CD36 family.	0.635
ABCA1	CETP	ENSPPAP00000035173	ENSPPAP00000033549	ATP binding cassette subfamily A member 1.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.687
ABCA1	LPL	ENSPPAP00000035173	ENSPPAP00000007103	ATP binding cassette subfamily A member 1.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.497
ABCA1	NR1H2	ENSPPAP00000035173	ENSPPAP00000008101	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 2.	0.966
ABCA1	NR1H3	ENSPPAP00000035173	ENSPPAP00000032317	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 3.	0.856
ABCA1	PPARA	ENSPPAP00000035173	ENSPPAP00000033410	ATP binding cassette subfamily A member 1.	Peroxisome proliferator activated receptor alpha.	0.680
ABCA1	PPARG	ENSPPAP00000035173	ENSPPAP00000011736	ATP binding cassette subfamily A member 1.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.699
ABCG1	ABCA1	ENSPPAP00000007960	ENSPPAP00000035173	ABC transporter domain-containing protein.	ATP binding cassette subfamily A member 1.	0.439
ABCG1	APOB	ENSPPAP00000007960	ENSPPAP00000002804	ABC transporter domain-containing protein.	Apolipoprotein B.	0.573
ABCG1	CD36	ENSPPAP00000007960	ENSPPAP00000001139	ABC transporter domain-containing protein.	CD36 molecule; Belongs to the CD36 family.	0.541
ABCG1	CETP	ENSPPAP00000007960	ENSPPAP00000033549	ABC transporter domain-containing protein.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.641
ABCG1	LPL	ENSPPAP00000007960	ENSPPAP00000007103	ABC transporter domain-containing protein.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.453
ABCG1	NR1H2	ENSPPAP00000007960	ENSPPAP00000008101	ABC transporter domain-containing protein.	Nuclear receptor subfamily 1 group H member 2.	0.699
ABCG1	NR1H3	ENSPPAP00000007960	ENSPPAP00000032317	ABC transporter domain-containing protein.	Nuclear receptor subfamily 1 group H member 3.	0.775
ABCG1	PPARA	ENSPPAP00000007960	ENSPPAP00000033410	ABC transporter domain-containing protein.	Peroxisome proliferator activated receptor alpha.	0.509
ABCG1	PPARG	ENSPPAP00000007960	ENSPPAP00000011736	ABC transporter domain-containing protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.606
ADIPOQ	AGT	ENSPPAP00000042063	ENSPPAP00000007994	Adiponectin, C1Q and collagen domain containing.	Angiotensinogen; Belongs to the serpin family.	0.515
ADIPOQ	APOB	ENSPPAP00000042063	ENSPPAP00000002804	Adiponectin, C1Q and collagen domain containing.	Apolipoprotein B.	0.577