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BMP6 BMP6 BMP15 BMP15 BMP5 BMP5 GDF2 GDF2 BMPR2 BMPR2 GDF5 GDF5 SMAD4 SMAD4 TWSG1 TWSG1 BMP4 BMP4 DAB2 DAB2 PPARG PPARG LEFTY2 LEFTY2 BMP2 BMP2 TGFB2 TGFB2 BMP8A BMP8A TGFBR1 TGFBR1 ENG ENG TGFB1 TGFB1 LEFTY1 LEFTY1 TGFB3 TGFB3 NODAL NODAL ENSPPAP00000018618 ENSPPAP00000018618 BMP7 BMP7 RBPMS RBPMS GDF3 GDF3 GDF9 GDF9 ACVRL1 ACVRL1 GDF6 GDF6 GDF11 GDF11 INHBA INHBA ACVR1 ACVR1 GDF15 GDF15 SDCBP SDCBP BMPR1A BMPR1A BMP3 BMP3 GDF7 GDF7 GDF10 GDF10 BMP10 BMP10 ENSPPAP00000038018 ENSPPAP00000038018 HFE HFE TTK TTK INHA INHA INHBE INHBE INHBC INHBC TGFBR2 TGFBR2 ACVR2A ACVR2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP6Bone morphogenetic protein 6. (453 aa)
BMP15Bone morphogenetic protein 15. (369 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
GDF2Growth differentiation factor 2. (429 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1012 aa)
GDF5Growth differentiation factor 5. (501 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
BMP4TGF_BETA_2 domain-containing protein. (402 aa)
DAB2DAB adaptor protein 2. (752 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
LEFTY2Left-right determination factor. (366 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMP8ATGF_BETA_2 domain-containing protein. (239 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ENGEndoglin. (658 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LEFTY1Left-right determination factor 1. (325 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
NODALNodal growth differentiation factor. (347 aa)
ENSPPAP00000018618Uncharacterized protein. (263 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
RBPMSRNA binding protein, mRNA processing factor. (197 aa)
GDF3Growth differentiation factor 3. (364 aa)
GDF9Growth differentiation factor 9. (367 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
GDF6TGF_BETA_2 domain-containing protein. (370 aa)
GDF11Growth differentiation factor 11. (398 aa)
INHBAInhibin subunit beta A. (426 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
GDF15Growth differentiation factor 15. (308 aa)
SDCBPUncharacterized protein. (324 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
GDF7TGF_BETA_2 domain-containing protein. (361 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ENSPPAP00000038018PDZ domain-containing protein. (271 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
TTKTTK protein kinase. (856 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
INHBEInhibin subunit beta E. (350 aa)
INHBCInhibin subunit beta C. (351 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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