(45 nodes) Calcium-ion regulated exocytosis network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SYT11	Synaptotagmin 11. (431 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (525 aa)
	ARHGAP17	Rho GTPase activating protein 17. (854 aa)
	SYT8	Synaptotagmin 8. (387 aa)
	SYT3	Synaptotagmin 3. (590 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (923 aa)
	CADPS	Uncharacterized protein. (1293 aa)
	UNC13B	Uncharacterized protein. (4343 aa)
	SCIN	Scinderin. (715 aa)
	STX1A	Syntaxin 1A; Belongs to the syntaxin family. (288 aa)
	SYT10	Synaptotagmin 10. (523 aa)
	ARL8B	ADP ribosylation factor like GTPase 8B; Belongs to the small GTPase superfamily. Arf family. (186 aa)
	SYT15	C2 domain-containing protein. (311 aa)
	STXBP1	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (594 aa)
	VAMP3	V-SNARE coiled-coil homology domain-containing protein. (116 aa)
	UNC13D	Unc-13 homolog D. (1079 aa)
	SYT17	Synaptotagmin 17. (474 aa)
	SYT13	Synaptotagmin 13. (426 aa)
	UNC13C	C2 domain-containing protein. (135 aa)
	RAB3A	RAB3A, member RAS oncogene family. (220 aa)
	SYT1	Synaptotagmin 1. (422 aa)
	CLTRN	Collectrin domain-containing protein. (222 aa)
	SYT12	Synaptotagmin 12. (420 aa)
	CADPS2	Calcium dependent secretion activator 2. (1296 aa)
	ZP4	Zona pellucida glycoprotein 4. (540 aa)
	UNC13A	Unc-13 homolog A. (1628 aa)
	NLRP5	NLR family pyrin domain containing 5. (1181 aa)
	SYT5	Synaptotagmin 5. (408 aa)
	VAMP7	Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (260 aa)
	SYT6	Uncharacterized protein. (539 aa)
	DOC2B	Uncharacterized protein. (360 aa)
	SYT4	Synaptotagmin 4. (425 aa)
	SYT2	Synaptotagmin 2. (419 aa)
	MYH9	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1964 aa)
	SDF4	Uncharacterized protein. (447 aa)
	EQTN	Equatorin. (294 aa)
	SYT7	Uncharacterized protein. (686 aa)
	STX1B	Syntaxin 1B; Belongs to the syntaxin family. (293 aa)
	SYT9	Synaptotagmin 9. (491 aa)
	ENSPPAP00000037156	Uncharacterized protein. (167 aa)
	RIMS1	Regulating synaptic membrane exocytosis 1. (1692 aa)
	RIMS2	Uncharacterized protein. (1356 aa)
	RIMS3	Regulating synaptic membrane exocytosis 3. (308 aa)
	NOTCH1	Notch receptor 1. (2573 aa)
	SYN2	Synapsin II. (501 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CADPS	RIMS2	ENSPPAP00000028276	ENSPPAP00000035265	Uncharacterized protein.	Uncharacterized protein.	0.428
CADPS	STXBP1	ENSPPAP00000028276	ENSPPAP00000002636	Uncharacterized protein.	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family.	0.402
CADPS	UNC13B	ENSPPAP00000028276	ENSPPAP00000027590	Uncharacterized protein.	Uncharacterized protein.	0.585
CADPS2	RIMS2	ENSPPAP00000013815	ENSPPAP00000035265	Calcium dependent secretion activator 2.	Uncharacterized protein.	0.428
DOC2B	RAB3A	ENSPPAP00000021262	ENSPPAP00000011334	Uncharacterized protein.	RAB3A, member RAS oncogene family.	0.565
DOC2B	UNC13A	ENSPPAP00000021262	ENSPPAP00000014633	Uncharacterized protein.	Unc-13 homolog A.	0.496
DOC2B	UNC13B	ENSPPAP00000021262	ENSPPAP00000027590	Uncharacterized protein.	Uncharacterized protein.	0.729
NLRP5	ZP4	ENSPPAP00000017303	ENSPPAP00000014594	NLR family pyrin domain containing 5.	Zona pellucida glycoprotein 4.	0.560
RAB3A	DOC2B	ENSPPAP00000011334	ENSPPAP00000021262	RAB3A, member RAS oncogene family.	Uncharacterized protein.	0.565
RAB3A	RIMS1	ENSPPAP00000011334	ENSPPAP00000036070	RAB3A, member RAS oncogene family.	Regulating synaptic membrane exocytosis 1.	0.871
RAB3A	RIMS2	ENSPPAP00000011334	ENSPPAP00000035265	RAB3A, member RAS oncogene family.	Uncharacterized protein.	0.901
RAB3A	RIMS3	ENSPPAP00000011334	ENSPPAP00000034535	RAB3A, member RAS oncogene family.	Regulating synaptic membrane exocytosis 3.	0.529
RAB3A	STX1A	ENSPPAP00000011334	ENSPPAP00000042600	RAB3A, member RAS oncogene family.	Syntaxin 1A; Belongs to the syntaxin family.	0.620
RAB3A	STX1B	ENSPPAP00000011334	ENSPPAP00000038004	RAB3A, member RAS oncogene family.	Syntaxin 1B; Belongs to the syntaxin family.	0.506
RAB3A	STXBP1	ENSPPAP00000011334	ENSPPAP00000002636	RAB3A, member RAS oncogene family.	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family.	0.738
RAB3A	SYN2	ENSPPAP00000011334	ENSPPAP00000031378	RAB3A, member RAS oncogene family.	Synapsin II.	0.637
RAB3A	SYT1	ENSPPAP00000011334	ENSPPAP00000012148	RAB3A, member RAS oncogene family.	Synaptotagmin 1.	0.960
RAB3A	SYT11	ENSPPAP00000011334	ENSPPAP00000033002	RAB3A, member RAS oncogene family.	Synaptotagmin 11.	0.566
RAB3A	SYT12	ENSPPAP00000011334	ENSPPAP00000013199	RAB3A, member RAS oncogene family.	Synaptotagmin 12.	0.472
RAB3A	SYT2	ENSPPAP00000011334	ENSPPAP00000024454	RAB3A, member RAS oncogene family.	Synaptotagmin 2.	0.679