(48 nodes) Positive regulation of glucose transmembrane transport network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	GIP	Uncharacterized protein. (94 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1040 aa)
	RNASEL	Ribonuclease L. (741 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	LOC100987414	Intelectin 1. (313 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	INSR	Tyrosine-protein kinase receptor. (1362 aa)
	ENSPPAP00000009601	Uncharacterized protein; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (91 aa)
	ENSPPAP00000009275	Uncharacterized protein. (269 aa)
	SORBS1	Sorbin and SH3 domain containing 1. (1292 aa)
	CREBL2	BZIP domain-containing protein. (180 aa)
	ENSPPAP00000006969	Uncharacterized protein. (584 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (204 aa)
	IRS1	Insulin receptor substrate 1. (1242 aa)
	IGF1	IlGF domain-containing protein. (196 aa)
	OCLN	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (521 aa)
	CLIP3	CAP-Gly domain containing linker protein 3. (547 aa)
	KLF15	Kruppel like factor 15. (416 aa)
	ITLN2	Intelectin 2. (325 aa)
	SLC1A2	Amino acid transporter. (574 aa)
	CLTCL1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1639 aa)
	CAPN10	Calpain 10; Belongs to the peptidase C2 family. (672 aa)
	FGF21	Uncharacterized protein. (147 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
	OPN3	Opsin 3; Belongs to the G-protein coupled receptor 1 family. (408 aa)
	ENSPPAP00000024034	Uncharacterized protein. (541 aa)
	MEF2A	Myocyte enhancer factor 2A. (505 aa)
	POU4F2	POU domain protein. (406 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	ARPP19	cAMP regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (131 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (766 aa)
	C3	Complement C3. (1614 aa)
	ENSPPAP00000026998	Uncharacterized protein. (493 aa)
	ENSPPAP00000028661	Protein kinase C. (574 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (605 aa)
	C2CD5	C2 calcium dependent domain containing 5. (1084 aa)
	ENSPPAP00000029143	Uncharacterized protein. (511 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (709 aa)
	RHOQ	Uncharacterized protein. (345 aa)
	AKT1	Non-specific serine/threonine protein kinase. (501 aa)
	LOC100971425	Uncharacterized protein. (217 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	NR4A3	Nuclear receptor domain-containing protein. (359 aa)
	ITLN1	Fibrinogen C-terminal domain-containing protein. (313 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
	C1QTNF12	C1q and TNF related 12. (277 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (881 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (286 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	AKT1	ENSPPAP00000042063	ENSPPAP00000034920	Adiponectin, C1Q and collagen domain containing.	Non-specific serine/threonine protein kinase.	0.545
ADIPOQ	APPL1	ENSPPAP00000042063	ENSPPAP00000029773	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.689
ADIPOQ	FGF21	ENSPPAP00000042063	ENSPPAP00000020459	Adiponectin, C1Q and collagen domain containing.	Uncharacterized protein.	0.576
ADIPOQ	IGF1	ENSPPAP00000042063	ENSPPAP00000003648	Adiponectin, C1Q and collagen domain containing.	IlGF domain-containing protein.	0.661
ADIPOQ	IRS1	ENSPPAP00000042063	ENSPPAP00000004215	Adiponectin, C1Q and collagen domain containing.	Insulin receptor substrate 1.	0.605
ADIPOQ	ITLN1	ENSPPAP00000042063	ENSPPAP00000038591	Adiponectin, C1Q and collagen domain containing.	Fibrinogen C-terminal domain-containing protein.	0.524
ADIPOQ	LOC100987414	ENSPPAP00000042063	ENSPPAP00000010925	Adiponectin, C1Q and collagen domain containing.	Intelectin 1.	0.524
AKT1	ADIPOQ	ENSPPAP00000034920	ENSPPAP00000042063	Non-specific serine/threonine protein kinase.	Adiponectin, C1Q and collagen domain containing.	0.545
AKT1	AKT2	ENSPPAP00000034920	ENSPPAP00000010803	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.987
AKT1	APPL1	ENSPPAP00000034920	ENSPPAP00000029773	Non-specific serine/threonine protein kinase.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.931
AKT1	BRAF	ENSPPAP00000034920	ENSPPAP00000025756	Non-specific serine/threonine protein kinase.	B-Raf proto-oncogene, serine/threonine kinase.	0.596
AKT1	ENSPPAP00000006969	ENSPPAP00000034920	ENSPPAP00000006969	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.477
AKT1	ENSPPAP00000009275	ENSPPAP00000034920	ENSPPAP00000009275	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.477
AKT1	ENSPPAP00000024034	ENSPPAP00000034920	ENSPPAP00000024034	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.477
AKT1	ENSPPAP00000029143	ENSPPAP00000034920	ENSPPAP00000029143	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.553
AKT1	FGF21	ENSPPAP00000034920	ENSPPAP00000020459	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.403
AKT1	IGF1	ENSPPAP00000034920	ENSPPAP00000003648	Non-specific serine/threonine protein kinase.	IlGF domain-containing protein.	0.767
AKT1	IRS1	ENSPPAP00000034920	ENSPPAP00000004215	Non-specific serine/threonine protein kinase.	Insulin receptor substrate 1.	0.808
AKT1	MAPK14	ENSPPAP00000034920	ENSPPAP00000038351	Non-specific serine/threonine protein kinase.	Mitogen-activated protein kinase.	0.983
AKT1	NFE2L2	ENSPPAP00000034920	ENSPPAP00000028975	Non-specific serine/threonine protein kinase.	Nuclear factor, erythroid 2 like 2.	0.813