(50 nodes) Nucleobase-containing compound kinase activity network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	NME1-NME2	Nucleoside diphosphate kinase. (292 aa)
	ENSPPAP00000043144	ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (141 aa)
	NT5C2	5'-nucleotidase, cytosolic II. (577 aa)
	AK9	Adenylate kinase 9. (1910 aa)
	AK6	Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (172 aa)
	UCK1	Uridine-cytidine kinase; Belongs to the uridine kinase family. (277 aa)
	CLP1	Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (436 aa)
	NME9	NME/NM23 family member 9; Belongs to the NDK family. (269 aa)
	DTYMK	Deoxythymidylate kinase. (212 aa)
	N4BP2L1	NEDD4 binding protein 2 like 1. (244 aa)
	MPP1	Membrane palmitoylated protein 1; Belongs to the MAGUK family. (466 aa)
	DLG2	Discs large MAGUK scaffold protein 2. (939 aa)
	CASK	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
	NME7	Nucleoside diphosphate kinase 7; Belongs to the NDK family. (376 aa)
	ENSPPAP00000033562	Uncharacterized protein. (148 aa)
	AK2	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (232 aa)
	UCKL1	Uridine-cytidine kinase; Belongs to the uridine kinase family. (555 aa)
	MAGI3	Uncharacterized protein. (758 aa)
	DGUOK	Deoxyguanosine kinase. (277 aa)
	AK4	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
	CMPK2	Uncharacterized protein. (59 aa)
	NME6	Nucleoside diphosphate kinase. (186 aa)
	TK2	Thymidine kinase 2. (307 aa)
	DCK	dNK domain-containing protein. (317 aa)
	LOC100987625	ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (221 aa)
	AK8	Adenylate kinase 8; Belongs to the adenylate kinase family. (479 aa)
	CARD11	Caspase recruitment domain family member 11. (1154 aa)
	NOL9	Nucleolar protein 9. (702 aa)
	AK1	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (210 aa)
	AK5	Adenylate kinase 5; Belongs to the adenylate kinase family. (562 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
	AK3	Adenylate kinase 3; Belongs to the adenylate kinase family. (230 aa)
	N4BP2	NEDD4 binding protein 2. (1770 aa)
	ADK	Adenosine kinase. (362 aa)
	ENSPPAP00000017962	ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (172 aa)
	ENSPPAP00000016340	Uncharacterized protein. (137 aa)
	GUK1	Guanylate kinase-like domain-containing protein. (272 aa)
	TK1	Thymidine kinase. (276 aa)
	NME4	Nucleoside diphosphate kinase. (164 aa)
	NME3	Nucleoside diphosphate kinase. (169 aa)
	NME5	NME/NM23 family member 5; Belongs to the NDK family. (212 aa)
	UCK2	Uridine-cytidine kinase 2. (271 aa)
	ENSPPAP00000010232	Uncharacterized protein. (157 aa)
	AK7	Adenylate kinase 7. (686 aa)
	CMPK1	Uncharacterized protein; Belongs to the adenylate kinase family. (212 aa)
	LRGUK	Leucine rich repeats and guanylate kinase domain containing. (825 aa)
	LOC100994033	Nucleoside diphosphate kinase. (146 aa)
	PNKP	Polynucleotide kinase 3'-phosphatase. (521 aa)
	REC114	REC114 meiotic recombination protein. (265 aa)
	LOC100977684	Uncharacterized protein; Belongs to the adenylate kinase family. (167 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADK	AK1	ENSPPAP00000019957	ENSPPAP00000022193	Adenosine kinase.	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	0.949
ADK	AK2	ENSPPAP00000019957	ENSPPAP00000032106	Adenosine kinase.	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	0.954
ADK	AK3	ENSPPAP00000019957	ENSPPAP00000020736	Adenosine kinase.	Adenylate kinase 3; Belongs to the adenylate kinase family.	0.934
ADK	AK4	ENSPPAP00000019957	ENSPPAP00000030294	Adenosine kinase.	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	0.928
ADK	AK5	ENSPPAP00000019957	ENSPPAP00000021446	Adenosine kinase.	Adenylate kinase 5; Belongs to the adenylate kinase family.	0.920
ADK	AK6	ENSPPAP00000019957	ENSPPAP00000041246	Adenosine kinase.	Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily.	0.909
ADK	AK7	ENSPPAP00000019957	ENSPPAP00000008612	Adenosine kinase.	Adenylate kinase 7.	0.927
ADK	AK8	ENSPPAP00000019957	ENSPPAP00000024572	Adenosine kinase.	Adenylate kinase 8; Belongs to the adenylate kinase family.	0.947
ADK	AK9	ENSPPAP00000019957	ENSPPAP00000042405	Adenosine kinase.	Adenylate kinase 9.	0.943
ADK	DCK	ENSPPAP00000019957	ENSPPAP00000025963	Adenosine kinase.	dNK domain-containing protein.	0.938
ADK	LOC100987625	ENSPPAP00000019957	ENSPPAP00000025007	Adenosine kinase.	ADK_lid domain-containing protein; Belongs to the adenylate kinase family.	0.563
ADK	NT5C2	ENSPPAP00000019957	ENSPPAP00000042974	Adenosine kinase.	5'-nucleotidase, cytosolic II.	0.922
ADK	TK2	ENSPPAP00000019957	ENSPPAP00000026628	Adenosine kinase.	Thymidine kinase 2.	0.404
AK1	ADK	ENSPPAP00000022193	ENSPPAP00000019957	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenosine kinase.	0.949
AK1	AK2	ENSPPAP00000022193	ENSPPAP00000032106	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	0.469
AK1	AK3	ENSPPAP00000022193	ENSPPAP00000020736	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenylate kinase 3; Belongs to the adenylate kinase family.	0.437
AK1	AK4	ENSPPAP00000022193	ENSPPAP00000030294	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	0.529
AK1	AK7	ENSPPAP00000022193	ENSPPAP00000008612	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenylate kinase 7.	0.726
AK1	AK8	ENSPPAP00000022193	ENSPPAP00000024572	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenylate kinase 8; Belongs to the adenylate kinase family.	0.482
AK1	AK9	ENSPPAP00000022193	ENSPPAP00000042405	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenylate kinase 9.	0.878