(40 nodes) Histone-lysine N-methyltransferase activity network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NSD2	Nuclear receptor binding SET domain protein 2. (1365 aa)
	KMT5A	SET domain-containing protein. (326 aa)
	ENSPPAP00000013473	Uncharacterized protein. (518 aa)
	SUV39H1	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
	PRDM16	PR/SET domain 16. (1324 aa)
	SETD1A	Uncharacterized protein. (1397 aa)
	KMT2C	Lysine methyltransferase 2C. (4798 aa)
	SUV39H2	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1278 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
	KMT2A	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3967 aa)
	PRDM7	KRAB-related domain-containing protein. (454 aa)
	ASH1L	ASH1 like histone lysine methyltransferase. (2923 aa)
	EHMT1	Euchromatic histone lysine methyltransferase 1. (1298 aa)
	DOT1L	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1637 aa)
	SMYD1	SET and MYND domain containing 1. (497 aa)
	N6AMT1	N-6 adenine-specific DNA methyltransferase 1. (214 aa)
	SETD3	Protein-histidine N-methyltransferase. (594 aa)
	SMYD5	SMYD family member 5. (420 aa)
	SMYD3	SET and MYND domain containing 3. (428 aa)
	SETBP1	SET binding protein 1. (1395 aa)
	KMT2B	Lysine methyltransferase 2B. (2339 aa)
	KMT5B	Lysine methyltransferase 5B. (885 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (735 aa)
	SETMAR	SET domain and mariner transposase fusion gene. (684 aa)
	SETDB2	SET domain bifurcated histone lysine methyltransferase 2. (719 aa)
	SETD4	SET domain containing 4. (440 aa)
	SETD5	SET domain containing 5. (1461 aa)
	SETDB1	SET domain bifurcated histone lysine methyltransferase 1. (1292 aa)
	IZUMO4	IZUMO family member 4. (232 aa)
	SETD1B	SET domain containing 1B, histone lysine methyltransferase. (1926 aa)
	KMT5C	Lysine methyltransferase 5C. (390 aa)
	ENSPPAP00000000062	MTS domain-containing protein. (220 aa)
	KMT2D	Lysine methyltransferase 2D. (4780 aa)
	NSD3	Nuclear receptor binding SET domain protein 3. (1437 aa)
	NSD1	Nuclear receptor binding SET domain protein 1. (2697 aa)
	MECOM	MDS1 and EVI1 complex locus. (1230 aa)
	SETD7	Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2536 aa)
	ENSPPAP00000008195	SET domain-containing protein. (347 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASH1L	DOT1L	ENSPPAP00000017744	ENSPPAP00000021622	ASH1 like histone lysine methyltransferase.	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	0.466
ASH1L	KMT2A	ENSPPAP00000017744	ENSPPAP00000017046	ASH1 like histone lysine methyltransferase.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.	0.546
ASH1L	KMT2B	ENSPPAP00000017744	ENSPPAP00000030370	ASH1 like histone lysine methyltransferase.	Lysine methyltransferase 2B.	0.526
ASH1L	KMT2C	ENSPPAP00000017744	ENSPPAP00000014882	ASH1 like histone lysine methyltransferase.	Lysine methyltransferase 2C.	0.453
ASH1L	KMT2D	ENSPPAP00000017744	ENSPPAP00000000683	ASH1 like histone lysine methyltransferase.	Lysine methyltransferase 2D.	0.551
ASH1L	KMT5B	ENSPPAP00000017744	ENSPPAP00000031633	ASH1 like histone lysine methyltransferase.	Lysine methyltransferase 5B.	0.509
ASH1L	NSD1	ENSPPAP00000017744	ENSPPAP00000003050	ASH1 like histone lysine methyltransferase.	Nuclear receptor binding SET domain protein 1.	0.408
ASH1L	NSD2	ENSPPAP00000017744	ENSPPAP00000011362	ASH1 like histone lysine methyltransferase.	Nuclear receptor binding SET domain protein 2.	0.447
ASH1L	SETD2	ENSPPAP00000017744	ENSPPAP00000007706	ASH1 like histone lysine methyltransferase.	SET domain containing 2, histone lysine methyltransferase.	0.788
ASH1L	SETD3	ENSPPAP00000017744	ENSPPAP00000027019	ASH1 like histone lysine methyltransferase.	Protein-histidine N-methyltransferase.	0.495
ASH1L	SETD5	ENSPPAP00000017744	ENSPPAP00000036328	ASH1 like histone lysine methyltransferase.	SET domain containing 5.	0.425
ASH1L	SMYD3	ENSPPAP00000017744	ENSPPAP00000028999	ASH1 like histone lysine methyltransferase.	SET and MYND domain containing 3.	0.420
DOT1L	ASH1L	ENSPPAP00000021622	ENSPPAP00000017744	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	ASH1 like histone lysine methyltransferase.	0.466
DOT1L	EHMT1	ENSPPAP00000021622	ENSPPAP00000019989	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Euchromatic histone lysine methyltransferase 1.	0.450
DOT1L	EHMT2	ENSPPAP00000021622	ENSPPAP00000015818	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Euchromatic histone lysine methyltransferase 2.	0.566
DOT1L	ENSPPAP00000008195	ENSPPAP00000021622	ENSPPAP00000008195	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	SET domain-containing protein.	0.523
DOT1L	EZH2	ENSPPAP00000021622	ENSPPAP00000016828	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.707
DOT1L	KMT2A	ENSPPAP00000021622	ENSPPAP00000017046	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.	0.681
DOT1L	KMT5A	ENSPPAP00000021622	ENSPPAP00000012217	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	SET domain-containing protein.	0.455
DOT1L	KMT5B	ENSPPAP00000021622	ENSPPAP00000031633	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Lysine methyltransferase 5B.	0.453