STRINGSTRING
CENPO CENPO PARP6 PARP6 PARP9 PARP9 XXYLT1 XXYLT1 ENSPPAP00000000014 ENSPPAP00000000014 ENSPPAP00000000033 ENSPPAP00000000033 APRT APRT ENSPPAP00000002979 ENSPPAP00000002979 GXYLT1 GXYLT1 PNP PNP PARP4 PARP4 ART5 ART5 ENSPPAP00000008219 ENSPPAP00000008219 SIRT4 SIRT4 VWA5B2 VWA5B2 UMPS UMPS FAM162A FAM162A TNKS TNKS POGLUT2 POGLUT2 TIPARP TIPARP ART1 ART1 POGLUT3 POGLUT3 PARP12 PARP12 PARP8 PARP8 PARP16 PARP16 QTRT1 QTRT1 SIRT5 SIRT5 ART4 ART4 ENSPPAP00000018727 ENSPPAP00000018727 PARP15 PARP15 ANKRD39 ANKRD39 XYLT1 XYLT1 SIRT3 SIRT3 UPP1 UPP1 SIRT6 SIRT6 LACC1 LACC1 HPRT1 HPRT1 PARP2 PARP2 SIRT2 SIRT2 VWA5A VWA5A UPP2 UPP2 RXYLT1 RXYLT1 TYMP TYMP POGLUT1 POGLUT1 GXYLT2 GXYLT2 ART3 ART3 LARGE2 LARGE2 MTAP MTAP QPRT QPRT ZC3HAV1 ZC3HAV1 VWA5B1 VWA5B1 QTRT2 QTRT2 PARP14 PARP14 LARGE1 LARGE1 TNKS2 TNKS2 ENSPPAP00000035598 ENSPPAP00000035598 XYLT2 XYLT2 PARP3 PARP3 PARP1 PARP1 NAMPT NAMPT PARP10 PARP10 PPAT PPAT ENSPPAP00000038383 ENSPPAP00000038383 FAM162B FAM162B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CENPOUncharacterized protein. (290 aa)
PARP6Poly [ADP-ribose] polymerase. (630 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (855 aa)
XXYLT1Xyloside xylosyltransferase 1. (393 aa)
ENSPPAP00000000014Uncharacterized protein. (52 aa)
ENSPPAP00000000033Uncharacterized protein. (261 aa)
APRTAdenine phosphoribosyltransferase. (180 aa)
ENSPPAP00000002979Purine nucleoside phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (263 aa)
GXYLT1Glucoside xylosyltransferase 1. (366 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
PARP4Poly [ADP-ribose] polymerase. (1724 aa)
ART5NAD(P)(+)--arginine ADP-ribosyltransferase. (291 aa)
ENSPPAP00000008219Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (540 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (316 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1242 aa)
UMPSUridine monophosphate synthetase. (479 aa)
FAM162AFamily with sequence similarity 162 member A. (149 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
POGLUT2Protein O-glucosyltransferase 2. (502 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (657 aa)
ART1NAD(P)(+)--arginine ADP-ribosyltransferase. (327 aa)
POGLUT3Protein O-glucosyltransferase 3. (467 aa)
PARP12Poly(ADP-ribose) polymerase family member 12. (641 aa)
PARP8Poly [ADP-ribose] polymerase. (854 aa)
PARP16Poly [ADP-ribose] polymerase. (323 aa)
QTRT1Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (403 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa)
ART4NAD(P)(+)--arginine ADP-ribosyltransferase. (329 aa)
ENSPPAP00000018727Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (486 aa)
PARP15Poly [ADP-ribose] polymerase. (616 aa)
ANKRD39ANK_REP_REGION domain-containing protein. (240 aa)
XYLT1Xylosyltransferase 1. (838 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (342 aa)
UPP1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (310 aa)
SIRT6Sirtuin 6. (355 aa)
LACC1Uncharacterized protein. (430 aa)
HPRT1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (210 aa)
PARP2Poly [ADP-ribose] polymerase. (565 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
VWA5AVon Willebrand factor A domain containing 5A. (786 aa)
UPP2Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (374 aa)
RXYLT1Ribitol xylosyltransferase 1. (443 aa)
TYMPUncharacterized protein. (145 aa)
POGLUT1Protein O-glucosyltransferase 1. (392 aa)
GXYLT2Glucoside xylosyltransferase 2. (361 aa)
ART3NAD(P)(+)--arginine ADP-ribosyltransferase. (369 aa)
LARGE2LARGE xylosyl- and glucuronyltransferase 2. (728 aa)
MTAPS-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (323 aa)
QPRTNicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (299 aa)
ZC3HAV1Uncharacterized protein. (1024 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1215 aa)
QTRT2Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (427 aa)
PARP14Poly [ADP-ribose] polymerase. (1801 aa)
LARGE1Uncharacterized protein. (286 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
ENSPPAP00000035598Uncharacterized protein. (205 aa)
XYLT2Xylosyltransferase 2. (823 aa)
PARP3Poly [ADP-ribose] polymerase. (539 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (475 aa)
PARP10Poly [ADP-ribose] polymerase. (1037 aa)
PPATAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (517 aa)
ENSPPAP00000038383Uncharacterized protein. (41 aa)
FAM162BFamily with sequence similarity 162 member B. (162 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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