(103 nodes) Gland morphogenesis network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NRP1	Neuropilin; Belongs to the neuropilin family. (924 aa)
	LOC100992709	FERM domain-containing protein. (517 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	ENSPPAP00000001955	Uncharacterized protein. (170 aa)
	PLXND1	Uncharacterized protein. (52 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
	EPHA2	EPH receptor A2. (976 aa)
	HOXD13	Homeobox domain-containing protein. (230 aa)
	SLC9A3R1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
	ENSPPAP00000003962	Uncharacterized protein. (69 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	SERPINB5	Serpin family B member 5; Belongs to the serpin family. (375 aa)
	EDAR	Ectodysplasin A receptor. (496 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	DDR1	Discoidin domain receptor tyrosine kinase 1. (920 aa)
	IGFBP5	Insulin like growth factor binding protein 5. (272 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
	NKX3-1	NK3 homeobox 1. (223 aa)
	CAPN1	Calpain 1; Belongs to the peptidase C2 family. (733 aa)
	HOXB13	Homeobox B13. (284 aa)
	LRP5	LDL receptor related protein 5. (1839 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (521 aa)
	PGR	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. (636 aa)
	TWSG1	Twisted gastrulation BMP signaling modulator 1. (223 aa)
	ESRP2	Epithelial splicing regulatory protein 2. (713 aa)
	TBX3	T-box transcription factor 3. (723 aa)
	TGM2	Transglutaminase 2. (687 aa)
	BMP4	TGF_BETA_2 domain-containing protein. (402 aa)
	RARG	Retinoic acid receptor gamma. (464 aa)
	CRIP1	LIM zinc-binding domain-containing protein. (77 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (795 aa)
	SCRIB	Scribble planar cell polarity protein. (1656 aa)
	PML	Uncharacterized protein. (836 aa)
	STAT6	Signal transducer and activator of transcription. (852 aa)
	NFIB	CTF/NF-I domain-containing protein. (202 aa)
	NOTCH2	Notch receptor 2. (2254 aa)
	NTN1	Netrin 1. (528 aa)
	FEM1B	Fem-1 homolog B. (627 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	TBX2	T-box transcription factor 2. (622 aa)
	LAMA5	Laminin subunit alpha 5. (3648 aa)
	ARG1	Arginase. (322 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	BCL2	BCL2 apoptosis regulator. (193 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	FGL1	Fibrinogen like 1. (312 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
	TNC	Tenascin C. (2201 aa)
	NRG3	Neuregulin 3. (719 aa)
	LRRC1	Leucine rich repeat containing 1. (524 aa)
	SFRP1	NTR domain-containing protein. (178 aa)
	SOSTDC1	Sclerostin domain containing 1. (230 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	MSN	Moesin. (591 aa)
	SELENOH	Selenoprotein H. (121 aa)
	FGFR2	Fibroblast growth factor receptor. (822 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	IL6	Uncharacterized protein. (198 aa)
	NKX2-3	Homeobox domain-containing protein. (303 aa)
	ELF3	E74 like ETS transcription factor 3. (375 aa)
	DAG1	Dystroglycan 1. (895 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	EDA	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (223 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	PHB2	Prohibitin. (299 aa)
	VDR	Vitamin D receptor. (477 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	MKI67	Marker of proliferation Ki-67. (3217 aa)
	CSMD1	CUB and Sushi multiple domains 1. (3565 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (484 aa)
	AR	Androgen receptor. (882 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (777 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	NOTCH1	Notch receptor 1. (2573 aa)
	LRP5L	LDL receptor related protein 5 like. (252 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	MMP2	Matrix metallopeptidase 2. (664 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1555 aa)
	SRC	Tyrosine-protein kinase. (458 aa)
	GDF7	TGF_BETA_2 domain-containing protein. (361 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (744 aa)
	BSX	Brain specific homeobox. (233 aa)
	KDM5B	Lysine demethylase 5B. (1580 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
	CCL11	C-C motif chemokine. (97 aa)
	DUOX2	Dual oxidase 2. (1498 aa)
	PTCH1	Patched 1. (1446 aa)
	AREG	EGF-like domain-containing protein. (274 aa)
	RXFP1	Relaxin family peptide receptor 1. (779 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (549 aa)
	GLI3	GLI family zinc finger 3. (1580 aa)
	TGFA	Transforming growth factor alpha. (181 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (751 aa)
	HOXA13	Homeobox domain-containing protein. (209 aa)
	PLXNA1	Plexin A1. (1915 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa)
	PLAG1	PLAG1 zinc finger. (500 aa)
	PAX6	Uncharacterized protein. (467 aa)
	CSMD2	CUB and Sushi multiple domains 2. (3591 aa)
	EGFR	Receptor protein-tyrosine kinase. (1201 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	BCL2	ENSPPAP00000031741	ENSPPAP00000017780	Androgen receptor.	BCL2 apoptosis regulator.	0.513
AR	EGFR	ENSPPAP00000031741	ENSPPAP00000043172	Androgen receptor.	Receptor protein-tyrosine kinase.	0.702
AR	ESR1	ENSPPAP00000031741	ENSPPAP00000006837	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.834
AR	HOXB13	ENSPPAP00000031741	ENSPPAP00000009139	Androgen receptor.	Homeobox B13.	0.676
AR	IL6	ENSPPAP00000031741	ENSPPAP00000025189	Androgen receptor.	Uncharacterized protein.	0.458
AR	KDM5B	ENSPPAP00000031741	ENSPPAP00000037489	Androgen receptor.	Lysine demethylase 5B.	0.590
AR	MED1	ENSPPAP00000031741	ENSPPAP00000035122	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.657
AR	NKX3-1	ENSPPAP00000031741	ENSPPAP00000008388	Androgen receptor.	NK3 homeobox 1.	0.732
AR	NR3C1	ENSPPAP00000031741	ENSPPAP00000032671	Androgen receptor.	Nuclear receptor subfamily 3 group C member 1.	0.715
AR	PGR	ENSPPAP00000031741	ENSPPAP00000009925	Androgen receptor.	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.	0.716
AR	PHB2	ENSPPAP00000031741	ENSPPAP00000028255	Androgen receptor.	Prohibitin.	0.537
AR	SRC	ENSPPAP00000031741	ENSPPAP00000035810	Androgen receptor.	Tyrosine-protein kinase.	0.915
AREG	CCL11	ENSPPAP00000039357	ENSPPAP00000038423	EGF-like domain-containing protein.	C-C motif chemokine.	0.430
AREG	CSF1R	ENSPPAP00000039357	ENSPPAP00000038014	EGF-like domain-containing protein.	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.673
AREG	EGFR	ENSPPAP00000039357	ENSPPAP00000043172	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.997
AREG	EPHA2	ENSPPAP00000039357	ENSPPAP00000002235	EGF-like domain-containing protein.	EPH receptor A2.	0.701
AREG	ESR1	ENSPPAP00000039357	ENSPPAP00000006837	EGF-like domain-containing protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.509
AREG	FGF7	ENSPPAP00000039357	ENSPPAP00000028155	EGF-like domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.525
AREG	FGF8	ENSPPAP00000039357	ENSPPAP00000034277	EGF-like domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.442
AREG	FGFR2	ENSPPAP00000039357	ENSPPAP00000023314	EGF-like domain-containing protein.	Fibroblast growth factor receptor.	0.775