(81 nodes) Regulation of glucose transmembrane transport network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CLIP3	CAP-Gly domain containing linker protein 3. (547 aa)
	OCLN	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (521 aa)
	FFAR4	Free fatty acid receptor 4. (377 aa)
	FABP5	Fatty acid binding protein 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
	IGF1	IlGF domain-containing protein. (196 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	IRS1	Insulin receptor substrate 1. (1242 aa)
	STXBP4	Syntaxin binding protein 4. (553 aa)
	GRB10	Growth factor receptor bound protein 10. (594 aa)
	RSC1A1	Regulator of solute carriers 1. (618 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (204 aa)
	ENSPPAP00000006969	Uncharacterized protein. (584 aa)
	CREBL2	BZIP domain-containing protein. (180 aa)
	SORBS1	Sorbin and SH3 domain containing 1. (1292 aa)
	ENSPPAP00000009275	Uncharacterized protein. (269 aa)
	ENSPPAP00000009601	Uncharacterized protein; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (91 aa)
	INSR	Tyrosine-protein kinase receptor. (1362 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	LOC100987414	Intelectin 1. (313 aa)
	PEA15	Proliferation and apoptosis adaptor protein 15. (151 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	TRIB3	Tribbles pseudokinase 3. (385 aa)
	RNASEL	Ribonuclease L. (741 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1040 aa)
	GIP	Uncharacterized protein. (94 aa)
	KLF15	Kruppel like factor 15. (416 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (545 aa)
	EDN1	Endothelin 1. (212 aa)
	ITLN2	Intelectin 2. (325 aa)
	SLC1A2	Amino acid transporter. (574 aa)
	CLTCL1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1639 aa)
	ENSPPAP00000015127	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (130 aa)
	SELENOS	Uncharacterized protein. (218 aa)
	CAPN10	Calpain 10; Belongs to the peptidase C2 family. (672 aa)
	OSTN	Osteocrin. (133 aa)
	ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase 1. (949 aa)
	STXBP3	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (524 aa)
	FGF21	Uncharacterized protein. (147 aa)
	ENSPPAP00000021143	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (125 aa)
	ENSPPAP00000021339	PID domain-containing protein. (181 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
	SIRT6	Sirtuin 6. (355 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
	OPN3	Opsin 3; Belongs to the G-protein coupled receptor 1 family. (408 aa)
	ENSPPAP00000024034	Uncharacterized protein. (541 aa)
	MEF2A	Myocyte enhancer factor 2A. (505 aa)
	POU4F2	POU domain protein. (406 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	ENSPPAP00000025160	Tyrosine-protein kinase. (483 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	ARPP19	cAMP regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (131 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (766 aa)
	C3	Complement C3. (1614 aa)
	PLA2G1B	Phospholipase A(2). (148 aa)
	ENSPPAP00000026998	Uncharacterized protein. (493 aa)
	GSK3A	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (463 aa)
	ENSPPAP00000028661	Protein kinase C. (574 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (605 aa)
	C2CD5	C2 calcium dependent domain containing 5. (1084 aa)
	ENSPPAP00000029143	Uncharacterized protein. (511 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (709 aa)
	RTN2	Reticulon. (545 aa)
	HK2	Hexokinase 2. (917 aa)
	YES1	Tyrosine-protein kinase. (548 aa)
	ENSPPAP00000032115	Uncharacterized protein. (883 aa)
	RHOQ	Uncharacterized protein. (345 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	AKT1	Non-specific serine/threonine protein kinase. (501 aa)
	ASPSCR1	ASPSCR1 tether for SLC2A4, UBX domain containing. (645 aa)
	LOC100971425	Uncharacterized protein. (217 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (647 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	NR4A3	Nuclear receptor domain-containing protein. (359 aa)
	ITLN1	Fibrinogen C-terminal domain-containing protein. (313 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (448 aa)
	C1QTNF12	C1q and TNF related 12. (277 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (881 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (286 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	AKT1	ENSPPAP00000042063	ENSPPAP00000034920	Adiponectin, C1Q and collagen domain containing.	Non-specific serine/threonine protein kinase.	0.545
ADIPOQ	APPL1	ENSPPAP00000042063	ENSPPAP00000029773	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.689
ADIPOQ	APPL2	ENSPPAP00000042063	ENSPPAP00000038121	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.485
ADIPOQ	EDN1	ENSPPAP00000042063	ENSPPAP00000013795	Adiponectin, C1Q and collagen domain containing.	Endothelin 1.	0.420
ADIPOQ	ENPP1	ENSPPAP00000042063	ENSPPAP00000016892	Adiponectin, C1Q and collagen domain containing.	Ectonucleotide pyrophosphatase/phosphodiesterase 1.	0.408
ADIPOQ	FGF21	ENSPPAP00000042063	ENSPPAP00000020459	Adiponectin, C1Q and collagen domain containing.	Uncharacterized protein.	0.576
ADIPOQ	IGF1	ENSPPAP00000042063	ENSPPAP00000003648	Adiponectin, C1Q and collagen domain containing.	IlGF domain-containing protein.	0.661
ADIPOQ	IL1B	ENSPPAP00000042063	ENSPPAP00000034853	Adiponectin, C1Q and collagen domain containing.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.662
ADIPOQ	IRS1	ENSPPAP00000042063	ENSPPAP00000004215	Adiponectin, C1Q and collagen domain containing.	Insulin receptor substrate 1.	0.605
ADIPOQ	ITLN1	ENSPPAP00000042063	ENSPPAP00000038591	Adiponectin, C1Q and collagen domain containing.	Fibrinogen C-terminal domain-containing protein.	0.524
ADIPOQ	LEP	ENSPPAP00000042063	ENSPPAP00000025238	Adiponectin, C1Q and collagen domain containing.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.951
ADIPOQ	LOC100987414	ENSPPAP00000042063	ENSPPAP00000010925	Adiponectin, C1Q and collagen domain containing.	Intelectin 1.	0.524
ADIPOQ	TNF	ENSPPAP00000042063	ENSPPAP00000004174	Adiponectin, C1Q and collagen domain containing.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.684
AKT1	ADIPOQ	ENSPPAP00000034920	ENSPPAP00000042063	Non-specific serine/threonine protein kinase.	Adiponectin, C1Q and collagen domain containing.	0.545
AKT1	AKT2	ENSPPAP00000034920	ENSPPAP00000010803	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.987
AKT1	APPL1	ENSPPAP00000034920	ENSPPAP00000029773	Non-specific serine/threonine protein kinase.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.931
AKT1	APPL2	ENSPPAP00000034920	ENSPPAP00000038121	Non-specific serine/threonine protein kinase.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.787
AKT1	BRAF	ENSPPAP00000034920	ENSPPAP00000025756	Non-specific serine/threonine protein kinase.	B-Raf proto-oncogene, serine/threonine kinase.	0.596
AKT1	EDN1	ENSPPAP00000034920	ENSPPAP00000013795	Non-specific serine/threonine protein kinase.	Endothelin 1.	0.544
AKT1	ENSPPAP00000006969	ENSPPAP00000034920	ENSPPAP00000006969	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.477