STRINGSTRING
HTR2A HTR2A TRPV1 TRPV1 NPY1R NPY1R ITGA2 ITGA2 PAWR PAWR PENK PENK PTGS2 PTGS2 NTSR1 NTSR1 GRM1 GRM1 SCN10A SCN10A P2RX4 P2RX4 OPRM1 OPRM1 OPRL1 OPRL1 CXCL12 CXCL12 LXN LXN CALCA CALCA NIPSNAP1 NIPSNAP1 NLGN2 NLGN2 ARRB2 ARRB2 PROK2 PROK2 UCHL1 UCHL1 MAPK3 MAPK3 BACE1 BACE1 ASIC3 ASIC3 IL12B IL12B SCN1A SCN1A PHF24 PHF24 POMK POMK FYN FYN RETREG1 RETREG1 CDK5 CDK5 HOXB8 HOXB8 KCND2 KCND2 ENSPPAP00000022875 ENSPPAP00000022875 NTRK1 NTRK1 TMEM120A TMEM120A GRIN2A GRIN2A SCN9A SCN9A AQP1 AQP1 MECP2 MECP2 IAPP IAPP CCL2 CCL2 TAC1 TAC1 SCN3B SCN3B TRPA1 TRPA1 CHRNB2 CHRNB2 HOXD1 HOXD1 PRDM12 PRDM12 PTGES PTGES EDN1 EDN1 GIP GIP MMP24 MMP24 TAC4 TAC4 OPRK1 OPRK1 IL18 IL18 TACR1 TACR1 EDNRB EDNRB NR2F6 NR2F6 P2RY1 P2RY1 EPHB1 EPHB1 KCNK4 KCNK4 MME MME ANO1 ANO1 KCNA2 KCNA2 P2RX7 P2RX7 KCNA1 KCNA1 CNR2 CNR2 NDN NDN CCR2 CCR2 BDKRB1 BDKRB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
NPY1RNeuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
PAWRPro-apoptotic WT1 regulator. (320 aa)
PENKProenkephalin. (267 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (405 aa)
GRM1Glutamate metabotropic receptor 1. (1194 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1959 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (492 aa)
OPRL1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (370 aa)
CXCL12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
LXNLatexin. (222 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
NIPSNAP1Nipsnap homolog 1. (258 aa)
NLGN2COesterase domain-containing protein. (833 aa)
ARRB2Arrestin beta 2. (447 aa)
PROK2Prokineticin 2. (119 aa)
UCHL1UCH_1 domain-containing protein. (198 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (311 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
ASIC3Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (549 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1974 aa)
PHF24PHD finger protein 24. (400 aa)
POMKProtein O-mannose kinase. (350 aa)
FYNTyrosine-protein kinase. (537 aa)
RETREG1Uncharacterized protein. (356 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
HOXB8Homeobox B8. (243 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
ENSPPAP00000022875Uncharacterized protein. (107 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
TMEM120ATransmembrane protein 120A. (354 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
SCN9ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1977 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (493 aa)
IAPPIslet amyloid polypeptide. (89 aa)
CCL2C-C motif chemokine. (99 aa)
TAC1Tachykinin precursor 1. (134 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1109 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (502 aa)
HOXD1Homeobox domain-containing protein. (295 aa)
PRDM12Uncharacterized protein. (295 aa)
PTGESProstaglandin E synthase. (152 aa)
EDN1Endothelin 1. (212 aa)
GIPUncharacterized protein. (94 aa)
MMP24Matrix metallopeptidase 24. (612 aa)
TAC4Tachykinin 4. (113 aa)
OPRK1Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
NR2F6Uncharacterized protein. (326 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
EPHB1EPH receptor B1. (984 aa)
KCNK4Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (392 aa)
MMEMembrane metalloendopeptidase. (750 aa)
ANO1Anoctamin. (950 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
CNR2Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
NDNMAGE domain-containing protein. (261 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
BDKRB1G_PROTEIN_RECEP_F1_2 domain-containing protein. (284 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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