(21 nodes) RISC complex network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	LIMD1	LIM domains containing 1. (676 aa)
	ENSPPAP00000008263	DRBM domain-containing protein. (296 aa)
	DHX9	DExH-box helicase 9. (1270 aa)
	TARBP2	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
	AGO3	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
	ENSPPAP00000019077	Uncharacterized protein. (54 aa)
	DDX6	DEAD-box helicase 6; Belongs to the DEAD box helicase family. (483 aa)
	AGO1	Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
	EIF4E	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (246 aa)
	PRKRA	Protein activator of interferon induced protein kinase EIF2AK2. (261 aa)
	SND1	Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa)
	ENSPPAP00000039065	Uncharacterized protein. (350 aa)
	DCP2	Decapping mRNA 2. (417 aa)
	ENSPPAP00000035130	Uncharacterized protein. (433 aa)
	XPO5	Exportin 5. (1188 aa)
	ENSPPAP00000034250	Uncharacterized protein; Belongs to the DEAD box helicase family. (413 aa)
	ENSPPAP00000032433	Uncharacterized protein. (64 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (873 aa)
	ENSPPAP00000026880	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (222 aa)
	DICER1	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1922 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	ENSPPAP00000023500	ENSPPAP00000029760	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.996
AGO1	AGO3	ENSPPAP00000023500	ENSPPAP00000017917	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.935
AGO1	AGO4	ENSPPAP00000023500	ENSPPAP00000017422	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.882
AGO1	DCP2	ENSPPAP00000023500	ENSPPAP00000038818	Argonaute RISC component 1; Belongs to the argonaute family.	Decapping mRNA 2.	0.678
AGO1	DDX6	ENSPPAP00000023500	ENSPPAP00000023454	Argonaute RISC component 1; Belongs to the argonaute family.	DEAD-box helicase 6; Belongs to the DEAD box helicase family.	0.898
AGO1	DHX9	ENSPPAP00000023500	ENSPPAP00000014111	Argonaute RISC component 1; Belongs to the argonaute family.	DExH-box helicase 9.	0.552
AGO1	DICER1	ENSPPAP00000023500	ENSPPAP00000024009	Argonaute RISC component 1; Belongs to the argonaute family.	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.995
AGO1	EIF4E	ENSPPAP00000023500	ENSPPAP00000042127	Argonaute RISC component 1; Belongs to the argonaute family.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.777
AGO1	ENSPPAP00000008263	ENSPPAP00000023500	ENSPPAP00000008263	Argonaute RISC component 1; Belongs to the argonaute family.	DRBM domain-containing protein.	0.900
AGO1	ENSPPAP00000026880	ENSPPAP00000023500	ENSPPAP00000026880	Argonaute RISC component 1; Belongs to the argonaute family.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.571
AGO1	ENSPPAP00000034250	ENSPPAP00000023500	ENSPPAP00000034250	Argonaute RISC component 1; Belongs to the argonaute family.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.691
AGO1	ENSPPAP00000035130	ENSPPAP00000023500	ENSPPAP00000035130	Argonaute RISC component 1; Belongs to the argonaute family.	Uncharacterized protein.	0.691
AGO1	LIMD1	ENSPPAP00000023500	ENSPPAP00000005907	Argonaute RISC component 1; Belongs to the argonaute family.	LIM domains containing 1.	0.441
AGO1	PRKRA	ENSPPAP00000023500	ENSPPAP00000041383	Argonaute RISC component 1; Belongs to the argonaute family.	Protein activator of interferon induced protein kinase EIF2AK2.	0.853
AGO1	SND1	ENSPPAP00000023500	ENSPPAP00000040819	Argonaute RISC component 1; Belongs to the argonaute family.	Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.	0.563
AGO1	TARBP2	ENSPPAP00000023500	ENSPPAP00000014549	Argonaute RISC component 1; Belongs to the argonaute family.	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]	0.900
AGO1	XPO5	ENSPPAP00000023500	ENSPPAP00000034339	Argonaute RISC component 1; Belongs to the argonaute family.	Exportin 5.	0.821
AGO2	AGO1	ENSPPAP00000029760	ENSPPAP00000023500	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Argonaute RISC component 1; Belongs to the argonaute family.	0.996
AGO2	AGO3	ENSPPAP00000029760	ENSPPAP00000017917	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.983
AGO2	AGO4	ENSPPAP00000029760	ENSPPAP00000017422	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.942