(38 nodes) Schwann cell differentiation network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NAB1	NGFI-A binding protein 1. (487 aa)
	FA2H	Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
	ITGB4	Integrin beta. (1821 aa)
	SH3TC2	SH3 domain and tetratricopeptide repeats 2. (1259 aa)
	NDRG1	N-myc downstream regulated 1. (394 aa)
	ENSPPAP00000006569	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (141 aa)
	SOD1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
	ARHGEF10	Rho guanine nucleotide exchange factor 10. (1369 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	SH3TC1	SH3 domain and tetratricopeptide repeats 1. (1336 aa)
	ADGRG6	Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1250 aa)
	NRG1	Neuregulin 1. (645 aa)
	ILK	Integrin linked kinase. (533 aa)
	ADAM22	ADAM metallopeptidase domain 22. (889 aa)
	CNTNAP1	Contactin associated protein 1. (1384 aa)
	NF1	Neurofibromin 1. (2839 aa)
	SKI	SKI proto-oncogene. (666 aa)
	NAB2	NGFI-A binding protein 2. (525 aa)
	MED12	Mediator complex subunit 12. (2182 aa)
	LGI4	Leucine rich repeat LGI family member 4. (537 aa)
	PRX	Periaxin. (1459 aa)
	LAMB2	Laminin subunit beta 2. (1780 aa)
	ENSPPAP00000023041	Uncharacterized protein. (426 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
	DICER1	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1922 aa)
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1344 aa)
	DAG1	Dystroglycan 1. (895 aa)
	EGR2	Early growth response 2. (476 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
	GPC1	Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (636 aa)
	MPP5	Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
	NTRK2	Tyrosine-protein kinase receptor. (838 aa)
	PARD3	Par-3 family cell polarity regulator. (1316 aa)
	AKT1	Non-specific serine/threonine protein kinase. (501 aa)
	MYOC	Myocilin. (504 aa)
	PLEC	Plectin. (4523 aa)
	NCMAP	Non-compact myelin associated protein. (102 aa)
	SLC25A46	Solute carrier family 25 member 46; Belongs to the mitochondrial carrier (TC 2.A.29) family. (418 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM22	LGI4	ENSPPAP00000013827	ENSPPAP00000019430	ADAM metallopeptidase domain 22.	Leucine rich repeat LGI family member 4.	0.835
ADGRG6	EGR2	ENSPPAP00000012756	ENSPPAP00000025890	Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family.	Early growth response 2.	0.485
AKT1	AKT2	ENSPPAP00000034920	ENSPPAP00000010803	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.987
AKT1	DICER1	ENSPPAP00000034920	ENSPPAP00000024009	Non-specific serine/threonine protein kinase.	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.456
AKT1	ERBB3	ENSPPAP00000034920	ENSPPAP00000024596	Non-specific serine/threonine protein kinase.	Erb-b2 receptor tyrosine kinase 3.	0.654
AKT1	ILK	ENSPPAP00000034920	ENSPPAP00000013259	Non-specific serine/threonine protein kinase.	Integrin linked kinase.	0.990
AKT1	ITGB4	ENSPPAP00000034920	ENSPPAP00000004234	Non-specific serine/threonine protein kinase.	Integrin beta.	0.447
AKT1	NF1	ENSPPAP00000034920	ENSPPAP00000014745	Non-specific serine/threonine protein kinase.	Neurofibromin 1.	0.554
AKT1	PARD3	ENSPPAP00000034920	ENSPPAP00000031723	Non-specific serine/threonine protein kinase.	Par-3 family cell polarity regulator.	0.425
AKT1	SIRT2	ENSPPAP00000034920	ENSPPAP00000025973	Non-specific serine/threonine protein kinase.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.542
AKT2	AKT1	ENSPPAP00000010803	ENSPPAP00000034920	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.987
AKT2	ERBB3	ENSPPAP00000010803	ENSPPAP00000024596	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Erb-b2 receptor tyrosine kinase 3.	0.414
AKT2	ILK	ENSPPAP00000010803	ENSPPAP00000013259	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Integrin linked kinase.	0.945
CNTNAP1	MPP5	ENSPPAP00000014084	ENSPPAP00000027553	Contactin associated protein 1.	Membrane palmitoylated protein 5; Belongs to the MAGUK family.	0.433
DAG1	LAMB2	ENSPPAP00000025410	ENSPPAP00000022726	Dystroglycan 1.	Laminin subunit beta 2.	0.781
DAG1	PLEC	ENSPPAP00000025410	ENSPPAP00000039003	Dystroglycan 1.	Plectin.	0.672
DAG1	PRX	ENSPPAP00000025410	ENSPPAP00000020856	Dystroglycan 1.	Periaxin.	0.415
DICER1	AKT1	ENSPPAP00000024009	ENSPPAP00000034920	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	Non-specific serine/threonine protein kinase.	0.456
EGR2	ADGRG6	ENSPPAP00000025890	ENSPPAP00000012756	Early growth response 2.	Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family.	0.485
EGR2	ENSPPAP00000023041	ENSPPAP00000025890	ENSPPAP00000023041	Early growth response 2.	Uncharacterized protein.	0.452