(29 nodes) Protein autoprocessing network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HTRA2	HtrA serine peptidase 2. (458 aa)
	PCSK1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (753 aa)
	CASP4	Caspase 4; Belongs to the peptidase C14A family. (321 aa)
	ENSPPAP00000038923	Uncharacterized protein. (200 aa)
	PISD	Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (409 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	HJV	Hemojuvelin BMP co-receptor. (425 aa)
	FXN	Frataxin. (210 aa)
	PCSK2	Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. (638 aa)
	CTSE	Cathepsin E; Belongs to the peptidase A1 family. (396 aa)
	PRR14L	Proline rich 14 like. (2151 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (402 aa)
	MYRFL	Myelin regulatory factor like. (910 aa)
	CAPN2	Calpain 2; Belongs to the peptidase C2 family. (700 aa)
	SPRTN	SprT-like N-terminal domain. (489 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (293 aa)
	AFG3L2	AFG3 like matrix AAA peptidase subunit 2. (797 aa)
	PIDD1	P53-induced death domain protein 1. (910 aa)
	OMA1	OMA1 zinc metallopeptidase. (524 aa)
	F12	Coagulation factor XII. (615 aa)
	DHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
	TMPRSS2	Transmembrane serine protease 2; Belongs to the peptidase S1 family. (496 aa)
	KLK6	Kallikrein related peptidase 6; Belongs to the peptidase S1 family. (244 aa)
	FAM111A	Family with sequence similarity 111 member A. (594 aa)
	CASP1	Caspase 1; Belongs to the peptidase C14A family. (403 aa)
	CTSL	Cathepsin L; Belongs to the peptidase C1 family. (333 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (692 aa)
	MYRF	Myelin regulatory factor. (1151 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFG3L2	FXN	ENSPPAP00000001458	ENSPPAP00000034028	AFG3 like matrix AAA peptidase subunit 2.	Frataxin.	0.501
AFG3L2	OMA1	ENSPPAP00000001458	ENSPPAP00000003074	AFG3 like matrix AAA peptidase subunit 2.	OMA1 zinc metallopeptidase.	0.658
CASP1	CASP4	ENSPPAP00000014107	ENSPPAP00000039371	Caspase 1; Belongs to the peptidase C14A family.	Caspase 4; Belongs to the peptidase C14A family.	0.798
CASP1	CASP6	ENSPPAP00000014107	ENSPPAP00000027782	Caspase 1; Belongs to the peptidase C14A family.	Caspase 6; Belongs to the peptidase C14A family.	0.674
CASP1	PARP1	ENSPPAP00000014107	ENSPPAP00000036168	Caspase 1; Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.432
CASP1	PIDD1	ENSPPAP00000014107	ENSPPAP00000002424	Caspase 1; Belongs to the peptidase C14A family.	P53-induced death domain protein 1.	0.552
CASP4	CASP1	ENSPPAP00000039371	ENSPPAP00000014107	Caspase 4; Belongs to the peptidase C14A family.	Caspase 1; Belongs to the peptidase C14A family.	0.798
CASP6	CASP1	ENSPPAP00000027782	ENSPPAP00000014107	Caspase 6; Belongs to the peptidase C14A family.	Caspase 1; Belongs to the peptidase C14A family.	0.674
CASP6	PARP1	ENSPPAP00000027782	ENSPPAP00000036168	Caspase 6; Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.521
CASP6	PIDD1	ENSPPAP00000027782	ENSPPAP00000002424	Caspase 6; Belongs to the peptidase C14A family.	P53-induced death domain protein 1.	0.463
CTSE	CTSL	ENSPPAP00000029168	ENSPPAP00000014596	Cathepsin E; Belongs to the peptidase A1 family.	Cathepsin L; Belongs to the peptidase C1 family.	0.542
CTSE	PCSK9	ENSPPAP00000029168	ENSPPAP00000018371	Cathepsin E; Belongs to the peptidase A1 family.	Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...]	0.518
CTSL	CTSE	ENSPPAP00000014596	ENSPPAP00000029168	Cathepsin L; Belongs to the peptidase C1 family.	Cathepsin E; Belongs to the peptidase A1 family.	0.542
CTSL	TMPRSS2	ENSPPAP00000014596	ENSPPAP00000004485	Cathepsin L; Belongs to the peptidase C1 family.	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.761
DHH	IHH	ENSPPAP00000003961	ENSPPAP00000021798	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.955
DHH	SHH	ENSPPAP00000003961	ENSPPAP00000020557	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.958
F12	PIDD1	ENSPPAP00000003784	ENSPPAP00000002424	Coagulation factor XII.	P53-induced death domain protein 1.	0.598
FAM111A	SPRTN	ENSPPAP00000012199	ENSPPAP00000027394	Family with sequence similarity 111 member A.	SprT-like N-terminal domain.	0.417
FXN	AFG3L2	ENSPPAP00000034028	ENSPPAP00000001458	Frataxin.	AFG3 like matrix AAA peptidase subunit 2.	0.501
IHH	DHH	ENSPPAP00000021798	ENSPPAP00000003961	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.955