(35 nodes) Negative regulation of macroautophagy network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	CLEC16A	C-type lectin domain containing 16A. (1053 aa)
	PHF23	PHD finger protein 23. (403 aa)
	SCFD1	Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (614 aa)
	LRRK2	Leucine rich repeat kinase 2. (2527 aa)
	FEZ2	Fasciculation and elongation protein zeta 2. (366 aa)
	AKT1	Non-specific serine/threonine protein kinase. (501 aa)
	UBQLN4	Ubiquilin 4. (601 aa)
	LZTS1	Leucine zipper tumor suppressor 1. (596 aa)
	BECN1	Beclin 1. (450 aa)
	RUBCN	Rubicon autophagy regulator. (1179 aa)
	MTM1	Myotubularin 1. (603 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	SMG1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2429 aa)
	HMOX1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
	TSC1	TSC complex subunit 1. (1164 aa)
	TSC2	TSC complex subunit 2. (1807 aa)
	NUPR1	Nuclear protein 1, transcriptional regulator. (82 aa)
	POLDIP2	DNA polymerase delta interacting protein 2. (368 aa)
	ENSPPAP00000018201	Uncharacterized protein. (201 aa)
	NRBP2	Nuclear receptor binding protein 2. (501 aa)
	TMEM39B	Transmembrane protein 39B. (492 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1278 aa)
	QSOX1	Sulfhydryl oxidase. (817 aa)
	PINK1	PTEN induced kinase 1. (554 aa)
	USP36	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (967 aa)
	RNF41	Ring finger protein 41. (317 aa)
	USP30	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (517 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (270 aa)
	FEZ1	Fasciculation and elongation protein zeta 1. (363 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	CHMP4B	Charged multivesicular body protein 4B. (219 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
	SMCR8	SMCR8-C9orf72 complex subunit. (937 aa)
	TMEM39A	Transmembrane protein 39A. (488 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1277 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	BECN1	ENSPPAP00000034920	ENSPPAP00000030010	Non-specific serine/threonine protein kinase.	Beclin 1.	0.757
AKT1	HMOX1	ENSPPAP00000034920	ENSPPAP00000026071	Non-specific serine/threonine protein kinase.	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	0.586
AKT1	MTOR	ENSPPAP00000034920	ENSPPAP00000026600	Non-specific serine/threonine protein kinase.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.997
AKT1	PIK3CA	ENSPPAP00000034920	ENSPPAP00000010140	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.993
AKT1	PINK1	ENSPPAP00000034920	ENSPPAP00000013889	Non-specific serine/threonine protein kinase.	PTEN induced kinase 1.	0.441
AKT1	SMG1	ENSPPAP00000034920	ENSPPAP00000026385	Non-specific serine/threonine protein kinase.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.564
AKT1	TP53	ENSPPAP00000034920	ENSPPAP00000011040	Non-specific serine/threonine protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.975
AKT1	TSC1	ENSPPAP00000034920	ENSPPAP00000024667	Non-specific serine/threonine protein kinase.	TSC complex subunit 1.	0.979
AKT1	TSC2	ENSPPAP00000034920	ENSPPAP00000021735	Non-specific serine/threonine protein kinase.	TSC complex subunit 2.	0.985
BECN1	AKT1	ENSPPAP00000030010	ENSPPAP00000034920	Beclin 1.	Non-specific serine/threonine protein kinase.	0.757
BECN1	HMOX1	ENSPPAP00000030010	ENSPPAP00000026071	Beclin 1.	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	0.410
BECN1	MTOR	ENSPPAP00000030010	ENSPPAP00000026600	Beclin 1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.688
BECN1	PIK3CA	ENSPPAP00000030010	ENSPPAP00000010140	Beclin 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.468
BECN1	PINK1	ENSPPAP00000030010	ENSPPAP00000013889	Beclin 1.	PTEN induced kinase 1.	0.976
BECN1	RUBCN	ENSPPAP00000030010	ENSPPAP00000027836	Beclin 1.	Rubicon autophagy regulator.	0.991
BECN1	TP53	ENSPPAP00000030010	ENSPPAP00000011040	Beclin 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.718
BECN1	TSC2	ENSPPAP00000030010	ENSPPAP00000021735	Beclin 1.	TSC complex subunit 2.	0.465
CHMP4B	ENSPPAP00000018201	ENSPPAP00000010578	ENSPPAP00000018201	Charged multivesicular body protein 4B.	Uncharacterized protein.	0.901
CLEC16A	RNF41	ENSPPAP00000034353	ENSPPAP00000012436	C-type lectin domain containing 16A.	Ring finger protein 41.	0.689
EHMT2	TP53	ENSPPAP00000015818	ENSPPAP00000011040	Euchromatic histone lysine methyltransferase 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.770